Search results for "CASS"

Mikroservisu izstrāde izklaides platformai aizmugurējā sistēmā

2019

Kvalifikācijas darbā tika veikta izklaides platformas “Shortcut.lv” mikroservisu izstrāde aizmugurējā sistēmā. Tas sastāv no programmatūras prasību speficikācijas, programmatūras projektējuma un testēšanas dokumentācijas. Darba mērķis ir izveidot vairāku mikroservisu funkcionalitāti, kas ir jaunās aizmugurējās sistēmas sastāvdaļa. Mikroservisu izveidē tika izmantota PHP programmēšanas valoda, Lumen ietvars, Apache Cassandra datu bāzu tehnoloģija. Testiem tika izmantots Codeception automatizētās testēšanas ietvars.

Low-pressure ferroelastic phase transition in rutile-type AX2 minerals: cassiterite (SnO2), pyrolusite (MnO2) and sellaite (MgF2)

2019

The structural behaviour of cassiterite (SnO2), pyrolusite (MnO2) and sellaite (MgF2), i.e. AX2-minerals, has been investigated at room temperature by in situ high-pressure single-crystal diffraction, up to 14 GPa, using a diamond anvil cell. Such minerals undergo a ferroelastic phase transition, from rutile-like structure (SG: P42/mnm) to CaCl2-like structure (SG: Pnnm), at ≈ 10.25, 4.05 and 4.80 GPa, respectively. The structural evolution under pressure has been described by the trends of some structure parameters that are other than zero in the region of the low-symmetry phase’s stability. In particular, three tilting-angles (ω, ω′, ABS) and the metric distortion of the cation-centred oc…

Induction of Human P-Glycoprotein in Caco-2 cells: Development of a Highly Sensitive Assay System for P-Glycoprotein-Mediated Drug Transport

2006

The aim of this work is to develop a highly sensitive assay system for P-gp-mediated transport by using two methods, induction of P-gp and short-term culture of Caco-2 cells. To induce P-gp in Caco-2 cells, cells were cultured in vinblastine-containing medium. The mRNA level of P-gp was approximately 7-fold higher in Caco-2 cells cultured with vinblastine (P-gp-induced Caco-2 cells) than in control cells. Western blot analysis showed a significant increase in P-gp expression. After cell differentiation, the mRNA level of P-gp was downregulated, however, P-gp-induced Caco-2 cells still possessed a 5.6-fold higher mRNA level of P-gp compared to control cells. Polarized transport of substrate …

Pharmacogenomic and molecular docking studies on the cytotoxicity of the natural steroid wortmannin against multidrug-resistant tumor cells

2014

Wortmannin is a cytotoxic compound derived from the endophytic fungi Fusarium oxysporum, Penicillium wortmannii and Penicillium funiculosum that occurs in many plants, including medicinal herbs. The rationale to develop novel anticancer drugs is the frequent development of tumor resistance to the existing antineoplasic agents. Therefore, it is mandatory to analyze resistance mechanisms of novel drug candidates such as wortmannin as well to bring effective drugs into the clinic that have the potential to bypass or overcome resistance to established drugs and to substantially increase life span of cancer patients. In the present project, we found that P-glycoprotein-overexpressing tumor cells…

Relevance of Multidrug Resistance Proteins on the Clinical Efficacy of Cancer Therapy

2005

Variations in drug uptake and efflux, as well as changes in intracellular drug entrapment and distribution may represent important resistance mechanisms to cancer therapy. A variety of ATP binding cassette transporters (ABC) localised in multiple cell membranes is implied in those phenomena, representing a mechanism of protection of cells against xenobiotics. Many cancer cell lines over express some ABC transporters, especially p-glycoprotein, MRP1 and BCRP. This over expression is related to worse cancer treatment outcome and, in some cases, reduced overall survival of cancer patients. This paper reviews the location and physiological role of the three transporters mentioned and also descr…

Intracellular retention of ABL kinase inhibitors determines commitment to apoptosis in CML cells

2012

PLoS one 7(7), e40853 (2012). doi:10.1371/journal.pone.0040853

Enterokoku antibakteriālās rezistences un VAN gēnu noteikšana

2019

Aktualitāte: Pēdējo gadu laikā pasaulē strauji pieaug enterokoku rezistence pret antibakteriālajiem līdzekļiem. Tas rada nopietnas problēmas pacientu ārstēšanā. Ierosinātāji ir grampozitīvas baktērijas. Infekciju ierosinātāji visbiežāk ir grampozitīvas baktērijas, tajā skaitā arī enterokoki. Tāpēc, autores Maģistra darba mērķis bija: noteikt no klīniskā materiāla izolēto enterokoku antibakteriālo jutību, kā arī noteikt vankomicīna rezistences (van) gēnus. Darba uzdevumi bija: Noteikt antibakteriālo jutību Enterococcus sp. celmiem, izmantojot Kirby-Bauer disku difūzijas metodi, bet vankomicīna rezistences gēni enterokokos tika identificēti izmantojot Genotype Enterococcus testu. Laikā no 01.…

Le non-respect de l’ordre du jour établi à la convocation de l’Assemblée Générale: un motif légitime à l’annulation d’une décision sociale sur la bas…

2023

L’exclusion abusive d’un associé par une assemblée générale extraordinaire convoquée pour prendre acte de sa démission, conduit à l’annulation de la décision de cette assemblée sur le fondement de l’article 1844-10 al. 3 du code civil.

Humanities and Social Sciences. Latvia: Vol. 27, N 1 (Spring-Summer 2019)

2019

El Picasso coruñés como inicio inexcusable y referencia de su proyecto revolucionario (1891-1895)

2013

Análisis de uno de los períodos más desconocidos de Pablo Picasso, el que vivió en A Coruña cuatro años (1891-1895), siendo todavía adolescente y que los expertos consideran clave en el desarrollo de su proyecto. Allí dio inicio a su lenguaje versátil y a un inventario de géneros e iconografías que persistirían como identidad hasta el final de su vida. Sería muy difícil entender al verdadero Picasso pasando por alto este período juvenil, al que los biógrafos generalistas apenas han hecho caso, al contrario de los más rigurosos especialistas, que lo consideran fundamental. Research into one of the least known periods of Pablo Picasso. He lived for four years in A Coruña when he was a teenage…