Search results for "CF"
showing 10 items of 701 documents
Suitability of the VOF Approach to Model an Electrogenerated Bubble with Marangoni Micro-Convection Flow
2022
When a hydrogen or oxygen bubble is created on the surface of an electrode, a micro-convective vortex flow due to the Marangoni effect is generated at the bottom of the bubble in contact with the electrode. In order to study such a phenomenon numerically, it is necessary to be able to simulate the surface tension variations along with a liquid-gas interface, to integrate the mass transfer across the interface from the dissolved species present in the electrolyte to the gas phase, and to take into account the moving contact line. Eulerian methods seem to have the potential to solve this modeling. However, the use of the continuous surface force (CSF) model in the volume of fluid (VOF) framew…
Synthesis of honokiol analogues and evaluation of their modulating action on VEGF protein secretion and telomerase-related gene expressions
2017
A group of 36 biphenyl derivatives structurally related to honokiol were synthesized by means of Suzuki coupling reactions. Their cytotoxicities were evaluated and compared to that of honokiol. Some of the compounds were then evaluated for their ability to downregulate the secretion of the VEGF protein and the expression of the VEGF, hTERT, and c-Myc genes; the two latter involved in the activation of telomerase in tumoral cells. Some of the synthetized derivatives showed promising pharmacological features as they exhibited IC50 values in low micromolar range, good therapeutic margins, and a multiple mode of action on tumor cells based on the inhibition of VEGF and, at the same time, of the…
VEGF-targeted therapy stably modulates the glycolytic phenotype of tumor cells
2014
Abstract Anti-VEGF therapy perturbs tumor metabolism, severely impairing oxygen, glucose, and ATP levels. In this study, we investigated the effects of anti-VEGF therapy in multiple experimental tumor models that differ in their glycolytic phenotypes to gain insights into optimal modulation of the metabolic features of this therapy. Prolonged treatments induced vascular regression and necrosis in tumor xenograft models, with highly glycolytic tumors becoming treatment resistant more rapidly than poorly glycolytic tumors. By PET imaging, prolonged treatments yielded an increase in both hypoxic and proliferative regions of tumors. A selection for highly glycolytic cells was noted and this met…
Synthesis of Combretastatin A-4 and 3′-Aminocombretastatin A-4 derivatives with Aminoacid Containing Pendants and Study of their Interaction with Tub…
2020
Natural product combretastatin A-4 (CA-4) and its nitrogenated analogue 3&prime
SVILUPPO DI METODOLOGIE DI PROGETTAZIONE INTEGRATA PER BARCHE A VELA DA COMPETIZIONE
2021
In questo lavoro di tesi sono presi in esame i metodi di progettazione integrata con riferimento al disegno nautico delle piccole imbarcazioni a vela da competizione. La progettazione di una barca a vela, in tutte le sue parti, è un processo molto complesso in quanto richiede una profonda esperienza in questo campo ed inoltre necessita di diverse competenze dal punto di vista tecnico in aree anche molto distanti tra loro. Nella vita di tutti i giorni spesso risolviamo problemi relativamente semplici e quindi troviamo la soluzione anche in modo intuitivo, in ingegneria solitamente si affrontano problemi un po’ più complessi e seguire una procedura strutturata aiuta molto per trovare soluzion…
Grietas del nuevo mundo
2002
Es una crítica de Román Gubern sobre "La ventana global", libro coordinado por Vidal-Beneyto en 2002 y publicado en la editoral Taurus.
Effects of a structured educational intervention in moderate-to-severe elderly asthmatic subjects.
2019
Background: Adherence to inhaled drugs is linked to patients’ satisfaction with their device, and an incorrect use can negatively affect the outcomes of asthma treatment. We speculated that this is particularly true in elderly asthmatic subjects. Aim: We performed a national pre-post interventional multicentre study, enrolling moderate-to-severe asthmatic subjects aged ≥65 years treated with fixed inhaled combination drugs by dry powder inhaler (DPI) or pressurized metered dose inhaler (pMDI). Adherence and critical errors were evaluated by means of validated questionnaires at first visit (V1) and after 3–6 months (V2). At V1, subjects underwent intensive training on the correct use of the…
Liberty winter gardens in Palermo: contamination from solar design
2020
At the end of the 19th century, the city of Palermo boasted a tradition of steel elements that could include the most beautiful railings and light steel structures of the time. The paper shows how the technological, formal and spatial aspects of the metallic construction was derived by the application of Central Europe areas examples to the local reality, providing notions on designs, experimentations and originalities. Canopies, verandas, winter gardens and orangeries are architectural elements in iron and glass that represent an added value for the building, they improve the life quality of the people who live there. In particular, in the Liberty architecture these elements took shape thr…
Membrane Deformation and Its Effects on Flow and Mass Transfer in the Electromembrane Processes
2019
In the membrane processes, a trans-membrane pressure (TMP) may arise due to design features or operating conditions. In most applications, stacks for electrodialysis (ED) or reverse electrodialysis (RED) operate at low TMP (<
Performance improvement of a Savonius water rotor with novel blade shapes
2021
Abstract Savonius water rotor is a prominent drag based turbine able to extract energy available in flowing water with low velocity like river streams, tidal currents or other man made water canals. However, in view of its low performance, an enhanced design of the rotor blades is necessary to better its efficiency. Therefore, the present study aims to improve the efficiency of Savonius rotor by changing the blade design. Different blade shapes were investigated numerically using computational fluid dynamics (CFD). Using conventional design, the peak power coefficient was found to be 0.166 at tip-speed ratio of 0.78. However, the peak power coefficient reaches 0.184 using the optimal blade …