Search results for "CLU"
showing 10 items of 14395 documents
Molecular mechanisms of MYCN-dependent apoptosis and the MDM2-p53 pathway: an Achille’s heel to be exploited for the therapy of MYCN amplified neurob…
2012
The p53 oncosuppressor is very seldom mutated in neuroblastoma, but several mecha- nisms cooperate to its functional inactivation in this tumor. Increased MDM2 levels, due to genetic amplification or constitutive inhibition of p14ARF, significantly contribute to this event highlighting p53 reactivation as an attractive perspective for neuroblastoma treat- ment. In addition to its role in tumorigenesis, MYCN sensitizes untransformed and cancer cells to apoptosis. This is associated to a fine modulation of the MDM2-p53 pathway Indeed MYCN induces p53 and MDM2 transcription, and, by evoking a DNA damage response (DDR), it stabilizes p53 and its proapoptotic kinase Homeodomain Interacting Prote…
Testing the nature of the Λ(1520)-resonance in proton-induced production
2006
The $\Lambda(1520)$ resonance has been recently studied in a unitarized coupled channel formalism with $\pi\Sigma(1385)$, $K\Xi(1530)$, $\bar{K}N$ and $\pi\Sigma$ as constituents blocks. We provide a theoretical study of the predictions of this model in physical observables of the $pp\to pK^+K^-p$ and $pp\to pK^+\pi^0\pi^0\Lambda$ reactions. In particular, we show that the ratio between the $\pi^0\pi^0\Lambda$ and $K^-p$ mass distributions can provide valuable information on the ratio of the couplings of the $\Lambda(1520)$ resonance to $\pi\Sigma(1385)$ and $\bar{K}N$ that the theory predicts. Calculations are done for energies which are accessible in an experimental facility like COSY at …
Palvelun laatuun ja sen johtamiseen liittyvät ongelmat : esimerkkinä kylpylät
2003
La normativa europea sui prodotti pensionistici individuali paneuropei tra regolazione del mercato e automatizzazione dei servizi finanziari (Il Reg.…
2023
The essay comments on the recent European legislation on a pan-European Personal Pension Product which aims to remedy the poor development of the market for these products also in the light of the welfare state's crisis. The essay criticizes some choices of the European legislator as they contrast with the objective of creating a single competitive market for pan-European individual pension products; the choices of the regulation on the protection of savers are also criticized, and finally the essay assume that as a consequence of the choices of the European legislator intermediaries will bear the costs of financial inclusion.
Teacher's attitudes towards inclusion and the inclusion of students with emotional and behavioural disorders
2016
Inclusion is both a symbolic and a practically meaningful process inextricably inter-twined with equity, social and educational participation. Teachers are a fundamental part of this process. Therefore, their attitudes carry a dynamic, which, in turn can be linked to educational success and inclusive implementation. Students with emotional and behavioural disorders constitute a challenging and vulnerable group of students, often excluded from the educational setting, with severe academic and social consequences. The main objective of the current study was to explore teachers’ attitudes to-wards the inclusion of students with emotional and behavioural disorders, in primary and secondary educ…
Perfect Hashing Structures for Parallel Similarity Searches
2015
International audience; Seed-based heuristics have proved to be efficient for studying similarity between genetic databases with billions of base pairs. This paper focuses on algorithms and data structures for the filtering phase in seed-based heuristics, with an emphasis on efficient parallel GPU/manycores implementa- tion. We propose a 2-stage index structure which is based on neighborhood indexing and perfect hashing techniques. This structure performs a filtering phase over the neighborhood regions around the seeds in constant time and avoid as much as possible random memory accesses and branch divergences. Moreover, it fits particularly well on parallel SIMD processors, because it requ…
Satysfakcja ze współdziałania szkoły podstawowej z rodziną ucznia ze specjalnymi potrzebami edukacyjnymi w kształceniu inkluzyjnym
2022
Kształcenie inkluzyjne, obok integracyjnego i specjalnego (segregacyjnego), jest jedną z form kształcenia uczniów ze specjalnymi potrzebami edukacyjnymi (SPE) w Polsce. Zakłada ono edukację uczniów z różnymi cechami, np. z niepełnosprawnością w szkołach ogólnodostępnych. W procesie edukacyjno-terepeutycznym tej grupy uczniów istotną rolę odgrywają ich rodzice, dlatego też nieodzowne jest współdziałanie szkoły z rodziną ucznia. W niniejszym artykule poruszone zostało zagadnienie współdziałania szkoły podstawowej z rodziną ucznia ze SPE, zawężone do rodziców uczniów z orzeczeniem o potrzebie kształcenia specjalnego, które w Polsce może być wydane ze względu na niektóre rodzaje dysfunkcji rozw…
Is no One Left Behind? Inclusive Citizenship in Practices of Self-help Groups in Rural Tanzania
2023
The United Nations’ Sustainable Development Goals (SDGs) are based on the Agenda 2030 according to which ‘no one is left behind’, highlighting the need for inclusive citizenship at all levels. This article examines self-help groups in rural Tanzania as potential arenas for inclusive citizenship, which is defined as bottom-up practices of membership, participation, and livelihood enhancement. However, inclusive citizenship is also characterised by exclusions. Therefore, while acknowledging the important contribution of self-help groups for development, this article scrutinises the question of patterns of exclusion, first, in practices of self-help groups, and second, in the relationships bet…
INCLUSIVE DECISION MAKING: THE ONLINE COMMUNICATION CAMPAIGN AS AN EXAMPLE OF PARTICIPATIVE POLICY
2022
For decades, national states have confronted various challenges to the democratic form of government. In such a highly complex frame, the question is, can public participation to policymaking still be a way to reach a more effective governance? In this chapter, I will attempt to demonstrate how inclusive bottom-up decision-making could improve the results of single projects and of wider European public policies. In the first part, I describe the European frame in which inclusive policymaking was born; then, in the second part, I analyse the Oltre project and its results as an example of participatory practices.
"Table 0" of "Measurements of $t\bar{t}$ differential cross-sections of highly boosted top quarks decaying to all-hadronic final states in $pp$ colli…
2019
inclusive absolute differential cross-section at particle level