Search results for "CEDU"

Shedding light on the elusive role of endothelial cells in cytomegalovirus dissemination.

2011

Cytomegalovirus (CMV) is frequently transmitted by solid organ transplantation and is associated with graft failure. By forming the boundary between circulation and organ parenchyma, endothelial cells (EC) are suited for bidirectional virus spread from and to the transplant. We applied Cre/loxP-mediated green-fluorescence-tagging of EC-derived murine CMV (MCMV) to quantify the role of infected EC in transplantation-associated CMV dissemination in the mouse model. Both EC- and non-EC-derived virus originating from infected Tie2-cre + heart and kidney transplants were readily transmitted to MCMV-naïve recipients by primary viremia. In contrast, when a Tie2-cre + transplant was infected by pri…

Polo-like kinase 1 as a target for human cytomegalovirus pp65 lower matrix protein

1999

ABSTRACT Human cytomegalovirus (HCMV) pp65 protein is the major constituent of viral dense bodies but is dispensable for viral growth in vitro. pp65 copurifies with a S/T kinase activity and has been implicated in phosphorylation of HCMV IE1 immediate-early protein and its escape from major histocompatibility complex 1 presentation. Furthermore, the presence of pp65 correlates with a virion-associated kinase activity. To clarify the role of pp65, yeast two-hybrid system (THS) screening was performed to identify pp65 cellular partners. A total of 18 out of 48 yeast clones harboring cDNAs for putative pp65 binding proteins encoded the Polo-like kinase 1 (Plk1) C-terminal domain. Plk1 behaved …

Estimation of flood inundation probabilities using global hazard indexes based on hydrodynamic variables

2008

In this paper a new procedure to derive flood hazard maps incorporating uncertainty concepts is presented. The layout of the procedure can be resumed as follows: (1) stochastic input of flood hydrograph modelled through a direct Monte-Carlo simulation based on flood recorded data. Generation of flood peaks and flow volumes has been obtained via copulas, which describe and model the correlation between these two variables independently of the marginal laws involved. The shape of hydrograph has been generated on the basis of a historical significant flood events, via cluster analysis; (2) modelling of flood propagation using a hyperbolic finite element model based on the DSV equations; (3) de…

Testing infiltration run effects on the estimated water transmission properties of a sandy-loam soil

2016

Abstract Testing factors influencing determination of soil water transmission properties by an infiltrometer method helps better interpretation of the collected data and allows the development of appropriate sampling strategies for the intended use of the data. These factors include the soil water content at the start of the experiment, the height from which water is poured onto the soil surface, and the duration of the infiltration run. A sandy-loam soil was sampled with the BEST (Beerkan Estimation of Soil Transfer parameters) procedure of soil hydraulic characterization and two heights of pouring of water (0.03 and 1.5 m) under three different initial soil water content, θ i (0.12 ≤ θ i …

Testing the BEST procedure to estimate the soil water retention curve

2012

The BEST (Beerkan Estimation of Soil Transfer parameters) procedure is attractive for simple soil hydraulic characterization but there is the need to test the reliability of the predictions. In this investigation, the BEST procedure to predict water retention of 199 Sicilian soils was evaluated. The BEST water retention model performed well (relative error, Er≤0.05) for approximately 80% of the soil samples. Low errors were obtained in soils with a high clay, cl, content (≥44%), whereas both high and low Er values were obtained in soils with a lower cl content. The BEST particle size distribution (PSD) model was accurate for 50% of the samples and the fitting accuracy increased with cl, wit…

Soil hydraulic properties determined by infiltration experiments and different heights of water pouring

2014

Abstract Establishing the dependence of the soil hydraulic characterization carried out by an infiltration experiment on the procedure used to apply water on the confined soil surface may help to better interpret the collected data and also to develop more accurate strategies for soil hydraulic characterization. Soil was sampled at four Sicilian sites with both the Simplified Falling Head (SFH) technique and the Beerkan Estimation of Soil Transfer parameters (BEST) procedure and two heights of water application (0.03 and 1.5 m). The most appropriate BEST algorithm to analyze the data was determined and the effect of the height of water pouring on the measured soil hydraulic properties was e…

Osteogenesis imperfecta and hyperplastic callus formation: light- and electron-microscopic findings.

1993

In rare cases of osteogenesis imperfecta, an "overshoot" growth of new bone may occur, which, clinically gives the impression of a tumour. This condition is known as hyperplastic callus formation. Morphology showed an excessive mixed desmal-chondral osteoneogenesis. Atypical collagen fibrils in non-callus tissue represent an indicator for this callus formation in individual patients.

Il diritto di difesa degli staff member nei sistemi di giustizia interna dell'Organizzazione Internazionale del Lavoro, dell'Organizzazione delle Naz…

IMAGE ANALYSIS FOR DETECTING THE TRANSVERSE PROFILE OF WORN-OUT RAILS

2012

Abstract — Over its useful life a railway track is subject to many mechanical and environmental stresses which gradually lead to its deterioration. Monitoring the wear condition of the railway superstructure is one of the key points to guarantee an adequate safety level of the railway transport system; in this field, the use of high-efficiency laser techniques has become consolidated and implemented in diagnostic trains (e.g. the “Archimede train” and the “Talete train” ) which allow to detect the track geometric parameters (gauge, alignment, longitudinal level, cross level, superelevation defect, etc.) and the state of rail wear (vertical, horizontal, 45-degree etc.) with very high accurac…

Fine Alignment of Thermographic Images for Robotic Inspection of Parts with Complex Geometries

2022

Increasing the efficiency of the quality control phase in industrial production lines through automation is a rapidly growing trend. In non-destructive testing, active thermography techniques are known for their suitability to allow rapid non-contact and full-field inspections. The robotic manipulation of the thermographic instrumentation enables the possibility of performing inspections of large components with complex geometries by collecting multiple thermographic images from optimal positions. The robotisation of the thermographic inspection is highly desirable to improve assessment speed and repeatability without compromising inspection accuracy. Although integrating a robotic setup fo…