Search results for "COD"
showing 10 items of 2985 documents
Positioning Europe for the EPITRANSCRIPTOMICS challenge
2018
WOS: 000444092300018 PubMed ID: 29671387 The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built. This system is universal and is found in all kingdoms of life. However, bases in DNA and RNA can be chemically modified. In DNA, around 10 different modifications are known, and those have been studied intensively over the past 20years. Scientific studies on DNA modifications and proteins that recognize them gave rise to the large field of epigenetic and epigenomic research. The outcome of this intense research field is the discovery t…
Rilevanza critica di un'ermeneutica del testo scritto per la pedagogia fondamentale
2015
Il contributo presenta, in una prima parte, le tesi caratterizzanti dell'ermeneutica del testo scritto, elaborata da Paul Ricoeur e qui intesa come una poietica dell'esistenza. Ne mostra poi, nella seconda parte, il rilievo che esse possono assumere per la riflessione pedagogica sulla struttura e sul senso del metodo educativo - di quel metodo educativo che l'Autore propone e che denota il dialogo esistenziale centrato sull'empatia. In un paragrafo conclusivo, si riflette, più in generale, sul guadagno che la pedagogia fondamentale può ricevere da questo modello ermeneutico, nell'impegnativo compito di pensare la struttura che la costituisce come specifica scienza pedagogica.
Interaction between N-terminal domain of H4 and DNA is regulated by the acetylation degree.
1998
Abstract To study whether the acetylation of one or more of the four acetylatable lysines of histone H4 affects its binding to DNA, we have designed a protection experiment with a model system consisting in phage lambda DNA as substrate, Stu I as restriction endonuclease and histone H4 with different degrees of acetylation as the protective agent. It can be deduced from the experimental data that the protection afforded by the histone is not dependent on the number of positive charges lost by acetylation. Thus, non-acetylated H4 and mono-acetylated H4 cause similar protection, while di-acetylation of the histone seems to be the crucial step in significantly weakening the interaction between…
Gcn5p is involved in the acetylation of histone H3 in nucleosomes.
1997
Abstract Enzymatic extracts from a gcn5 mutant and wild-type strains of Saccharomyces cerevisiae were chromatographically fractionated and the histone acetyltransferase activities compared. When free histones were used as substrate, extracts from wild-type cells showed two peaks of activity on histone H3 but extracts from gcn5 mutant cells showed only one. With nucleosomes as substrate, the histone acetyltransferase activities present in extracts from the gcn5 mutant strain were not able to modify H3 whereas wild-type cell extracts acetylated intensely this histone. The activity that acetylated nucleosome-bound H3 behaved as a 170-kDa complex. We suggest that Gcn5p represents a catalytic su…
Escatologia occitana: riflessioni in margine ai racconti sull’Anticristo e sui Quindici segni del Giudizio
2014
Studio sul poema occitano Sens e razos d’una escriptura, un’opera composita che, commistionando e inglobando diverse ‘storie’ tratte da fonti differenti, prende sostanzialmente avvio da una traduzione-adattamento in versi abbastanza fedele del testo latino B dell’Evangelium Nicodemi1.
Sample details on OSL data for aeolian sediments in north-eastern part of European Sand Belt
2019
A compilation of previously published and unpublished absolute age (OSL and TL) determinations of aeolian sediments from the north-eastern part of European Sand Belt. Contains age, error, sampling depth, location etc. and a reference to data source. Coordinates of sampling locations for contemporary publications are taken from field observations (GPS), but older ones - published schematic maps. Data set is created according to schema of DATED-1 database (https://doi.org/10.1594/PANGAEA.848117).
Ethical Demands and Responsibilities in Online Publishing: The Finnish Experience
2014
Rapid advancement of online communication and publishing poses new challenges to media policy-makers and regulators for both statutory regulation and self-regulation. For journalists, ‘the Internet shapes and redefines a number of moral and ethical issues … when operating online or making use of online resources’ (Deuze and Yeshua, 2001: 276).
Planning Research Ethics
2015
This chapter will discuss why planning researchers of all kinds – faculty, students, consultants – need to be ethically sensitive. The chapter is written against a background of what has been termed an ‘”ethical” turn’ in many disciplines, and an increasing regulation (and bureaucratisation) of planning (and other) research conducted within universities. Ladd (1980,) argues that there are no ethical principles which are specific to any occupation. In this chapter we argue that the circumstances of planning research, at least, raise distinctive ethical issues . The chapter begins by considering the ethical dimensions of research practice. These will differ according to the way research pract…
Aristotle and Pedagogical Ethics
2020
The teacher’s pedagogical ethics refers to the Kantian maxims that a teacher is obliged to follow. One could provide a list of the most crucial maxims that a teacher must absolutely not violate. We surely need these Kantian maxims in the teachers’ pedagogical ethics, although they tell us very little about the properties that good and moral teachers should possess. In teacher education we must of course elaborate on the ethical code of the teacher (maxims), but we must also consider the properties of a morally good teacher. A good source in endeavouring to find these properties is the book Aristotle wrote over 2,000 years ago, Nicomachean Ethics. According to Aristotle, a virtuous citizen m…