Search results for "COMPLEX"
showing 10 items of 5889 documents
Design, synthesis and biological evaluation of new anticancer drugs: FGFR inhibitors
2021
Fibroblast growth factor receptors (FGFRs) constitute a family of tyrosine kinases receptors (RTKs) that exert pivotal physiological functions in human embryonic and adult tissues. Hyperactivated FGFR signaling drives tumorigenesis in multiple cancer types, including lung and brain cancers. Great effort has been laid on the development of new compounds that specifically target the FGFR axis. However, cancer cell- based and microenvironmental resistance mechanisms against FGFR inhibitors often arise and are currently poorly understood. Furthermore, FGFR-targeted therapy often presents different side effects, e due to the broad biological spectrum of the FGFR signaling axis as well as to its …
Characterization of Chlorolignins in Bleached Kraft Pulp Mill Effluents Using Elemental Analysis and Fingerprinting by CuO Oxidation And Hplc
1994
Abstract Elemental analyses and chemical degradation techniques were applied to characterize lignin compounds in different stages of the chlorine bleaching process and in total mill effluent. Ultrafiltration was used for separation of chlorolignins into three nominal molecular weight fractions. Alkaline CuO oxidation products were analyzed by HPLC with diode array detection. Major compounds were identified by reference to authentic compounds. For comparison, native lignins (MWL), kraft lignins, and humic substances were studied as well. The oxygen, carbon and organic chlorine contents were closely similar in the various mill samples and their fractions. In all mill samples, vanillin and 6-c…
Murine Model of Cytomegalovirus Latency and Reactivation
2008
Efficient resolution of acute cytopathogenic cytomegalovirus infection through innate and adaptive host immune mechanisms is followed by lifelong maintenance of the viral genome in host tissues in a state of replicative latency, which is interrupted by episodes of virus reactivation for transmission. The establishment of latency is the result of aeons of co-evolution of cytomegaloviruses and their respective host species. Genetic adaptation of a particular cytomegalovirus to its specific host is reflected by private gene families not found in other members of the cytomegalovirus group, whereas basic functions of the viral replicative cycle are encoded by public gene families shared between …
Differential response of neuronal cells to a fusion protein of ciliary neurotrophic factor/soluble CNTF-receptor and leukemia inhibitory factor
2002
Ciliary neurotrophic factor (CNTF) displays neurotrophic activities on motor neurons and neural cell populations both in vivo and in vitro. On target cells lacking intrinsic expression of specific receptor alpha subunits cytokines of the IL-6 family only act in the presence of their specific agonistic soluble receptors. Here, we report the construction and expression of a CNTF/soluble CNTF-receptor (sCNTF-R) fusion protein (Hyper-CNTF) with enhanced biological activity on cells expressing gp130 and leukemia inhibitory factor receptor (LIF-R), but not membrane-bound CNTF-R. At the cDNA level, the C-terminus of the extracellular domain of human CNTF-R (amino acids 1-346) was linked via a sing…
A rigidity theorem for the pair ${\cal q}{\Bbb C} P^n$ (complex hyperquadric, complex projective space)
1999
Given a compact Kahler manifold M of real dimension 2n, let P be either a compact complex hypersurface of M or a compact totally real submanifold of dimension n. Let \(\cal q\) (resp. \({\Bbb R} P^n\)) be the complex hyperquadric (resp. the totally geodesic real projective space) in the complex projective space \({\Bbb C} P^n\) of constant holomorphic sectional curvature 4\( \lambda \). We prove that if the Ricci and some (n-1)-Ricci curvatures of M (and, when P is complex, the mean absolute curvature of P) are bounded from below by some special constants and volume (P) / volume (M) \(\leq \) volume (\(\cal q\))/ volume \(({\Bbb C} P^n)\) (resp. \(\leq \) volume \(({\Bbb R} P^n)\) / volume …
Exceptional Configurations of Quantum Walks with Grover’s Coin
2016
We study search by quantum walk on a two-dimensional grid using the algorithm of Ambainis, Kempe and Rivosh [AKR05]. We show what the most natural coin transformation -- Grover's diffusion transformation -- has a wide class of exceptional configurations of marked locations, for which the probability of finding any of the marked locations does not grow over time. This extends the class of known exceptional configurations; until now the only known such configuration was the "diagonal construction" by [AR08].
Transport parameters for aroma compounds through i-carrageenan and sodium alginate-based edible films
2011
In an effort to produce more environmentally friendly materials, renewable and biodegradable biopolymers have been investigated as coating materials. Edible films obtained from i-carrageenan and sodium alginates have good mechanical characteristics, are emulsion stabilizers, and decrease oxygen transfer. The addition of lipids to form emulsified films decreases the water vapour transfer and could be used to encapsulate active substances or aroma compounds. The aim of this work was to measure permeability, sorption and diffusion coefficient of the n-hexanal and D-limonene aroma compounds through emulsified (wf) and non-emulsified (wof) i-carrageenan and sodium alginate-based films to finally…
Autosomal recessive mutations inTHOC6cause intellectual disability: syndrome delineation requiring forward and reverse phenotyping
2016
THOC6 is a part of the THO complex, which is involved in coordinating mRNA processing with export. The THO complex interacts with additional components to form the larger TREX complex (transcription export complex). Previously, a homozygous missense mutation in THOC6 in the Hutterite population was reported in association with syndromic intellectual disability. Using exome sequencing, we identified three unrelated patients with bi-allelic mutations in THOC6 associated with intellectual disability and additional clinical features. Two of the patients were compound heterozygous for a stop and a missense mutation, and the third was homozygous for a missense mutation; the missense mutations wer…
Magneto-Structural Properties and Theoretical Studies of a Family of Simple Heterodinuclear Phenoxide/Alkoxide Bridged MnIIILnIII Complexes : On the …
2018
A family of MnIIILnIII strictly dinuclear complexes of general formula [MnIII(μ-L)(μ-OMe)(NO3)LnIII(NO3)2(MeOH)] (LnIII = Gd, Dy, Er, Ho) has been assembled in a one pot synthesis from a polydentate, multipocket aminobis(phenol)ligand [6,6'-{(2-(1-morpholyl)ethylazanediyl)bis(methylene)}bis(2-methoxy-4-methylphenol)], Mn(NO3)2·4H2O, Ln(NO3)3· nH2O, and NEt3 in MeOH. These compounds represent the first examples of fully structurally and magnetically characterized dinuclear MnIIILnIII complexes. Single X-ray diffraction studies reveal that all complexes are isostructural, consisting of neutral dinuclear molecules where the MnIII and LnIII metal ions, which exhibit distorted octahedral MnN2O4 …
A bibliometric analysis of cultural heritage research in the humanities: The Web of Science as a tool of knowledge management
2023
AbstractSubstantial research on the topic of cultural heritage has been conducted over the past two decades. At the same time, the overall output volume of journals and citation metrics have become important parameters in assessing and ranking researchers’ performance. Even though the scholarly interest in cultural heritage has recently increased world-wide, a comprehensive analysis of the publication output volume and its correlation to the shift in the cultural heritage regime starting in 2003 is still lacking. The article aims to understand the role of Web of Science (WOS) as a tool of knowledge management in academia by drawing on the scholarly output volume, the patterns displayed by t…