Search results for "CEO"

A cryptochrome-based photosensory system in the siliceous sponge Suberites domuncula (Demospongiae)

2010

Based on the light-reactive behavior of siliceous sponges, their intriguing quartz glass-based spicular system and the existence of a light-generating luciferase [Muller WEG et al. (2009) Cell Mol Life Sci 66, 537–552], a protein potentially involved in light reception has been identified, cloned and recombinantly expressed from the demosponge Suberites domuncula. Its sequence displays two domains characteristic of cryptochrome, the N-terminal photolyase-related region and the C-terminal FAD-binding domain. The expression level of S. domuncula cryptochrome depends on animal’s exposure to light and is highest in tissue regions rich in siliceous spicules; in the dark, no cryptochrome transcri…

Molecular Biomineralization: Toward an Understanding of the Biogenic Origin of Polymetallic Nodules, Seamount Crusts, and Hydrothermal Vents

2011

Polymetallic nodules and crusts, hydrothermal vents from the Deep Sea are economically interesting, since they contain alloying components, e.g., manganese or cobalt, that are used in the production of special steels; in addition, they contain rare metals applied for plasma screens, for magnets in hard disks, or in hybrid car motors. While hydrothermal vents can regenerate in weeks, polymetallic nodules and seamount crusts grow slowly. Even though the geochemical basis for the growth of the nodules and crusts has been well studied, the contribution of microorganisms to the formation of these minerals remained obscure. Recent HR-SEM (high-resolution scanning electron microscopy) analyses of …

I sistemi di gestione ambientale per lo sviluppo eco-sostenibile del territorio: il caso delle Isole Eolie

2010

Looking for the origin of life in cosmochemistry : asteroids and their carbon-rich meteorites

2015

Carbonaceous chondrite meteorites are carbon-containing fragments of primitive asteroids that have offered the only samples available to date giving insights into chemical evolution in laboratory analyses. Their study has revealed that abundant organic chemistry came to be in the Solar System ahead of terrestrial life and, by the input of these meteorites and comets, might have aided in the origin of our planet’s biochemistry.

Notes on selected Cretaceous echinoids from south-central Sakhalin, Far East Russia

2013

AbstractFrom Albian, Santonian and Campanian strata in south-central Sakhalin, four echinoid taxa are described, illustrated and discussed. In Far East Russia, echinoids are rare constituents amongst mid- and Late Cretaceous macrofaunal assemblages in which inoceramid and non-inoceramid bivalves, plus heteromorph and non-heteromorph ammonites predominate. The sole regular species in the present lot is represented by an incomplete external mould of a primary spine of a rhabdocidarid,Polycidaris(?) sp., from the lower Campanian. Irregular taxa include a fragmentary, specifically indeterminate ‘pygurid’,Echinopygus(?) sp., of late Albian age, as well as two spatangoids. One of these, a toxaste…

NineTeen Complex-subunit Salsa is required for efficient splicing of a subset of introns and dorsal-ventral patterning

2020

© 2020 Rathore et al. This article is distributed exclusively by the RNASociety for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

Investigating the Molecular Mechanism of H3B-8800: A Splicing Modulator Inducing Preferential Lethality in Spliceosome-Mutant Cancers.

2021

The SF3B1 protein, part of the SF3b complex, recognizes the intron branch point sequence of precursor messenger RNA (pre-mRNA), thus contributing to splicing fidelity. SF3B1 is frequently mutated in cancer and is the target of distinct families of splicing modulators (SMs). Among these, H3B-8800 is of particular interest, as it induces preferential lethality in cancer cells bearing the frequent and highly pathogenic K700E SF3B1 mutation. Despite the potential of H3B-8800 to treat myeloid leukemia and other cancer types hallmarked by SF3B1 mutations, the molecular mechanism underlying its preferential lethality towards spliceosome-mutant cancer cells remains elusive. Here, microsecond-long a…

Solanum incanum and S. heteracanthum as sources of biologically active steroid glycosides: Confirmation of their synonymy

2012

A new spirostanol saponin (1), along with four known saponins, dioscin (2), protodioscin (3), methyl-protodioscin (4), and indioside D (5), and one known steroid glycoalkaloid solamargine (6) were isolated from the two synonymous species, Solanum incanum and S. heteracanthum. The structure of the new saponin was established as (23S,25R)-spirost-5-en-3β,23-diol 3-O-{β-D-xylopyranosyl-(1→2)-O-α-L-rhamnopyranosyl-(1→4)-[O-α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside}, by using a combination of 1D and 2D NMR techniques including (1)H, (13)C, COSY, TOCSY, NOESY, HSQC and HMBC experiments and by mass spectrometry. The compounds 1, 3, 4 and 5 were evaluated for cytotoxicity against five cancer c…

Prefazione

2020

A brief introduction to the History of Castelvetrano High School

CEO satisfaction and intended strategic changes

2018

How do CEOs react to attainment discrepancies in their organizations' performance? Scholars have generally argued that (only) when performance falls below a certain aspiration level do CEOs intend to change the organization's strategy. However, empirical evidence on this issue is ambiguous and inconclusive. We address this puzzle directly by studying how CEOs' cognitive interpretations of performance (their satisfaction with the firm's performance) affect the magnitude of intended strategic changes, and we explore the moderating effect of the context (performance compared to the industry) on this relationship. Using a sample of medium-sized organizations, we find that CEOs' satisfaction wit…