Search results for "CALL"
showing 10 items of 2320 documents
Promoting Physical Activity Habits after Completing Secondary School: Does the Age Matter?
2022
Physical inactivity is one of the most important problems in our society, especially during adolescence. During this stage of schooling, students practice physical activity in physical education classes, but after they finish school, many of them stop practicing it. This research aims to determine which variables predict the intention to practice physical activity after finishing secondary school and to discover the effect that age during adolescence has on these predictive variables. A questionnaire was administered to a sample of secondary school students. The results show that physical exercise identity influences the three antecedents of this theory, while the attitude towards the behav…
Physiologically based metformin pharmacokinetics model of mice and scale-up to humans for the estimation of concentrations in various tissues
2020
Metformin is the primary drug for type 2 diabetes treatment and a promising candidate for other disease treatment. It has significant deviations between individuals in therapy efficiency and pharmacokinetics, leading to the administration of an unnecessary overdose or an insufficient dose. There is a lack of data regarding the concentration-time profiles in various human tissues that limits the understanding of pharmacokinetics and hinders the development of precision therapies for individual patients. The physiologically based pharmacokinetic (PBPK) model developed in this study is based on humans’ known physiological parameters (blood flow, tissue volume, and others). The missing tissue-s…
The bilateral field advantage effect in memory precision.
2018
Previous research has demonstrated that visual working memory performance is better when visual items are allocated in both left and right visual fields than within only one hemifield. This phenomenon is called the bilateral field advantage (BFA). The BFA is thought to be driven by an enhanced probability of storage, rather than by greater precision. In the present experiments, we sought to test whether the BFA can also extend to precision when the parameters of the task are modified. Using a moderate number of to-be-remembered items and 400 ms presentation time, we found better precision in the bilateral condition than in the unilateral condition. The classic BFA was still found in the for…
Cost of reproduction in Callosobruchus maculatus: effects of mating on male longevity and the effect of male mating status on female longevity.
2005
One of the most studied life-history trade-offs is that resulting from the cost of reproduction: a trade-off arises when reproduction diverts limited resources from other life-history traits. We examine the cost of reproduction in male, and the effect of male mating status on female Callosobruchus maculatus seed beetles. Cost of reproduction for male C. maculatus was manifested as reduced longevity. There was also a positive relationship between male body size and male longevity. Females mated to males that had already copulated twice did not live as long as females mated to males that had copulated once or not at all. The third copulation of males also lasted longer than the two previous o…
High blood pressure responders show largest increase in heartbeat perception accuracy after post-learning stress following a cardiac interoceptive le…
2020
Mental disorders with physical symptoms, e.g. somatic symptom disorder, are characterized by altered interoceptive accuracy (IAc), which can be explained by individual differences in interoceptive learning (IL). We investigated if stress facilitates IL. Seventy-three healthy participants performed a heartbeat counting task (HCT: T1) and a heartbeat perception training (HBPT). After exposure to a socially-evaluated cold pressor stress test (SECPT; n = 48) or a control condition (n = 25), two more HCTs were performed (T2: 30 min after SECPT; T3: 24 h later). After the HBPT, all participants showed an increase in IAc. We separated the stress group into high vs. low systolic blood pressures (SB…
In toxic demyelination oligodendroglial cell death occurs early and is FAS independent
2010
Oligodendroglial cell death is a frequent phenomenon of many neurological diseases, e.g. in demyelinating diseases such as multiple sclerosis (MS). The underlying mechanisms are largely unknown. Here, we demonstrate that in the toxic demyelination cuprizone model, oligodendroglial cell death and downregulation of myelin genes start days after initiation of the cuprizone diet and weeks before demyelination is obvious. In early – but not in later – stages, dying oligodendrocytes express activated caspase 3, suggesting a switch from classical apoptotic pathways to caspase 3-independent mechanisms during the course of the cuprizone diet. The expression level of FAS in the corpus callosum, a cel…
Psychometric properties of the Somatic Symptom Scale 8 (SSS-8) in a representative sample of German adolescents.
2021
Abstract Objective The psychometric properties of the Somatic Symptom Scale 8 (SSS-8) have been investigated in different studies. However, there is no study examining its psychometric properties on representative data of adolescents. The study at hand will present results from a large representative sample of German adolescents (13 to 18 years). Methods The following analyses draw on cross-sectional data from German ninth-grade students collected in 2015. Altogether, 10,638 individuals were surveyed with a return rate of 68.5% as part of a periodic representative survey in the German federal state of Lower Saxony. Results For the SSS-8, coefficient omega for the full sample was ω = 0.90, a…
Do mental processes share a domain-general resource?
2010
What determines success and failure in dual-task situations? Many theories propose that the extent to which two activities can be performed concurrently depends on the nature of the information involved in the activities. In particular, verbal and visuospatial activities are thought to be fueled by distinct resources, so that interference occurs between two verbal activities or two visuospatial activities, but little or no interference occurs between verbal and visuospatial activities. The current study examined trade-offs in four dual-task situations in which participants maintained verbal or visuospatial information while concurrently processing either verbal or visuospatial information.…
The Drosophila ACP65A cuticle gene: deletion scanning analysis of cis-regulatory sequences and regulation by DHR38.
2005
The regulatory sequences of the Drosophila ACP65A cuticle gene were analyzed in vivo in transgenic flies, using both fusion genes constructs and transposase-mediated deletions within a P element containing ACP65A regulatory sequences fused to the lacZ gene (deletion scanning). The sequences located between −594 and +161 are sufficient to confer both temporal and spatial expression specificities, indicating the presence of tissue-specific enhancers and response elements to hormone-induced factors. In addition, timing of expression and tissue-specificity appear to be controlled by distinct cis-regulatory elements, which suggests the existence of independent hormonal and tissue-specific signal…
XRCC5 as a Risk Gene for Alcohol Dependence : Evidence from a Genome-Wide Gene-Set-Based Analysis and Follow-up Studies in Drosophila and Humans
2015
Genetic factors play as large a role as environmental factors in the etiology of alcohol dependence. Although genome-wide association studies (GWAS) enable systematic searches for loci not hitherto implicated in the etiology of alcohol dependence, many true findings may be missed due to correction for multiple testing. The aim of the present study was to circumvent this limitation by searching for biological system-level differences, and then following up these findings in humans and animals. Gene-set based analysis of GWAS data from 1333 cases and 2168 controls identified 19 significantly associated gene-sets of which five could be replicated in an independent sample. Clustered in these ge…