Search results for "CIO"

showing 10 items of 25726 documents

Spatial learning and long-term memory impairments in RasGrf1 KO, Pttg1 KO, and double KO mice

2018

© 2018 The Authors.

0301 basic medicineMaleMemory Long-TermHippocampusSpatial learningBiologyHippocampusBarnes mazememory03 medical and health sciencesBehavioral Neuroscience0302 clinical medicineDiscrimination PsychologicalMemoryAnimalsPttg1Maze LearningChromosome separationOriginal ResearchMice KnockoutPCALong-term memoryras-GRF1spatial learningBrainBarnes mazeMice Inbred C57BLSecurin030104 developmental biologySecurinCervell Localització de funcionsMemory consolidationFemaleSignal transductionBeta cellRasGrf1Neuroscience030217 neurology & neurosurgerySignal Transduction
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Adherence to the Mediterranean diet is associated with better quality of life: data from the Osteoarthritis Initiative

2016

BACKGROUND The Mediterranean diet has positively influenced various medical conditions, but only a paucity of studies has considered the relation between the Mediterranean diet and quality of life (QOL) among people living in North America. OBJECTIVE We investigated whether a higher adherence to the Mediterranean diet (aMED) was associated with better QOL and decreased pain, stiffness, disability, and depression in a large cohort of North Americans from the Osteoarthritis Initiative. DESIGN aMED was evaluated through a validated Mediterranean diet score categorized into quintiles. Outcomes of interest were QOL [assessed with the 12-Item Short-Form Health Outcome Survey (SF-12)]; disability,…

0301 basic medicineMaleMultivariate analysisMediterranean dietCross-sectional studyMedicine (miscellaneous)MediterraneanLogistic regressionDiet MediterraneanBody Mass Index0302 clinical medicineMediterranean diet; depression; disability; pain; quality of life osteoarthritis initiativeQuality of lifeSurveys and Questionnaires030212 general & internal medicineNutrition and DieteticsCenter for Epidemiologic Studies Depression ScaleMiddle AgeddepressionFemalemedicine.medical_specialtyWOMACquality of life osteoarthritis initiativePaindepression Mediterranean diet quality of life osteoarthritis initiative pain disability03 medical and health sciencesNutritional Epidemiology and Public HealthMediterranean dietOsteoarthritismedicineHumansAged030109 nutrition & dieteticsbusiness.industryDietMediterranean diet; depression; disability; pain; quality of life osteoarthritis initiative; Aged; Body Mass Index; Cross-Sectional Studies; Energy Intake; Female; Humans; Linear Models; Logistic Models; Male; Middle Aged; Multivariate Analysis; North America; Osteoarthritis; Pain; Quality of Life; Socioeconomic Factors; Surveys and Questionnaires; Diet Mediterranean; Patient ComplianceCross-Sectional StudiesLogistic ModelsdisabilitySocioeconomic FactorsMultivariate AnalysisNorth AmericaPhysical therapyLinear ModelsQuality of LifePatient CompliancebusinessEnergy IntakeBody mass indexDemography
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Consumption of sugar-sweetened beverages and artificially sweetened beverages from childhood to adulthood in relation to socioeconomic status – 15 ye…

2018

Background In Norway, social inequalities in health and health-related behaviors have been reported despite the well-developed welfare state. The objective of the present study was to analyze; (i) the development in frequency of consumption of sugar-sweetened beverages (SSB) and artificially sweetened beverages (ASB) from childhood to adulthood; (ii) socioeconomic inequalities in the consumption of SSB and ASB using different indicators of socioeconomic status (SES); (iii) time trends in potential disparities in SSB and ASB consumption among different socioeconomic groups to assess the development in socioeconomic inequality from childhood to adulthood. Methods This study uses data from the…

