Search results for "CEI"

Antécédents et conséquences de l'intrusion publicitaire perçue sur internet : le cas des formes publicitaires

2013

This research explores the relations between the format of advertising and perceived intrusion and tries to understand the consequences on attitudinal responses and on behaviour intentions of the Internet user, in particular in terms of resistance. The advertising intrusion is envisaged as a negative perception which could be activated by formats. The first part of this work is to understand the impact of perceived advertising intrusion, the second part is to operationalize the concept and test the research model.The study of the consequences of the use of ad formats allows reporting their influence on the advertising intrusion but also on the attitude towards the format and towards the ad.…

Flow-cytometric screening for the modulation of receptor-mediated endocytosis in human dendritic cells: implications for the development of an in vit…

1997

The aim of this study was to explore the usefulness of human blood dendritic cells (DC) in the development of an in vitro model for predictive testing of contact sensitizers. A method was established to monitor the influence of chemicals on the intracellular targeting of antibody-crosslinked MHC class II molecules after their uptake by human DC. Using a three-colour flow-cytometric technique, freshly prepared DC were distinguished from other MHC class II-bearing cell types such as B-cells and monocytes in unseparated mononuclear cell suspensions of healthy volunteers. The assay is based on the pH-sensitivity of internalized fluorescein-coupled MHC class II specific antibodies. Quenching of …

Diagnosis and therapeutic management of primary headache in an emergency setting

2013

Peptidyl Vinyl Ketone Irreversible Inhibitors of Rhodesain: Modifications of the P2 Fragment.

2020

In this paper, we report the design, synthesis and biological investigation of a series of peptidyl vinyl ketones obtained by modifying the P2 fragment of previously reported highly potent inhibitors of rhodesain, the main cysteine protease of Trypanosoma brucei rhodesiense. Investigation of the structure-activity relationship led us to identify new rhodesain inhibitors endowed with an improved selectivity profile (a selectivity index of up to 22 000 towards the target enzyme), and/or an improved antitrypanosomal activity in the sub-micromolar range.

Kilohertz and Low-Frequency Electrical Stimulation With the Same Pulse Duration Have Similar Efficiency for Inducing Isometric Knee Extension Torque …

2017

International audience; Objective To test the hypotheses that, as compared with pulsed current with the same pulse duration, kilohertz frequency alternating current would not differ in terms of evoked-torque production and perceived discomfort, and as a result, it would show the same current efficiency.Design A repeated-measures design with 4 stimuli presented in random order was used to test 25 women: (1) 500-microsecond pulse duration, (2) 250-microsecond pulse duration, (3) 500-microsecond pulse duration and low carrier frequency (1 kHz), (4) 250-microsecond pulse duration and high carrier frequency (4 kHz). Isometric peak torque of quadriceps muscle was measured using an isokinetic dyna…

A holistic approach to manage environmental quality by using the Kano model and social cognitive theory

2020

International audience; Since its first proposition in 1984, the Kano model has been used extensively in a variety of contexts within industries and academic research demonstrating its wide applicability. The Kano model allows for describing the relationship between an objective aspect and a subjective aspect. Yet is this relevant for environmental quality as well? In this study, we explore the cases where the Kano model is used for assessing environmental quality and its perception by consumers and identify the potential influencing factors for its application with this respect. We find that the Kano model can serve as an effective tool for converging towards environmental quality and sust…

Intention to use mobile customer relationship management systems

2014

Purpose – The purpose of this paper is to investigate the behavioral intentions of business-to-business (B2B) sales managers to use mobile customer relationship management (CRM) systems in the course of their day-to-day activities. Design/methodology/approach – An extended Technology Acceptance Model (TAM) of mobile CRM system adoption is developed and tested with data from 105 international sales managers representing five B2B companies. Findings – The study extends the TAM framework with three additional constructs derived from mobile technology and sales force automation literature, namely personal innovativeness in the domain of IT, perceived risk, and perceived reachability. The model…

Izoniazīda un nikotīnamīda kokristāli ar karbonskābēm

2016

Iegūti jauni izoniazīda un nikotīnamīda kokristāli ar karbonskābēm, pētītas to fizikāli ķīmiskās īpašības un kristāliskās struktūras. Kokristālu īpašības analizētas saistībā ar to kristāliskajām struktūrām, skaidrojot likumsakarības starp tām. Kokristālu iegūšanai izstrādāta tvaikķīmiskā metode, izvērtējot šķīdinātāja un kokristāla veidotāja īpašību ietekmi uz kokristalizācijas procesu. Veikta izoniazīda–benzoskābes kokristāla mehanoķīmiskas un patvaļīgas veidošanās izpēte, izvērtējot relatīvā mitruma, temperatūras un mehanoķīmiskās aktivācijas ietekmi. Ritvelda kvantitatīvās rentgenfāžu analīzes metode pielāgota kokristāla noteikšanai maisījumā ar izejvielām un nezināmas struktūras starppr…

Analysing the Impact of the Glass Ceiling in a Managerial Career: The Case of Spain

2021

The need to break down the barriers facing women in the labour market arouses great interest for reasons of social and sustainability justice. This study breaks new ground on the topic of the “glass ceiling” by assessing the evolution of gender inequality in the proportion of individuals reaching high managerial positions. The application of the csQCA method to a survey of two cohorts of Spanish graduates in management sharing the same starting conditions reveals two factors: job variety and additional education, as conditions that are usually present in a successful managerial career. Our findings confirm the prevalence of the gender gap with little progress in recent years. Women find it …

Inhibition of lactate export by quercetin acidifies rat glial cells in vitro

1997

The relationship between glial lactate release and glial intracellular pH (pH i) regulation is studied using C6 glioma cells and rat astrocytes in vitro, and the lactate transport inhibitors quercetin and a-cyano-4-hydroxycinnamate (CHC). pHi is measured using 2′,7′bis(carboxyethyl)-5,6-carboxyfluorescein (BCECF). The results show that lactate release is mediated partly by a specific lactate transport system inhibitable by quercetin (50 mM), but not by CHC (5 mM). Inhibition by quercetin results in a significant 3‐4-fold increase of intracellular lactate and a decrease of intracellular pH to 6.9. A participation of quercetin-inhibitable lactate transport in glial pHi-regulation is suggested…