Search results for "CAI"
showing 10 items of 579 documents
Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine.
2008
The persistent nature of addiction has been associated with activity-induced plasticity of neurons within the striatum and nucleus accumbens (NAc). To identify the molecular processes leading to these adaptations, we performed Cre/loxP-mediated genetic ablations of two key regulators of gene expression in response to activity, the Ca 2+ /calmodulin-dependent protein kinase IV (CaMKIV) and its postulated main target, the cAMP-responsive element binding protein (CREB). We found that acute cocaine-induced gene expression in the striatum was largely unaffected by the loss of CaMKIV. On the behavioral level, mice lacking CaMKIV in dopaminoceptive neurons displayed increased sensitivity to cocai…
Alternative treatments of breakthrough pain in patients receiving spinal analgesics for cancer pain.
2005
Patients who experience a poor response to different systemic opioid trials (oral and intravenous) are candidates for spinal treatment. Breakthrough pain occurring in this group of patients is challenging for physicians. This phenomenon has never been described in this context and the treatment is quite difficult, as patients already demonstrated a poor response to systemic opioids. We report a preliminary experience of alternative methods, including the intrathecal injection of local anesthetic boluses as needed, or alternatively, the use of sublingual ketamine. Twelve consecutive patients with advanced cancer and pain were selected for intrathecal treatment after receiving different trial…
Cocaine or phenylephrine/lignocaine for nasal fibreoptic intubation?
1996
In order to assess if a mixture of phenylephrine/lignocaine is as effective as cocaine for local analgesia and vasoconstriction during nasal fibreoptic intubation, 99 patients receiving topical nasal analgesia either with cocaine 10% or a mixture of phenylephrine 1% and lignocaine 4% were studied in a randomized double-blind investigation. After topical analgesia a flexible fibreoptic endoscope was advanced through a nostril. Larynx, glottis and trachea were endoscopically sprayed with lignocaine. Following induction of anaesthesia a nasotracheal tube was inserted fibreoptically. Pain intensity and amount of epistaxis during endoscopy were assessed. Blood pressure, heart rate and ECG-ST seg…
Aspetti tipo-cronologici e archeometrici delle ceramiche africane nel territorio di Cignana (Naro, AG, Sicilia)
2020
Il progetto di ricerca, condotto in cotutela tra l'Università di Palermo e Aix-Marseille Université, si basa sullo studio delle ceramiche africane importate in Sicilia tra la fine del I e il VII secolo d.C.. La ricerca si basa sui frammenti - tutte le classi incluse - raccolti dal gruppo di ricerca di Palermo durante le ricognizioni archeologiche nei dintorni della villa romana di Cignana (Agrigento) e nell'entroterra di Termini Imerese (Palermo). L'approccio multidisciplinare archeologico ed archeometrico, condotto in collaborazione con diversi specialisti di queste discipline, ha permesso di definire l'origine delle diverse produzioni e di riflettere sulla loro circolazione in Sicilia, in…
A Chain of Voices: A "Masters and Slaves" Narrative
2022
Because no less than thirty different narrators take turns to tell us the story of a slave revolt, A Chain of Voices can be read as Brink's attempt at revisiting the classical "slave narrative", turning it into a polyphonic "masters and slaves" narrative in which everyone is given a say. This article examines how this polyphonic, and even multifocal, mode of narration enables Brink to write back to both classical slave narratives and to their twentieth-century counterparts, the neo-slave narratives. What it suggests is that although A Chain of Voices bears many resemblances to neo-slave narratives in terms of form, especially because of its recourse to polyphony, it is also extremely close …
Effects of Cannabinoid Exposure during Adolescence on the Conditioned Rewarding Effects of WIN 55212-2 and Cocaine in Mice: Influence of the Novelty-…
2016
Adolescent exposure to cannabinoids enhances the behavioural effects of cocaine, and high novelty-seeking trait predicts greater sensitivity to the conditioned place preference (CPP) induced by this drug. Our aim was to evaluate the influence of novelty-seeking on the effects of adolescent cannabinoid exposure. Adolescent male mice were classified as high or low novelty seekers (HNS and LNS) in the hole-board test. First, we evaluated the CPP induced by the cannabinoid agonist WIN 55212-2 (0.05 and 0.075 mg/kg, i.p.) in HNS and LNS mice. Then, HNS and LNS mice were pretreated i.p. with vehicle, WIN 55212-2 (0.1 mg/kg), or cannabinoid antagonist rimonabant (1 mg/kg) and were subsequently con…
Approche culturelle en didactique des langues : hommage à Albane Cain
2012
International audience
El modulador alostérico negativo de los mGluR5, MPEP, potencia la reinstauración de la preferencia condicionada inducida con priming de cocaína
2019
Cocaine addiction is a chronic disorder with high relapse rates; therefore, understanding the neuronal mechanisms underlying drug-seeking during relapse is a priority to develop targeted pharmacotherapy. The metabotropic glutamate receptor 5 (mGluR5) seems to be involved in the reinstatement induced by cocaine-associated cues. The main objective of the study was to evaluate the efficacy of MPEP, a negative allosteric modulator of mGluR5, in attenuating or potentiating the reinstatement induced by priming doses of cocaine in the CPP paradigm, ultimately to further knowledge regarding the role of the mGluR5 in relapse into cocaine abuse. OF1 mice (48 female and 48 male) were conditioned in th…
Towards an automatic lab-on-valve-ion mobility spectrometric system for detection of cocaine abuse.
2017
A lab-on-valve miniaturized system integrating on-line disposable micro-solid phase extraction has been interfaced with ion mobility spectrometry for the accurate and sensitive determination of cocaine and ecgonine methyl ester in oral fluids. The method is based on the automatic loading of 500μL of oral fluid along with the retention of target analytes and matrix clean-up by mixed-mode cationic/reversed-phase solid phase beads, followed by elution with 100μL of 2-propanol containing (3% v/v) ammonia, which are online injected into the IMS. The sorptive particles are automatically discarded after every individual assay inasmuch as the sorptive capacity of the sorbent material is proven to b…
La lingua “inventata” di Andrea Camilleri: il peso della parola dialettale
2019
la singolare lingua delle opere di Andrea Camillerii spinge a considerare – semmai ce ne fosse bisogno – che la scrittura letteraria è fatta di parole e qualche appunto sulle parole può certo aiutare a cogliere i meccanismi del plurilinguismo letterario e, nel caso di Camilleri, le ragioni di un grandissimo successo editoriale e di una straordinaria popolarità. Le opere di Andrea Camilleri mostrano una certa (ma non spropositata) quantità di lessico “prettamente dialettale” (pari a circa il 20% delle parole che non coincidono con quelle dell’italiano letterario). Ma mentre una parte di questo lessico autoctono (costituito da voci di bassa frequenza all'interno di ciascuna opera e nell'inter…