Search results for "CAP"
showing 10 items of 8832 documents
Cefalea postpunción dural: correlación clínico-radiológica.
2015
El síndrome de hipotensión intracraneal ha sido ampliamente estudiado por parte de los profesionales de Neurología, de lo que se derivan gran cantidad de publicaciones en las que se describen sus manifestaciones clínicas, radiológicas y anatomopatológicas, así como diferentes teorías para explicar su fisiopatología. Por otro lado, se considera a la cefalea postpunción dural (CPPD) como síntoma del síndrome de hipotensión intracraneal de causa conocida, no habiendo sido estudiado como patología independiente del resto de las causas. La falta de estudios de una complicación de una técnica habitual en Anestesiología, como es la punción dural, con un diagnóstico casi exclusivamente clínico y qu…
ASPERGILOSIS PULMONAR INVASIVA EN PACIENTES CON SINDROME DE DISTRÉS RESPIRATORIO POR COVID-19
2021
Resumen Los pacientes con COVID-19 que ingresan en una unidad de cuidados intensivos (UCI), tienen un alto riesgo de desarrollar infecciones secundarias, incluyendo infecciones fungicas invasivas como aspergilosis pulmonar invasiva (API). El objetivo principal fue el analisis de los casos con sospecha de COVID-19 Associated Pulmonary Aspergillosis (CAPA) en nuestra unidad. En estos pacientes realizamos cultivo micologico en el lavado broncoalveolar como metodos de aislamiento de Aspergillus sp. Se siguio el algoritmo AspICU para establecer el diagnostico de API probable. Ademas, considerando tambien relevante la positividad del antigeno de galactomanano. Se confirmo API probable en 3 de ell…
Pathophysiology of respiratory failure
2013
Summary Respiratory failure (RF) is defined as a disturbance in gas exchange in the respiratory system which produces in arterial BGA a PaO 2 2 > 50 mmHg (hypercapnia). However hypoxaemic normocapnic (or hypocapnic) RF due to the failure in gas exchange is very common and should be separated from mechanical RF. Respiratory failure (hypercapnic) with or without hypoxaemia related to a failure in the respiratory pump. This review is focused on the pathophysiology of the mechanical RF less well known amongst anaesthesiologists.
The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development
2014
Low density lipoprotein receptor-related protein 1 (LRP1) is indispensable for embryonic development. Comparing different genetically engineered mouse models, we found that expression of Lrp1 is essential in the embryo proper. Loss of LRP1 leads to lethal vascular defects with lack of proper investment with mural cells of both large and small vessels. We further demonstrate that LRP1 modulates Gi-dependent sphingosine-1-phosphate (S1P) signaling and integrates S1P and PDGF-BB signaling pathways, which are both crucial for mural cell recruitment, via its intracellular domain. Loss of LRP1 leads to a lack of S1P-dependent inhibition of RAC1 and loss of constraint of PDGF-BB-induced cell migra…
X-ray measurements of charge transfer reactions involving cold, very highly charged ions
1999
The magnetic trapping mode of the Livermore high-energy Electron Beam Ion Trap is exploited to study charge transfer reactions between cold (few eV/amu) highly charged ions and gases. By selectively puffing neutral gases and monitoring the x-ray emission, state-selective measurements of the charge transfer reaction channels are possible. The observed K-shell x-ray spectra show prominent emission from high-n levels decaying to the n = 1 ground level, which is enabled by electron capture into states with low orbital angular momentum. A comparison with modeling calculations, therefore, allows a determination of the range of principal and angular momentum quantum numbers involved in the reactio…
Surface charge fine tuning of reversed-phase/weak anion-exchange type mixed-mode stationary phases for milder elution conditions.
