Search results for "CASS"

showing 10 items of 433 documents

Multiple Pluripotent Stem Cell Markers in Human Anaplastic Thyroid Cancer: The Putative Upstream Role of SOX2

2013

Anaplastic thyroid carcinoma (ATC) is a rare and aggressive endocrine tumor with highly undifferentiated morphology. It has been suggested that cancer stem cells (CSCs) might play a central role in ATC. The objectives of this study were (i) to characterize CSCs from ex vivo ATC specimens by investigating the expression of several pluripotent stem cell markers, and (ii) to evaluate in vitro drug resistance modifications after specific CSC transcription factor switch-off.In ex vivo experiments, eight formalin-fixed, paraffin-embedded ATC specimens were analyzed by reverse-transcription and real-time quantitative PCR and immunohistochemistry. In in vitro experiments using ATC SW1736 cells, the…

Pluripotent Stem Cellscongenital hereditary and neonatal diseases and abnormalitiesEndocrinology Diabetes and MetabolismDown-RegulationBiologyThyroid Carcinoma AnaplasticAnaplastic thyroid cancer cancer stem cell SOX-2Settore MED/13 - EndocrinologiaThyroid carcinomaKruppel-Like Factor 4EndocrinologySOX2Cancer stem cellCell Line TumormedicineATP Binding Cassette Transporter Subfamily G Member 2HumansNeoplasmThyroid NeoplasmsAnaplastic thyroid cancerInduced pluripotent stem cellHomeodomain ProteinsSOXB1 Transcription FactorsNanog Homeobox ProteinNanog Homeobox ProteinThyroid Cancer and Nodulesmedicine.diseaseNeoplasm ProteinsUp-RegulationDoxorubicinDrug Resistance NeoplasmCell cultureNeoplastic Stem CellsCancer researchATP-Binding Cassette TransportersCisplatinOctamer Transcription Factor-3Thyroid
researchProduct

COMPORTAMENTO DI IMPALCATI DA PONTE A CASSONE IN ACCIAIO-CALCESTRUZZO CON ANIMA ONDULATA

2013

La memoria riguarda il comportamento di un impalcato di ponte stradale a cassone avente le anime sagomate secondo una sinusoide, con soletta in c.a. collaborante. L'impalcato presenta schema statico longitudinale di trave continua su 4 appoggi. The paper concerns the behaviour of a box-girder bridge deck road having a steel box and a concrete slab. The steel webs are shaped according to a sine wave. The deck has a width of 13.70 m and a length of 182 m, with the longitudinal static scheme as a continuous beam on four supports. The study highlights the reliability of this constructive solution.

Ponti a cassone Sistemi misti acciaio-calcestruzzo pareti in acciaio ondulateSettore ICAR/09 - Tecnica Delle Costruzioniwebs shaped as sine wavebox-girder steel bridge
researchProduct

Contrôle du juge de cassation sur la qualification juridique des faits de transfert d'un risque d'exploitation

2022

Pouvoirs du juge de cassation[SHS.DROIT] Humanities and Social Sciences/LawContratContentieuxContrôle de qualification juridiqueConcession de servicePouvoirs et devoirs du jugeProcédure administrative contentieuse
researchProduct

Structural verification and manufacturing procedures of the cooling system, for DEMO divertor target (OVT)

2019

The paper presents the design activities and testing plan of a vertical target mock-up, developed within the pre-conceptual design phase for DEMO Work Package DIV-1 “Divertor Cassette Design and Integration” - EUROfusion Power Plant Physics & Technology (PPPT) program. Activities concerning the Divertor Outboard Vertical Target cooling mock-up are presented in term of CAD model, thermal-hydraulic numerical simulation, structural analysis, structural integrity verification and manufacturing procedure. Moreover, the mechanical dimensions of support systems for Plasma Facing Components (PFCs), manifold and diffuser have been analyzed in detail, in order to avoid structural fault during the tes…