0301 basic medicineMaleNon-Nutritive SweetenersDietary SugarsMedicine (miscellaneous)Sugar-sweetened beveragesCohort Studies0302 clinical medicineSurveys and QuestionnairesVegetablesMedicine030212 general & internal medicineChildlcsh:RC620-627Nutrition and DieteticsSchoolsNorwaylcsh:Public aspects of medicineTime trendsPeer reviewlcsh:Nutritional diseases. Deficiency diseasesSocioeconomic statuslanguageFemaleAdultAdolescentArtificially sweetened beveragesPhysical Therapy Sports Therapy and RehabilitationNorwegianClinical nutritionBeverages03 medical and health sciencesYoung AdultHumansSocial inequalitySocioeconomic statusConsumption (economics)030109 nutrition & dieteticsTime trendsbusiness.industryResearchRepeated measures designlcsh:RA1-1270Feeding Behaviorlanguage.human_languageDietSocial ClassSocioeconomic FactorsFruitSweetening AgentsLongitudinalbusinessSugarsDemographyFollow-Up StudiesInternational Journal of Behavioral Nutrition and Physical Activity
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INTU -related oral-facial-digital syndrome type VI: a confirmatory report

2018

Oral-facial-digital (OFD) syndromes are a subgroup of ciliopathies distinguished by the co-occurrence of hamartomas and/or multiple frenula of the oral region and digital anomalies. Several clinical forms of OFD syndromes are distinguished by their associated anomalies and/or inheritance patterns, and at least 20 genetic types of OFD syndromes have been delineated. We describe here a child with preaxial and postaxial polydactyly, lingual hamartoma, a congenital heart defect, delayed development and cerebellar peduncles displaying the molar tooth sign. Whole-exome sequencing and SNP array identified compound heterozygous variants in the INTU gene, which encodes a protein involved in the posi…

0301 basic medicineMalePathologymedicine.medical_specialtyCiliary basal bodyCompound heterozygosityCiliopathies03 medical and health sciencesIntraflagellar transportCPLANEGeneticsmedicineInheritance PatternsHamartomaHumansINTU[ SDV.GEN.GH ] Life Sciences [q-bio]/Genetics/Human geneticsGenetics (clinical)business.industryInfant NewbornInfantMembrane ProteinsOrofaciodigital Syndromesmedicine.diseasePhenotypeMagnetic Resonance ImagingCytoskeletal Proteins030104 developmental biology[SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human geneticsNGSoral-facial-digital syndromebusinessSNP array
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Trends in Food Habits and Their Relation to Socioeconomic Status among Nordic Adolescents 2001/2002-2009/2010

2016

BACKGROUND: In the Nordic countries, substantial policy and intervention efforts have been made to increase adolescents' consumption of fruit and vegetables and to reduce their intake of sweets and soft drinks. Some initiatives have been formulated in a Nordic collaboration and implemented at national level. In recent years, social inequalities in food habits have been attracted particular governmental interest and several initiatives addressing the socioeconomic gradient in food habits have been highlighted. However, few internationally published studies have evaluated how trends in adolescents' food habits develop in the context of Nordic nutrition policy, or have compared differences bet…

0301 basic medicineMalePediatricsDenmarklcsh:MedicineSocial SciencesCarbonated BeveragesAdolescentsNutrition PolicyGeographical LocationsHabits0302 clinical medicineSociologySurveys and QuestionnairesFood choiceVegetablesMedicine and Health Sciences030212 general & internal medicinelcsh:ScienceMultidisciplinarySchoolsNorwayPublic Health Global Health Social Medicine and Epidemiologyta3142ruokatottumuksetEuropeNordic countriesravitsemuspolitiikkalanguageFemaleResearch Articlemedicine.medical_specialtyAdolescentContext (language use)Norwegianfood habitsScandinavian and Nordic CountriesSocial classDiet Surveyssosioekonominen asemaEducationDanishsocioeconomic status03 medical and health sciencesEnvironmental healthmedicineDietary CarbohydratesHumansSocial inequalitySocial StratificationSocioeconomic statusNutritionConsumption (economics)SwedenBehavior030109 nutrition & dietetics:Medisinske Fag: 700::Helsefag: 800 [VDP]business.industryEating Habitslcsh:REating habitsBiology and Life SciencesFeeding Behaviorlanguage.human_languageFolkhälsovetenskap global hälsa socialmedicin och epidemiologiSocial stratificationCross-Sectional StudiesLogistic ModelsSocial ClassSocioeconomic FactorsAge GroupsFruitPeople and Placeslcsh:QPopulation GroupingsbusinessPLoS ONE
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Prospective cohort study of risk factors for extended-spectrum ß-lactamase-producing Escherichia coli urinary tract infections in elderly patients ad…

