Search results for "CONST"
showing 10 items of 7706 documents
Selfish vs. Unselfish Optimization of Network Creation
2005
We investigate several variants of a network creation model: a group of agents builds up a network between them while trying to keep the costs of this network small. The cost function consists of two addends, namely (i) a constant amount for each edge an agent buys and (ii) the minimum number of hops it takes sending messages to other agents. Despite the simplicity of this model, various complex network structures emerge depending on the weight between the two addends of the cost function and on the selfish or unselfish behaviour of the agents.
A Hooke's law-based approach to protein folding rate
2014
Kinetics is a key aspect of the renowned protein folding problem. Here, we propose a comprehensive approach to folding kinetics where a polypeptide chain is assumed to behave as an elastic material described by the Hooke[U+05F3]s law. A novel parameter called elastic-folding constant results from our model and is suggested to distinguish between protein with two-state and multi-state folding pathways. A contact-free descriptor, named folding degree, is introduced as a suitable structural feature to study protein-folding kinetics. This approach generalizes the observed correlations between varieties of structural descriptors with the folding rate constant. Additionally several comparisons am…
Quantum correlations in generalized spin star system
2006
The problem of detecting quantum signatures in the correlations formed in dynamical evolution of quantum bipartite systems receives a lot of attention in current literature. Generally speaking, the occurrence of correlations between two observables of a system does not necessarily reflect nonclassical behaviour. In this paper, the exact dynamics of a pair of uncoupled spins 1/2 interacting with a common spin 1/2 bath is investigated. Starting from a separable initial condition, the ability of the system to develop purely quantum correlations is brought to light. Physical interpretation of the concurrence function as well as a suggestion on how to measure it are given.
Electron Fabry-Perot interferometer with two entangled magnetic impurities
2007
We consider a one-dimensional (1D) wire along which single conduction electrons can propagate in the presence of two spin-1/2 magnetic impurities. The electron may be scattered by each impurity via a contact-exchange interaction and thus a spin-flip generally occurs at each scattering event. Adopting a quantum waveguide theory approach, we derive the stationary states of the system at all orders in the electron-impurity exchange coupling constant. This allows us to investigate electron transmission for arbitrary initial states of the two impurity spins. We show that for suitable electron wave vectors, the triplet and singlet maximally entangled spin states of the impurities can respectively…
A hypothetical model of the influence of inorganic phosphate on the kinetics of pyruvate kinase
2000
This paper presents a simple solution to the problem of approximating the calculated curve of reaction progress to the measured curve which is usually disturbed by initial oscillation of auxiliary lactate dehydrogenase (LDH) reaction. The experiments leading to the determination of the apparent Km for phosphoenolpyruvate (PEP) and Vm were performed. For precise estimation of kinetic parameters (Km and Vm) of the M1 isozyme of pyruvate kinase (PK), measured by coupling it to LDH reaction, the sequence of Michaelis‐Menten for pyruvate kinase and second-order kinetics for lactate dehydrogenase reaction as well as a non-zero initial concentration of lactate was assumed. The functions of apparen…
Misinterpretation risks of global stochastic optimisation of kinetic models revealed by multiple optimisation runs
2016
Abstract One of use cases for metabolic network optimisation of biotechnologically applied microorganisms is the in silico design of new strains with an improved distribution of metabolic fluxes. Global stochastic optimisation methods (genetic algorithms, evolutionary programing, particle swarm and others) can optimise complicated nonlinear kinetic models and are friendly for unexperienced user: they can return optimisation results with default method settings (population size, number of generations and others) and without adaptation of the model. Drawbacks of these methods (stochastic behaviour, undefined duration of optimisation, possible stagnation and no guaranty of reaching optima) cau…
Estimation of total electricity consumption curves by sampling in a finite population when some trajectories are partially unobserved
2019
International audience; Millions of smart meters that are able to collect individual load curves, that is, electricity consumption time series, of residential and business customers at fine scale time grids are now deployed by electricity companies all around the world. It may be complex and costly to transmit and exploit such a large quantity of information, therefore it can be relevant to use survey sampling techniques to estimate mean load curves of specific groups of customers. Data collection, like every mass process, may undergo technical problems at every point of the metering and collection chain resulting in missing values. We consider imputation approaches (linear interpolation, k…
Efficient change point detection in genomic sequences of continuous measurements
2010
Abstract Motivation: Knowing the exact locations of multiple change points in genomic sequences serves several biological needs, for instance when data represent aCGH profiles and it is of interest to identify possibly damaged genes involved in cancer and other diseases. Only a few of the currently available methods deal explicitly with estimation of the number and location of change points, and moreover these methods may be somewhat vulnerable to deviations of model assumptions usually employed. Results: We present a computationally efficient method to obtain estimates of the number and location of the change points. The method is based on a simple transformation of data and it provides re…
Special Civil Law as a Sign of Political Identity: A Constitutional Approach to the Case of the Valencian Community
2013
We seek to clarify the political terminology and meaning of what is contained in the Valencian Statute in the light of the (far more developed and diverse) doctrinal and jurisprudential contributions to arise from the demands of other autonomous communities. This is necessary after the 2006 reform of the Valencian Statute, due to the tendency towards historical law evident therein, and is also essential if progress is to be made towards the constitutional reform that will bring to a close the evolution of the Autonomous State into an ordered Federal State.
W cieniu trudnej przeszłości — kolejna odsłona kryzysu katalońskiego
2021
The purpose of this article is to present the repression that hit Catalonia during the Spanish Civil War (abolition of autonomy and return to centralism, criminal sentences of a political nature), thus showing that prudent political choices, dialogue, and mediation in Catalonia are a matter of utmost importance. Historical experiences should not become an element of political games but motivate a debate between the central government and the autonomous region on reforming the state system and improving cooperation mechanisms. For Catalonia, the dictatorship meant cancelling all republican legislation and judicial decisions and the annulment as well as annulling the Catalan autonomy statute …