Search results for "CNO"
showing 10 items of 5223 documents
Polymeric nanoparticles for siRNA delivery: Production and applications
2017
Gene therapy through the use of siRNA and a polymeric carrier are becoming an efficient therapeutic option to conventional pharmaceutical formulations for the treatment of deadly diseases, such as cancer, pulmonary, ocular and neurodegenerative diseases. However, several considerations regarding the stability, formulation, and efficacy have to be faced up until these systems could be considered to be a marketable pharmaceutical products for to extend siRNA application to clinical practice. This review is focused on the key challenges of siRNA therapeutics, with special attention on the faced obstacles and on the formulation-related difficulties, providing a list of requirements needed for o…
Development of New Targeted Inulin Complex Nanoaggregates for siRNA Delivery in Antitumor Therapy.
2021
Here, a novel strategy of formulating efficient polymeric carriers based on the already described INU-IMI-DETA for gene material whose structural, functional, and biological properties can be modulated and improved was successfully investigated. In particular, two novel derivatives of INU-IMI-DETA graft copolymer were synthesized by chemical functionalisation with epidermal growth factor (EGF) or polyethylenglycol (PEG), named INU-IMI-DETA-EGF and INU-IMI-DETA-PEG, respectively, in order to improve the performance of already described “inulin complex nanoaggregates” (ICONs). The latter were thus prepared by appropriately mixing the two copolymers, by varying each component from 0 to 100 wt%…
Inulin Derivatives Obtained Via Enhanced Microwave Synthesis for Nucleic Acid Based Drug Delivery
2015
A new class of therapeutic agents with a high potential for the treatment of different socially relevant human diseases is represented by Nucleic Acid Based Drugs (NABD), including small interfering RNAs (siRNA), decoy oligodeoxynucleotides (decoy ODN) and antisense oligonucleotides (ASOs). Although NABD can be engineered to be specifically directed against virtually any target, their susceptibility to nuclease degradation and the difficulty of delivery into target tissues severely limit their use in clinical practice and require the development of an appropriate nanostructured delivery system. For delivery of NABD, Inulin (Inu), a natural, water soluble and biocompatible polysaccharide, wa…
UPTAKE OF SILICA COVERED QUANTUM DOTS ON LIVING CELLS: LONG TERM VITALITY AND MORPHOLOGY STUDY ON HYALURONIC ACID BIOMATERIALS
2015
In this work we prepared colloidal CdSe-CdS core-shell nanocrystal emitting @625 nm and, by a micro-emulsion procedure of water in oil inverse micelle, we encapsulated a single dot inside each silica sphere. In this way the nanoparticles became biocompatible, are simply to prepare and could be used also in a water based environment. Moreover, the silica shield is transparent to the wavelengths of interest.
Effect of the Si doping on the properties of AZO/SiC/Si heterojunctions grown by low temperature pulsed laser deposition
2020
Abstract The structural and photoelectrical properties of Al-doped ZnO (AZO)/SiC/p-Si and AZO/SiC/n-Si heterojunctions, fabricated at low temperature by pulsed laser deposition, were investigated by means of a number of techniques. Raman analysis indicates that SiC layers have the cubic 3C-SiC phase, whilst X-ray diffraction measurements show that AZO films exhibit a hexagonal wurtzite structure, highly textured along the c-axis, with average crystallites size of 35.1 nm and lattice parameter c of 0.518 nm. The homogeneous and dense surface morphology observed by scanning electron microscopy was confirmed by atomic force microscopy images. Moreover, UV–Vis-NIR spectra indicated a high trans…
Recovering Sicilian Silk Heritage through Digital Technologies: The Case of Piraino’s Collection
2022
Textile conservation has given rise to small and medium-sized museums, usually with scarce resources. In Sicily, the little evidence that remains of silk production and opulent imports by the rich and powerful local aristocracy is kept in museums, parishes, and other cultural institutions. The documentation, dissemination, and enhancement of such a fragile heritage is today possible by means of technological tools that provide novel means to preserve, analyze, and exploit digital information. In this paper, we present some outcomes of the SILKNOW project, a project that applies computing research to the needs of diverse users (museums, educational institutions, the tourism industry, creativ…
Forme e Funzioni degli Elementi Tecnici nell'Architettura Contemporanea
2007
Il libro illustra, attraverso la rilettura critica e la rielaborazione grafica di particolari costruttivi relativi ad alcuni degli edifici contemporanei maggiormente significativi del panorama architettonico internazionale, forme e funzioni degli elementi tecnici caratterizzanti essenzialmente, e per materiali e per configurazione, l’involucro di tali edifici. In particolare vengono descritti gli elementi e/o gli strati funzionali che entrano in gioco nella definizione di elementi tecnici come pareti perimetrali verticali, coperture, infissi esterni, ma anche solai, controsoffitti, pavimenti sopraelevati, ecc evidenziando, attraverso lo schema di classificazione del sistema tecnologico dell…
Presència virtual de les universitats andaluses
2009
En aquest article exposarem de manera específica les iniciatives portades a terme en les universitats andaluses per fomentar, reforçar i estendre la seva presència virtual a la xarxa. Farem un recorregut pels serveis inculats amb la tecnologia i suport a l'ensenyament, els campus i aules virtuals presents en cadascuna d'aquestes universitats, així com pels esforços realitzats per La xarxa d'Universitats Virtuals Andaluzas per a la creació i desenvolupament del Campus Virtual Andaluz del qual formen part totes les universitats andaluses a través d'una àmplia oferta d'activitats d'ensenyament en línia.
Arquitectura de las FPGAs de Xilinx
2014
Las FPGAs se caracterizan por poseer recursos lógicos, constituidos por bloques lógicos configurables, repartidos por todo el circuito y por recursos de interconexión formados por líneas de interconexión y conexiones configurables. Además de profundizar en esta arquitectura, se presentan y definen las características principales de las FPGAs: gran capacidad de integración, arquitectura flexible que se adapta fácilmente a cada aplicación, poseen recursos específicos para la realización de circuitos aritméticos, presentan recursos lógicos específicos para realizar unidades de memoria internas y programación por descripción hardware, capacidad de trabajar varias aplicaciones en paralelo. Así m…
Herramienta de diseño para MicroBlaze: EDK
2014
Material docente perteneciente a la asignatura Sistemas Integrados que se imparte en el Máster Oficial de Ingeniería Electrónica de la ETSE-UV. Presentación de la plataforma EDK, la herramienta de diseño hardware que se emplea para gestionar los sistemas integrados de Xilinx. EDK permite la integración de los componentes hardware del Sistema Integrado y del código software para que los mismos actúen. También permite la Simulación, Depuración y Programación de todo el diseño. El material docente contiene un ejercicio práctico basado en crear una aplicación básica que nos permita acceder a cualquier periférico que se desee controlar con MicroBlaze. Para ello, se emplea XPS para generar la apl…