2017

Producción Científica

0301 basic medicineMalePediatricsmedicine.medical_specialtyMultivariate analysismedicine.drug_classUrinary system030106 microbiologyAntibioticsbeta-Lactamases03 medical and health sciences0302 clinical medicineRisk Factors32 Ciencias Médicaspolycyclic compoundsmedicinePrevalenceEscherichia coliHumans030212 general & internal medicineProspective StudiesRisk factorProspective cohort studyEscherichia coli InfectionsAgedHigh rateAged 80 and overInfeccionesbusiness.industryMedical recordGeneral Medicinebiochemical phenomena metabolism and nutritionbacterial infections and mycosesUniversity hospitalHospitalizationSpainUrinary Tract InfectionsbacteriaFemalebusinessBiomarkers
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Fasciola hepatica reinfection potentiates a mixed Th1/Th2/Th17/Treg response and correlates with the clinical phenotypes of anemia.

2016

Background: Fascioliasis is a severe zoonotic disease of worldwide extension caused by liver flukes. In human fascioliasis hyperendemic areas, reinfection and chronicity are the norm and anemia is the main sign. Herein, the profile of the Th1/Th2/Th17/Treg expression levels is analyzed after reinfection, correlating them with their corresponding hematological biomarkers of morbidity. Methodology/Principal findings: The experimental design reproduces the usual reinfection/chronicity conditions in human fascioliasis endemic areas and included Fasciola hepatica primo-infected Wistar rats (PI) and rats reinfected at 8 weeks (R8), and at 12 weeks (R12), and negative control rats. In a cross-sect…

0301 basic medicineMalePhysiologymedicine.medical_treatmentSnailslcsh:MedicineGene ExpressionImmune PhysiologyGene expressionMedicine and Health Scienceslcsh:ScienceImmune ResponseInnate Immune SystemMultidisciplinaryReverse Transcriptase Polymerase Chain ReactionFOXP3hemic and immune systemsImmunosuppressionEBI3AnemiaForkhead Transcription FactorsHematologyThymusInterleukin-10Interleukin 10medicine.anatomical_structureHelminth InfectionsCytokinesResearch ArticleNeglected Tropical DiseasesFascioliasisImmunologychemical and pharmacologic phenomenaSpleenBiologyTransforming Growth Factor beta103 medical and health sciencesImmune systemTh2 CellsGeneticsParasitic DiseasesmedicineFasciola hepaticaAnimalsRats WistarCell ProliferationInterleukinslcsh:RBiology and Life SciencesMolecular DevelopmentFasciola hepaticaTh1 CellsTropical Diseasesbiology.organism_classificationRats030104 developmental biologyCross-Sectional StudiesImmune SystemImmunologyTh17 Cellslcsh:QSpleenDevelopmental Biology
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Fluid and total water intake in a senior mediterranean population at high cardiovascular risk: demographic and lifestyle determinants in the PREDIMED…

2019

Purpose: We aimed to evaluate associations between compliance with recommendations for total water intake (TWI) and total water intake from fluids (TWIF), and some socio-demographic and lifestyle factors of a senior Mediterranean population at high cardiovascular risk. Methods: Cross-sectional analysis with data of 1902 participants from the PREDIMED-Plus study. A validated 32-item Spanish fluid-intake questionnaire was used to assess beverage consumption and water intake. Multivariable logistic regression models were used to assess the odds ratio (OR) and the 95% confidence interval (CI) for complying with European Food Safety Agency recommendations for TWI and TWIF according to various so…

