Search results for "COD"
showing 10 items of 2985 documents
WWOX-related encephalopathies: delineation of the phenotypical spectrum and emerging genotype-phenotype correlation
2014
International audience; BACKGROUND:Homozygous mutations in WWOX were reported in eight individuals of two families with autosomal recessive spinocerebellar ataxia type 12 and in two siblings with infantile epileptic encephalopathy (IEE), including one who deceased prior to DNA sampling.METHODS:By combining array comparative genomic hybridisation, targeted Sanger sequencing and next generation sequencing, we identified five further patients from four families with IEE due to biallelic alterations of WWOX.RESULTS:We identified eight deleterious WWOX alleles consisting in four deletions, a four base-pair frameshifting deletion, one missense and two nonsense mutations. Genotype-phenotype correl…
Quantitative Transfer Function Approaches in Palaeoclimatic Reconstruction Using Quaternary Ostracods
2012
Abstract Quantifying (palaeo-)environmental changes is a key challenge for aquatic biological proxies, but the number of published transfer functions is increasing rapidly for the main palaeoecologically relevant groups such as diatoms and chironomids, and several transfer functions have also been developed during the past decades based on ostracod findings. The main environmental variables influencing the species assemblage composition in ostracod training sets are specific ion concentrations or ratios, salinity, water temperature and/or water depth. The available transfer functions and training sets are globally scattered, but often regionally restricted in their application. The most com…
OpenMolcas: From Source Code to Insight
2019
In this article we describe the OpenMolcas environment and invite the computational chemistry community to collaborate. The open-source project already includes a large number of new developments realized during the transition from the commercial MOLCAS product to the open-source platform. The paper initially describes the technical details of the new software development platform. This is followed by brief presentations of many new methods, implementations, and features of the OpenMolcas program suite. These developments include novel wave function methods such as stochastic complete active space self-consistent field, density matrix renormalization group (DMRG) methods, and hybrid multico…
Evaluation of the use of wavefront encoding to reduce depth-induced aberration in structured-illumination microscopy
2018
Three-dimensional imaging is affected by depth-induced spherical aberration (SA) when imaging deep into an optically thick sample. In this work, we evaluate the impact of SA on the performance of incoherent grating-projection structured illumination microscopy (SIM). In particular, we analyze the reduction of the contrast in the structured pattern and compare the reconstructed SIM images for different amounts of SA. In order to mitigate the impact of SA, we implement and evaluate in SIM a wavefront encoded imaging system using a square cubic (SQUBIC) phase mask, an approach shown previously to be successful in conventional microscopy.
Reducing effects of aberration in 3D fluorescence imaging using wavefront coding with a radially symmetric phase mask.
2016
In this work, a wavefront encoded (WFE) imaging system built using a squared cubic phase mask, designed to reduce the sensitivity of the imaging system to spherical aberration, is investigated. The proposed system allows the use of a space-invariant image restoration algorithm, which uses a single PSF, to restore intensity distribution in images suffering aberration, such as sample–induced aberration in thick tissue. This provides a computational advantage over depth-variant image restoration algorithms developed previously to address this aberration. Simulated PSFs of the proposed system are shown to change up to 25% compared to the 0 µm depth PSF (quantified by the structural similarity i…
MediaDASH Tool: Plataforma Web para la Codificación, Difusión y Recepción de Videos DASH
2017
[ES] Hoy en día el tráfico de video de internetsignifica alrededor del 65-70% del tráfico total. Se prevéque en 2019 aumente hasta el 80%. Debido a esto se hacenecesario optimizar y mejorar las tecnologías relacionadascon la transmisión de video para garantizar una calidad deexperiencia adecuada. Es por ello que se están desarrollando nuevos protocolos de transmisión de videoadaptativos basados en DASH. Debido a que su uso estáaumentando en los últimos años para realizar streamingsobre HTTP. En este artículo presentamos la herramientaMediaDASH Tool, la cual es una aplicación web quepermite de manera muy intuitiva poder comprimir ypreparar videos para su difusión con DASH. Así como suposteri…
Energy efficient and distributed resource allocation for wireless powered OFDMA multi-cell networks
2017
In this paper, we investigate the energy efficient resource allocation problem for the wireless powered OFDMA multi-cell networks. In the considered system, the users who have data to transmit in the uplink can only be empowered by the wireless power obtained from multiple base stations (BSs) with a large scale of multiple antennas in the downlink. A time division protocol is considered to divide the time of wireless power transfer (WPT) in the downlink and wireless information transfer (WIT) in the uplink into separate time slot. With the objective to improve the energy efficiency (EE) of the system, we propose the antenna selection, time allocation, subcarrier and power allocation schemes…
L’accertamento del trasferimento d’azienda in caso di cambio di appalto nel rito “Fornero”
2021
Con la sentenza n. 2315/2020 la Suprema Corte ha affermato il principio che l’accertamento dell’anzianità di servizio conseguente ad un trasferimento d’azienda può essere affrontato nell’ambito del rito speciale di impugnazione del licenziamento introdotto dalla L. n. 92/2012. Nella decisione in commento la Corte ha altresì modo di dare continuità all’orientamento per cui la fattispecie traslativa si perfeziona anche in presenza di un mero passaggio di personale in forza di obbligo contrattuale o di legge. Infatti se in un determinato appalto di servizi un imprenditore subentra ad un altro e ne acquisisce il personale e i beni strumentali organizzati (cioè l’azienda), la fattispecie no…
Answering Schrödinger's "What Is Life?"
2020
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Modelling heat transfer-controlled cooling and freezing times: a comparison between computational values and experimental results
2013
Modelling of heat transfer-controlled cooling and freezing time predictions are very important for a good preservation of foodstuffs. In that regard, we used a computer code based on the finite-element method that allowed us to analyse the phase-change of various foodstuffs during their freezing. The model was exercised to predict process times. The results can be used to design high efficiency plants. In this work, the results predicted by the FEM program are compared with the experimental values given in technical literature.