6533b82afe1ef96bd128c43a
RESEARCH PRODUCT
Positioning Europe for the EPITRANSCRIPTOMICS challenge
Alessandro QuattroneJean-yves RoignantTuran DemircanMattia PelizzolaRaquel AlmeidaBojana BanovićVincent P. KellyRaffael SchaffrathPınar PirRupert G. FrayJasna BankovicMonica NeaguCarmen JerónimoFrank LykoClément CarréGordana TimotijevićVictoria H. CowlingSchraga SchwartzAndras DinnyesElzbieta PurtaGideon RechaviNikolaos A.a. BalatsosLuc WillemsDònal O’ CarrollVanessa ZammitArne KlunglandMichaela FryeMarieta CostacheAlberto DávalosStefan SelbertDenis L. J. LafontainePavel V. BaranovAlexandre DavidMark HelmJanis LiepinsAnastasis OulasJan KyselovicAndre VerdelFinn DrabløsManuel Macias-gonzalesMary A O'connellFrancois FuksM. SchaferMarie ÖHmanJernej UleFernando CardonaMichael F. JantschCécile Bousquet-antonelliHenrik NielsenStefan L. AmeresLuis Miguel ValorJohn Arne DahlStepanka VanacovaDuncan AyersYuri MotorinWalter RossmanithAyelet T. LammIrina Holodnuka KholodnyukEster BallanaJanusz M. Bujnickisubject
Epigenomics0301 basic medicine[SDV]Life Sciences [q-bio]Gene ExpressionDetection of RNA ModificationEpigenesis GeneticTranscriptomechemistry.chemical_compoundEcologyEvolution & EthologyNeoplasmsRNA NeoplasmEuropean FundingComputingMilieux_MISCELLANEOUSRNA Neoplasm/geneticsEpitranscriptomicsEpigenomicsStem CellsDNA NeoplasmNeoplasms/genetics[SDV] Life Sciences [q-bio]EuropeGene Expression Regulation NeoplasticDetection of RNA modificationGenetics & GenomicsComputational biologyBiologyBiochemistry & ProteomicsENCODE03 medical and health sciencesEpigenomics/standardsEpitranscriptomicsModel systemsHumansEpigeneticsDatabase of ModificationDNA Neoplasm/geneticsMolecular BiologyComputational & Systems BiologyEuropean funding[SDV.GEN]Life Sciences [q-bio]/GeneticsGene Expression ProfilingFOS: Clinical medicineNeurosciencesModel SystemsRNACell Biology030104 developmental biologychemistryGene Expression Profiling/methodsAlphabetTranscriptomeDNAdescription
WOS: 000444092300018 PubMed ID: 29671387 The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built. This system is universal and is found in all kingdoms of life. However, bases in DNA and RNA can be chemically modified. In DNA, around 10 different modifications are known, and those have been studied intensively over the past 20years. Scientific studies on DNA modifications and proteins that recognize them gave rise to the large field of epigenetic and epigenomic research. The outcome of this intense research field is the discovery that development, ageing, and stem-cell dependent regeneration but also several diseases including cancer are largely controlled by the epigenetic state of cells. Consequently, this research has already led to the first FDA approved drugs that exploit the gained knowledge to combat disease. In recent years, the similar to 150 modifications found in RNA have come to the focus of intense research. Here we provide a perspective on necessary and expected developments in the fast expanding area of RNA modifications, termed epitranscriptomics. COST Action [CA16120] This work was suppoerted by the COST Action, (CA16120).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-05-09 | RNA Biology |