0301 basic medicineMaleRiskTotal water intake (TWI)Mediterranean dietPopulationHealth BehaviorDrinkingMedicine (miscellaneous)030209 endocrinology & metabolismLogistic regressionBeverages03 medical and health sciences0302 clinical medicineWho recommendationsSex FactorsEnvironmental healthMediterranean dietMedicineHumansWater intakeFluid intakeeducationGeriatric AssessmentLife StyleBeverages Fluid intake Mediterranean diet Total water intake (TWI)Agededucation.field_of_study030109 nutrition & dieteticsNutrition and Dieteticsbusiness.industryDrinking WaterOdds ratioMiddle AgedPredimedConfidence intervalSociological FactorsCross-Sectional StudiesCardiovascular DiseasesSpainFemalebusiness
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Epidemiology of rare cancers and inequalities in oncologic outcomes

2019

Rare cancers epidemiology is better known compared to the other rare diseases. Thanks to the long history of the European population-based cancer registries and to the EUROCARE huge database, the burden of rare cancers has been estimated the European (EU28) population. A considerable fraction of all cancers is represented by rare cancers (24%). They are a heterogeneous group of diseases, but they share similar problems: uncertainty of diagnosis, lack of therapies, poor research opportunities, difficulties in clinical trials, lack of expertise and of centres of reference. This paper analyses the major epidemiological indicators of frequency (incidence and prevalence) and outcome (5-year surv…

0301 basic medicineMaleSettore MED/06 - Oncologia Medica0302 clinical medicineNeoplasmsEpidemiologyPrevalenceEurope ; Population-based cancer registry ; Rare cancersChildeducation.field_of_studyRelative survivalIncidence (epidemiology)IncidenceGeneral MedicineMiddle AgedSurvival RateEuropeHealthcare DisparitieOncology030220 oncology & carcinogenesisChild PreschoolFemaleHumanAdultmedicine.medical_specialtyAdolescentEurope; Population-based cancer registry; Rare cancers; Surgery; OncologyPopulationSocio-culturaleEurope Population-based cancer registry Rare cancers03 medical and health sciencesYoung AdultRare DiseasesAge DistributionRare DiseasemedicineHumansRare cancersHealthcare DisparitiesSex DistributioneducationPopulation-based cancer registrySurvival rateAgedbusiness.industryPublic healthInfant NewbornCancerRare cancerInfantmedicine.diseaseClinical trial030104 developmental biologyNeoplasmSurgerybusinessDemography
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Possible effects of a free, healthy school meal on overall meal frequency among 10–12-year-olds in Norway: the School Meal Project

2018

Abstract Objective To evaluate possible effects of intake of a free, healthy school meal on overall meal frequency among 10–12-year-olds in Norway. This was evaluated using a quasi-experimental school-based intervention study assessing children’s meal frequency retrospectively using a questionnaire in two elementary schools in the southern part of Norway in 2014/15. Multiple logistic regression analyses with breakfast, lunch, dinner, supper as dependent variables were used. Results A total of 164 children at baseline; 55 children in the intervention group and 109 children in the control group were included. The serving of a free school meal every day for 1 year did not improve the overall m…

0301 basic medicineMaleSupperFree school meallcsh:MedicineInterventionLogistic regressionGeneral Biochemistry Genetics and Molecular BiologyOddsVDP::Medisinske Fag: 700::Helsefag: 800::Ernæring: 81103 medical and health sciences0302 clinical medicineSurveys and QuestionnairesMedicineHumansFree school meal030212 general & internal medicineChildlcsh:Science (General)MealsChildrenlcsh:QH301-705.5Retrospective StudiesMeal030109 nutrition & dieteticsSchoolsbusiness.industryNorwaydigestive oral and skin physiologylcsh:RFood ServicesGeneral MedicineOdds ratioSchool mealConfidence intervalMeal frequencyResearch NoteLogistic ModelsLunchSocioeconomic Factorslcsh:Biology (General)FemalebusinessEnergy IntakeDemographylcsh:Q1-390BMC Research Notes
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