Search results for "CONST"
showing 10 items of 7706 documents
Improving Dissolution Behavior and Oral Absorption of Drugs with pH-Dependent Solubility Using pH Modifiers: A Physiologically Realistic Mass Transpo…
2021
Orally dosed drugs must dissolve in the gastrointestinal (GI) tract before being absorbed through the epithelial cell membrane. In vivo drug dissolution depends on the GI tract's physiological conditions such as pH, residence time, luminal buffers, intestinal motility, and transit and drug properties under fed and fasting conditions (Paixao, P. et al. Mol. Pharm. 2018 and Bermejo, et al. M. Mol. Pharm. 2018). The dissolution of an ionizable drug may benefit from manipulating in vivo variables such as the environmental pH using pH-modifying agents incorporated into the dosage form. A successful example is the use of such agents for dissolution enhancement of BCS class IIb (high-permeability,…
Kinetics of the intestinal uptake of zinc acexamate in normal and zinc-depleted rats.
1990
Abstract The uptake of zinc as acexamic acid salt in the small intestine of the anaesthetized rat was shown to be a two-phase process in normal animals. The first phase is rapid mucosal binding which satisfies the Freundlich isotherm equation and which involves about 30 per cent of the initially perfused zinc. The second phase was characterized as an apparent absorption step which obeys Michaelis-Menten and first-order combined kinetics, with the following parameters: Vm = 6.51 mg h−1; Km = 2.96 mg; ka = 0.306 h−1. In largely non-saturated conditions, an apparent global rate constant of about 2.50 h−1 was calculated. No significant interference due to endogenous zinc excretion into the smal…
Synthesis of polymeric derivatives of isoniazid: characterization and in vitro release from a water-soluble adduct with polysuccinimide.
1989
Coupling of isoniazid with polysuccinimide afforded a water-insoluble polymeric pro-drug; by reaction with ethanolamine it was chemically transformed in a water-soluble adduct. The in vitro release of isoniazid from the drug-polymer adduct was studied by using an artificial stomach wall lipid membrane. The transfer rate constant from simulated gastric juice to simulated plasma was defined and compared with that of an equivalent dose of pure drug.
Landfill gas upgrading with pilot-scale water scrubber: Performance assessment with absorption water recycling
2012
Abstract A pilot-scale counter current absorption process for upgrading municipal solid waste (MSW) landfill gas to produce vehicle fuel was studied using absorption, desorption and drying units and water as an absorbent. Continuous water recycling was used without adding new water to the system. The process parameters were defined by a previous study made with this pilot system. The effect of pressure (20–25 bar), temperature (10–25 °C) and water flow speed (5.5–11 l/min) on the upgrading performance, trace compounds (siloxanes, halogenated compounds) and water quality were investigated. Raw landfill gas flow was kept constant at 7.41 Nm3/h. Methane (CH4) and carbon dioxide (CO2) contents …
Synthesis, Characterization, and Electrochemistry of Open-Chain Pentapyrroles and Sapphyrins with Highly Electron-Withdrawing meso -Tetraaryl Substit…
2017
International audience; A series of open-chain pentapyrroles and sapphyrins with highly electron-withdrawing substituents (i.e., CN, CF3 , or CO2 Me) on the meso-phenyl rings was synthesized and characterized as to the spectral properties, protonation reactions, and electrochemistry in non-aqueous media. The investigated compounds are represented as (Ar)4 PPyH3 and (Ar)4 SapH3 where PPy and Sap correspond to the tri-anion of the open-chain pentapyrrole and sapphyrin, respectively, and Ar=p-CNPh, p-CF3 Ph, or p-CO2 MePh. UV/Vis and 1 H NMR spectroscopy as well as mass spectrometry data are given for the confirmation of the structures for the newly synthesized compounds. An X-ray structure fo…
Integrating the Real and Virtual World for Academic Language Education in Second Life
2013
This chapter focuses on a Second Language Acquisition (SLA) study conducted in virtual worlds that could help teachers in terms of knowledge about acquisition processes, in which technology is integration between formal and non formal education. The research comprises of two studies strongly focused on the development of Italian oral language proficiency. It was held within Second Life® (SL™)1 in order to explore the affordances of public spaces to enhance Intercultural Communicative Competence (ICC)2 and to stimulate the oral production through learner’s engagement. Since 2007, a new pilot project, Café Italia, was developed by Carmela Dell’Aria (aka Misy Ferraris) in Second Life®. Startin…
Promoting children’s participation: the role of teachers in preschool and primary school learning sessions
2010
The aim of this study is to provide insights into the social construction of participation in joint activities in Finnish preschool and primary school classrooms. The article deals with two issues: How do teachers promote participation in a preschool classroom as compared with a primary school classroom? What similarities and differences are found? It also considers the question of how the similarities contribute to the continuity from preschool to primary school in terms of participation. Based on observation data insights are provided into the interactions between teachers and children by using extracts from teacher‐led learning sessions. The teachers used a diversity of strategies to pro…
Adaptation and Validation of the Spanish Version of the Instrument to Evaluate Nurses’ Attitudes Toward Communication With the Patient for Nursing St…
2021
Communication is essential to quality of care and patient satisfaction. It has been linked to positive patient outcomes, increased engagement, improved health outcomes and safe practices. Given these benefits and the association between attitudes and behaviours, as behaviours can be predicted by studying attitudes, assessing nursing students' attitudes toward patient communication is critical as future nursing professionals. For this purpose, the main aim of this study was to adapt and validate an instrument to measure nurses´ attitudes towards communication (ACO) for nursing students. The attitudes towards communication with patients were analyzed. Then, differences in the dimensions of th…
Feasibility of using more polishable aggregates in dense-graded asphalt surface mixture: Case study of dolomite
2022
This study aimed to evaluate the feasibility of using more dolomite aggregates in asphalt surface mixtures that are typically used by West Virginia Division of Highways (WVDOH). The laboratory test results indicated that increasing dolomite content in asphalt surface mixtures resulted in a faster deterioration rate at the early polishing stage. In addition, asphalt surface mixtures containing more than 50% dolomite coarse aggregates would significantly reduce roadway safety. The field test results validated that dolomite shall not exceed 50% of coarse aggregate in asphalt surface mixture if the projected traffic volume is greater than 3.0 million equivalent single axle loads (ESALs).