Search results for "CEM"

Effect of simvastatin and/or pioglitazone on insulin resistance, insulin secretion, adiponectin, and proinsulin levels in nondiabetic patients at car…

2007

We investigated the effect of pioglitazone in comparison with and in combination with simvastatin on insulin resistance, plasma adiponectin, postprandial plasma glucose, insulin, and intact proinsulin levels in a nondiabetic population at cardiovascular risk. One hundred twenty-five nondiabetic patients at cardiovascular risk were randomized to pioglitazone (PIO), pioglitazone and simvastatin (PIO/SIM), or simvastatin (SIM) treatments. Blood samples were taken for the measurement of adiponectin and lipid levels. In addition, an oral glucose load with the measurements of glucose, insulin, and intact proinsulin levels was performed. Adiponectin levels increased from 14.0 ± 8.2 to 27.6 ± 14.5 …

Mandibular advancement devices: indications and predictors of treatment outcome. A review.

2007

Obstructive sleep apnea syndrome (OSAS) is a chronic sleep and respiratory disorder, which causes a partial or total obstruction of the air passage at the upper airway level. Mandibular advancement devices (MADs) have been used in the treatment of snoring, but may be a valid alternative to the continuous nasal positive airway pressure (CPAP) for certain OSAS cases. Therapy by means of MADs arises the interest of the scientific community and now there are many sleep-centres where dentists work as experts in sleep disorders. MADs are instruments of value because they are simple to use, reversible, portable and they generally have a low complication rate. They mechanically increase the orophar…

Italian Association of Sleep Medicine (AIMS) position statement and guideline on the treatment of menopausal sleep disorders

2019

Insomnia, vasomotor symptoms (VMS) and depression often co-occur after the menopause, with consequent health problems and reductions in quality of life. The aim of this position statement is to provide evidence-based advice on the management of postmenopausal sleep disorders derived from a systematic review of the literature. The latter yielded results on VMS, insomnia, circadian rhythm disorders, obstructive sleep apnea (OSA) and restless leg syndrome (RLS). Overall, the studies show that menopausal hormone therapy (MHT) improves VMS, insomnia, and mood. Several antidepressants can improve insomnia, either on their own or in association with MHT; these include selective serotonin reuptake …

Overcoming the barrier of CD8+ T cells: Two types of nano-sized carriers for siRNA transport

2019

Abstract Bioengineering immune cells via gene therapy offers treatment opportunities for currently fatal viral infections. Also cell therapeutics offer most recently a breakthrough technology to combat cancer. These primary human cells, however, are sensitive to toxic influences, which make the utilization of optimized physical transfection techniques necessary. The otherwise commonly applied delivery agents such as LipofectamineⓇ or strongly cationic polymer structures are not only unsuitable for in vivo experiments, but are also highly toxic to immune cells. This study aimed to improve the design of polymeric carrier systems for small interfering RNA, which would allow efficient internali…

UNA CONFIGURAZIONE SMART HERITAGE PER I CONTESTI EURO-MEDITERRANEI

La ricerca intende proporre una strategia urbana e tecnologica costituita da elementi smart che sviluppino una capacità di progettazione tecnologica integrata su scala urbana ed edilizia, sovrapponendo al disegno della città smart contemporanea quella della valorizzazione del patrimonio culturale attraverso le nuove Tecnologie dell’Informazione e della Comunicazione (TIC). Attraverso la schedatura di alcune esperienze smart di appendici che raccolgono le strategie urbane di recupero più significative e di un glossario finale con i termini ricorrenti nel settore, la Dottoranda propone un punto di vista del modello Smart City che si lega al tema della valorizzazione urbana fornendo a pianific…

A beam finite element for magneto-electro-elastic multilayered composite structures

2012

Abstract A new finite element based upon an elastic equivalent single-layer model for shear deformable and straight magneto-electro-elastic generally laminated beam is presented. The element has six degrees of freedom represented by the displacement components and the cross-section rotation of its two nodes. The magneto-electric boundary conditions enter the discrete problem as work-equivalent forces and moments while the electro-magnetic state characterization constitutes a post-processing step. The element possesses the superconvergence property for the static problem of beams with uniform cross-section and homogenous material properties along the beam axis direction. Moreover, it is free…

Do Narcissists Self-Enhance? Disentangling the Associations Between Narcissism and Positive Versus Enhanced Self-Views Across Aspects of Narcissism, …

2020

Across psychological disciplines, grandiose narcissism and self-enhancement have been treated as two closely related constructs. However, empirical research has not yielded conclusive insights about their association: It is currently unclear whether self-views of narcissistic individuals are more enhanced, in comparison with some criterion value, or whether their self-views are simply more positive than those of less narcissistic individuals. We aimed to clarify this fundamental issue with regard to (a) different aspects of narcissism (narcissistic admiration and rivalry), (b) different content domains of self-views (agency and communion), and (c) different criteria against which self-perc…

L’évolution de la structure de financement des organisations muséales : éclairage sur le rôle des endowment funds

2011

Rompant avec une longue tradition de financement public, certaines grandes institutions muséales européennes voient la part de leur financement privé augmenter considérablement. Cette évolution s’accompagne de la possibilité d’investir cet argent sur les marchés financiers à travers des endowment funds. L’objectif de cet article est de proposer un éclairage sur ce nouveau moyen offert aux musées de gérer leur capital financier. Pour se faire, nous examinerons le système muséal américain où les endowments sont la règle. Cette analyse nous permettra de comprendre ce que recouvre cette notion, d’appréhender ses modalités de mise en oeuvre et de saisir les bénéfices et les risques auxquels les …

Religion and Social Integration ‘Crises’ in North Western Europe: Some Conclusions

2013

My investigation of religion-related social integration crises in four North West European societies in the period 2001–11 began with the English case and the riots in some Northern English cities of 2001. In concluding I shall start again with this case, bringing it together with the Dutch, French and Northern Irish evidence we have now considered, and with my findings across each of the dimensions examined (segregation, media, institutional forms of multiculturalism and secularism, far-right and post-liberal mobilisation and national cultural trauma). Since much attention has been given to factors which shape conflict and influence the construction of prejudice, and especially to the nega…

Italian and Spanish Students’ Perception on Use of Technology in Classrooms of Classics in Secondary School

2019

A society that is becoming increasingly digital must explore new ways of learning. In fact, digital technologies have an impact on the education through the development of more flexible learning environments adapted to the needs of a high-mobility society. To prepare future citizens to the needs of the digital labor market, recent educational reforms in Italy and Spain focused their attention on students’ Digital Competences. Therefore, we are interested in probing how students of classical studies in Italian and Spanish high schools perceive the use of new technologies in the classroom. It is important to investigate classics at school, because traditionally this program is perceived as le…