Power stationComputer simulationDesign activitiesDivertor target cooling mock-upNuclear engineeringDivertorMechanical EngineeringDivertor cassetteCADFault (power engineering)01 natural sciences010305 fluids & plasmasNuclear Energy and Engineering0103 physical sciencesWater coolingDEMO; Divertor cassette; Divertor target cooling mock-up; Civil and Structural Engineering; Nuclear Energy and Engineering; Materials Science (all); Mechanical EngineeringGeneral Materials ScienceMaterials Science (all)Test plan010306 general physicsDEMO; Divertor cassette; Divertor target cooling mock-upDEMOSettore ING-IND/19 - Impianti NucleariCivil and Structural Engineering
researchProduct

Il rigore delle Sezioni Unite nel caso di omessa notifica del ricorso introduttivo nelle controversie di lavoro

2009

Processo civile - notifica - Cassazione a Sezioni UniteSettore IUS/15 - Diritto Processuale Civile
researchProduct

Silymarin and Cancer: A Dual Strategy in Both in Chemoprevention and Chemosensitivity

2020

Silymarin extracted from milk thistle consisting of flavonolignan silybin has shown chemopreventive and chemosensitizing activity against various cancers. The present review summarizes the current knowledge on the potential targets of silymarin against various cancers. Silymarin may play on the system of xenobiotics, metabolizing enzymes (phase I and phase II) to protect normal cells against various toxic molecules or to protect against deleterious effects of chemotherapeutic agents on normal cells. Furthermore, silymarin and its main bioactive compounds inhibit organic anion transporters (OAT) and ATP-binding cassettes (ABC) transporters, thus contributing to counteracting potential chemor…

Programmed cell deathsilymarinCellChemosensitizerPharmaceutical SciencechemopreventiveATP-binding cassette transporterApoptosisReviewProtective AgentsChemopreventionsilybinAnalytical Chemistrylcsh:QD241-44103 medical and health sciences0302 clinical medicinelcsh:Organic chemistryDrug DiscoverymedicineHumansPhysical and Theoretical ChemistryReceptor030304 developmental biology0303 health sciencesChemistryOrganic ChemistryCancerCell Cycle CheckpointsCell cyclemedicine.diseasemedicine.anatomical_structureChemistry (miscellaneous)intrinsic and extrinsic pathwayDrug Resistance Neoplasm030220 oncology & carcinogenesisCancer cellchemosensitizerCancer researchMolecular Medicinemetabolizing enzymesATP-Binding Cassette Transporterscell cycleABC transporterSignal TransductionMolecules
researchProduct

Analysis of the MHC Class I Antigen Presentation Machinery in Human Embryonal Carcinomas: Evidence for Deficiencies in TAP, LMP and MHC Class I Expre…

1998

The expression of the major histocompatibility complex (MHC) class I antigens is suppressed in early post-implantation embryonic cells as well as in embryonal carcinoma (EC) cells, but could be upregulated by treatment with interferon (IFN)-gamma or retinoic acid. In a number of human and murine tumours, defects in the expression of the different components of the MHC class I antigen processing machinery, such as the proteasomal subunits LMP-2 and LMP-7 and the peptide transporters TAP-1 and TAP-2, account for impaired MHC class I surface expression. Here, we analysed the constitutive and IFN-gamma regulated mRNA and protein expression of the LMP, TAP and MHC class I molecules in the human …

Proteasome Endopeptidase ComplexCD74HIV AntigensImmunologyCD1CytomegalovirusInterferon-gammaATP Binding Cassette Transporter Subfamily B Member 3Multienzyme ComplexesCarcinoma EmbryonalMHC class ITumor Cells CulturedHumansATP Binding Cassette Transporter Subfamily B Member 2Antigens ViralAntigen PresentationbiologyAntigen processingMHC class I antigenHistocompatibility Antigens Class ITemperatureGeneral MedicineTransporter associated with antigen processingMHC restrictionMolecular biologyUp-RegulationCysteine EndopeptidasesProtein Biosynthesisbiology.proteinATP-Binding Cassette TransportersPeptidesCD8Scandinavian Journal of Immunology
researchProduct

Bipartite regulation of different components of the MHC class I antigen-processing machinery during dendritic cell maturation

