Search results for "CCN"

Expression of WISPs and of their novel alternative variants in human hepatocellular carcinoma cells

2005

WISPs (Wnt-induced secreted proteins) are members of the CCN (CTGF/Cyr61/Nov) family involved in fibrotic disorders and tumorigenesis. They have a typical structure composed of four conserved cysteine-rich modular domains, but variants of CCN members lacking one or more modules, generated by alternative splicing or gene mutations, have been described in various pathological conditions. WISP genes were first described as downstream targets of the Wnt signaling pathway, which is frequently altered in human hepatocellular carcinoma (HCC). In the present study, WISP mRNA expression was analyzed by RT-PCR in four human HCC cell lines (HepG2, HuH-6, HuH-7, HA22T/VGH). Our results show for the fir…

Distrés emocional y problemas asociados en población oncológica adulta

2017

Objetivo: en este estudio se estima la prevalencia de distrés, se identifican los problemas asociados y se analiza el conocimiento y uso que hacen los pacientes sobre los recursos psicosociales disponibles en el centro hospitalario. Método: se lleva a cabo un estudio transversal en el que participan 203 pacientes oncológicos que están recibiendo tratamiento quimioterápico. En la evaluación se emplean el Inventario de Síntomas Breve-18 (BSI-18), el Listado de Problemas de NCCN y una encuesta sobre el conocimiento y uso de los recursos asistenciales del centro hospitalario. Resultados: la prevalencia de distrés en la muestra total es del 26%. Los problemas físicos son la principal fuente de d…

Acceso a la innovación farmacéutica en cáncer. Análisis sistemático

2022

Los precios de los fármacos oncológicos están creciendo de manera muy pronunciada y junto a un aumento considerable de la incidencia de esta patología, hacen que sea necesario abordar el tema de la asequibilidad, equidad y calidad del cuidado de la salud en cáncer si no queremos que los diferentes sistemas nacionales de salud entren en bancarrota. Se han generado muchas iniciativas cuyo objetivo es evaluar el beneficio clínico de las intervenciones y así, se financien aquellas intervenciones que aporten un mayor valor tanto para los pacientes oncológicos como para la sociedad en general. Esta tesis realiza un análisis de las diferentes herramientas e iniciativas puestas en marcha por los si…

Ordinamento professionale e mutamento di mansioni nel lavoro pubblico e privato: uno sguardo d'insieme

2021

Il saggio analizza la disciplina del mutamento di mansioni nel lavoro pubblico e privato, con particolare riferimento al rapporto tra lo ius variandi orizzontale e i sistemi di classificazione professionale di fonte contrattual-collettiva. La tesi è che la tecnica del rinvio all’autonomia collettiva, oggi delegata a definire l’area della mobilità orizzontale tanto nel settore pubblico quanto in quello privato, non esclude la sindacabilità delle scelte operate dalle parti sociali, a tutela dei valori costituzionali in cui si invera l’identità professionale del prestatore e contro il rischio di un’eccessiva dilatazione del debito negoziale.

TGF-β Signaling Pathways in Different Compartments of the Lower Airways of Patients With Stable COPD

2017

Background: The expression and localization of transforming growth factor-β (TGF-β) pathway proteins in different compartments of the lower airways of patients with stable COPD is unclear. We aimed to determine TGF-β pathway protein expression in patients with stable COPD. Methods: The expression and localization of TGF-β pathway components was measured in the bronchial mucosa and peripheral lungs of patients with stable COPD (n = 44), control smokers with normal lung function (n = 24), and control nonsmoking subjects (n = 11) using immunohistochemical analysis. Results: TGF-β1, TGF-β3, and connective tissue growth factor expression were significantly decreased in the bronchiolar epithelium…

Malattia e retribuzione di risultato nell'Area VI: dirigenti e professionisti dell'INPS

2012

2013

Abstract. As part of the CLACE-6 campaign we performed size-resolved CCN measurements for a~supersaturation range of S = 0.079 % to 0.66% at the high-alpine research station Jungfraujoch, Switzerland, in March~2007. The derived effective hygroscopicity parameter κ describing the influence of particle composition on CCN activity was on average 0.23–0.30 for Aitken (50–100 nm) and 0.32–0.43 for accumulation mode particles (100–200 nm). The campaign average value of κ = 0.3 is similar to the average value of κ for other continental locations. When air masses came from southeasterly directions crossing the Po Valley in Italy, particles were much more hygroscopic (κ ≈ 0.42) due to…

Size Matters More Than Chemistry for Cloud-Nucleating Ability of Aerosol Particles

2006

Size-resolved cloud condensation nuclei (CCN) spectra measured for various aerosol types at a non-urban site in Germany showed that CCN concentrations are mainly determined by the aerosol number size distribution. Distinct variations of CCN activation with particle chemical composition were observed but played a secondary role. When the temporal variation of chemical effects on CCN activation is neglected, variation in the size distribution alone explains 84 to 96% of the variation in CCN concentrations. Understanding that particles' ability to act as CCN is largely controlled by aerosol size rather than composition greatly facilitates the treatment of aerosol effects on cloud physics in re…

Concorsi pubblici e progressioni di carriera nella stagione del "grande reclutamento"

2022

il saggio affronta i principali problemi del sistema dei concorsi pubblici e della disciplina delle progressioni di carriera nel pubblico impiego privatizzato, alla luce delle innovazioni contenute nel d.l. 80/2021 e nella della sottoscrizione del nuovo CCNL per il comparto Funzioni Centrali.

Prognostic Relevance of CCN3 in Bone Sarcomas

2010

Osteosarcomas and Ewing’s sarcoma (EWS) are aggressive malignant bone tumors. In both cases, prognostic markers are lacking. Presently, only clinical features are widely accepted as prognostic indicators. In this study we assessed the prognostic value of CCN3 (Nov), a matricellular protein that belong to the CCN family of regulatory proteins, whose members were shown to play crucial roles in bone formation. In osteosarcomas, CCN3 expression levels represent a useful tool to early identification of patients with different prognosis. In both osteosarcomas and Ewing’s sarcomas, the expression of a full length CCN3 protein was associated to a worse prognostic and a higher risk to developing met…