2015
A series of new mixed-mode reversed-phase/weak anion-exchange (RP/WAX) phases have been synthesized by immobilization of N-undecenyl-3-α-aminotropane onto thiol-modified silica gel by thiol-ene click chemistry and subsequent introduction of acidic thiol-endcapping functionalities of different type and surface densities. Click chemistry allowed to adjust a controlled surface concentration of the RP/WAX ligand in such a way that a sufficient quantity of residual thiols remained unmodified which have been capped by thiol click with either 3-butenoic acid or allylsulfonic acid as co-ligands. In another embodiment, performic acid oxidation of N-undecenyl-3-α-aminotropane-derivatized thiol-modifi…
Characterization of poly(4-vinylpyridine 1-oxide) by free-solution capillary electrophoresis and micellar electrokinetic chromatography
2008
The migration characteristics of poly(4-vinylpyridine 1-oxide) (PVP-NO) in phosphate buffers of acidic pH (20 mM H 3 PO 4 or NaH 2 PO 4 ) have been studied using both free-solution capillary electrophoresis (FSCE) and MEKC. To inhibit adsorption, 250 mM o-phosphoethanolamine (2-aminoethyl dihydrogen phosphate) was used. In FSCE, PVP-NO showed a narrow peak and a broader band, both having anionic behavior. These peak and band were attributed to the free and aggregated or micellized PVP-NO forms, respectively. According to surface tension measurements, the CMC of SDS in the BGE was 1.8 and 0.48 mM in the absence and in the presence of 1000 μpg/mL PVP-NO, respectively, and the association of t…
Characterization and determination of poly(vinylpyrrolidone) by complexation with an anionic azo-dye and nonequilibrium capillary electrophoresis
2009
Using capillary zone electrophoresis in nonequilibrium conditions, the complexes of poly(vinylpyrrolidone) (PVP) with anionic azo-dyes dissociate following a first-order kinetics. Two peaks due to the remaining PVP-dye complexes and the equilibrium concentration of the free dye, plus an exponential region due to the dye liberated by the complexes during the electrophoretic run, are obtained. This behaviour was closely similar to that described in the literature for protein-probe and DNA-protein mixtures, upon application of the technique known as nonequilibrium capillary electrophoresis of equilibrium mixtures or NECEEM. Using Congo Red and Acid Blue 113, information about the maximal stoic…
Stable-bond polymeric reversed-phase/weak anion-exchange mixed-mode stationary phases obtained by simultaneous functionalization and crosslinking of …
2019
Abstract A polymeric reversed-phase/weak anion exchange (Poly-RP/WAX) mixed-mode stationary phase has been prepared by coating of a poly(3-mercaptopropyl)methylsiloxane film on vinyl-modified silica (100 A, 5 μm) and simultaneous in situ functionalization with N-(10-undecenoyl)-3-aminoquinuclidine as well as crosslinking to the vinyl silica surface by solventless thiol-ene double click reaction. Such bonding chemistry showed greatly enhanced stability compared to brush-type analogs with bifunctional siloxane bonding to silica. Solid-state 29Si-CP/MAS NMR confirmed the immobilization of the siloxane layer. pH-Dependent ζ-potential determinations revealed a high anion-exchange capacity over t…
Surface-anchored counterions on weak chiral anion-exchangers accelerate separations and improve their compatibility for mass-spectrometry-hyphenation
2017
In the present work we propose new variants of chiral stationary phases (CSP) with tert-butylcarbamoylquinine (tBuCQN) as chiral selector molecule. Four tBuCQN-CSPs with distinct bonding chemistries are compared in terms of their pH-dependent surface charge by ζ-potential determinations, by achiral and chiral liquid chromatographic tests and LC-ESI-MS hyphenation. In one embodiment tBuCQN was immobilized on 3-mercaptopropylmethylsilyl-modified silica by thiol-ene click reaction (brush type CSP with selector coverage of 0.38mmol/g). In another embodiment, poly-(3-mercaptopropyl)-methylsiloxane was coated onto vinylized silica particles in presence of tBuCQN and radical initiator. The tBuCQN …