2001

Dendritic cells (DC) are professional antigen-presenting cells (APC) which proceed from immature to a mature stage during their final differentiation. Immature DC are highly effective in terms of antigen uptake and processing, whereas mature DC become potent immunostimulatory cells. Until now, the expression profiles of the major components of the MHC class I antigen-processing machinery (APM) during DC development have not been well characterized. In this study, the mRNA and protein expression levels of the IFN-gamma inducible proteasome subunits, of the proteasome activators PA28, and of key components required for peptide transport and MHC class I-peptide complex assembly have been evalu…

Proteasome Endopeptidase ComplexCD74ImmunologyAntigen presentationLipopolysaccharide ReceptorsDown-RegulationImmunoglobulinsMuscle ProteinsAntiportersMonocytesMultienzyme ComplexesMHC class IHumansImmunology and AllergyATP Binding Cassette Transporter Subfamily B Member 2Antigen PresentationMHC class IIbiologyAntigen processingMHC class I antigenHistocompatibility Antigens Class IMembrane Transport ProteinsProteinsCell DifferentiationDendritic CellsGeneral MedicineTransporter associated with antigen processingMHC restrictionMolecular biologyUp-RegulationCell biologyCysteine EndopeptidasesProtein TransportProtein Biosynthesisbiology.proteinATP-Binding Cassette TransportersPeptidesInternational Immunology
researchProduct

Functional deficiencies of components of the MHC class I antigen pathway in human tumors of epithelial origin

2000

An association between oncogenic transformation and repression of different components of the MHC class I antigen processing machinery (APM) have been described in murine model systems. In order to discover whether a similar correlation exists, human tumor cell lines of distinct histology with altered ras protein were analyzed for the expression of APM components utilizing RT-PCR and Western blot analyses. A heterogeneous expression pattern of MHC class I antigens, TAP peptide transporter, proteasome subunits, proteasome activator PA28 and the chaperones calnexin, calreticulin as well as tapasin was displayed by these tumor cell lines. Single or combined deficiencies in the expression and/o…

Proteasome Endopeptidase ComplexGene ExpressionInterferon-gammaMiceTapasinATP Binding Cassette Transporter Subfamily B Member 3Multienzyme ComplexesCalnexinGene expressionMHC class ITumor Cells CulturedAnimalsHumansNeoplasms Glandular and EpithelialATP Binding Cassette Transporter Subfamily B Member 2DNA PrimersAntigen PresentationTransplantationBase SequencebiologyAntigen processingMHC class I antigenHistocompatibility Antigens Class IProteinsHematologyTransporter associated with antigen processingRecombinant ProteinsCell biologyCysteine EndopeptidasesGenes rasMutationCancer researchbiology.proteinATP-Binding Cassette TransportersCalreticulinBone Marrow Transplantation
researchProduct

Characterizing the N-terminal processing motif of MHC class I ligands.

2008

Abstract Most peptide ligands presented by MHC class I molecules are the product of an intracellular pathway comprising protein breakdown in the cytosol, transport into the endoplasmic reticulum, and successive N-terminal trimming events. The efficiency of each of these processes depends on the amino acid sequence of the presented ligand and its precursors. Thus, relating the amino acid composition N-terminal of presented ligands to the sequence specificity of processes in the pathway gives insight into the usage of ligand precursors in vivo. Examining the amino acid composition upstream the true N terminus of MHC class I ligands, we demonstrate the existence of a distinct N-terminal proces…

Proteasome Endopeptidase ComplexImmunologyAmino Acid MotifsEndoplasmic ReticulumLigandsAminopeptidaseAminopeptidasesCell LineMiceCytosolCell Line TumorMHC class IImmunology and AllergyAnimalsHumansAmino Acid SequenceATP Binding Cassette Transporter Subfamily B Member 2Peptide sequenceAntigen PresentationbiologyLigandEndoplasmic reticulumHistocompatibility Antigens Class ITransporter associated with antigen processingPeptide FragmentsN-terminusBiochemistryProteasomebiology.proteinATP-Binding Cassette TransportersPeptidesHeLa CellsProtein BindingJournal of immunology (Baltimore, Md. : 1950)
researchProduct