Search results for "CQ"
showing 10 items of 1801 documents
Interleukin-9 and T helper type 9 cells in rheumatic diseases
2016
Summary Interleukin (IL)-9 is a 28-30 kDa monomeric glycosylated polypeptide belonging to the IL-7/IL-9 family of proteins that bind to a composite receptor consisting of the private receptor IL-9R and the IL-2 receptor, gamma (IL-2RG), a common gamma subunit shared by the receptors of many different cytokines. The IL-9R is expressed widely and IL-9 impacts a number of effector cells, such as effector T cells, B cells, innate lymphoid cells, mast cells, polymorphonuclear cells, epithelial cells and smooth muscle cells, playing an important role in regulating inflammatory immunity. The critical role of IL-9 in promoting cellular and humoral immune responses makes it an important focus of pot…
Subnational mapping of HIV incidence and mortality among individuals aged 15-49 years in sub-Saharan Africa, 2000-18: a modelling study
2021
Background. High-resolution estimates of HIV burden across space and time provide an important tool for tracking and monitoring the progress of prevention and control efforts and assist with improving the precision and efficiency of targeting efforts. We aimed to assess HIV incidence and HIV mortality for all second-level administrative units across sub-Saharan Africa. Methods. In this modelling study, we developed a framework that used the geographically specific HIV prevalence data collected in seroprevalence surveys and antenatal care clinics to train a model that estimates HIV incidence and mortality among individuals aged 15–49 years. We used a model-based geostatistical framework to e…
Label-Free Proteomics of Quantity-Limited Samples Using Ion Mobility-Assisted Data-Independent Acquisition Mass Spectrometry
2021
Over the past two decades, unbiased data-independent acquisition (DIA) approaches have gained increasing popularity in the bottom-up proteomics field. Here, we describe an ion mobility separation enhanced DIA workflow for large-scale label-free quantitative proteomics studies where starting material is limited. We set a special focus on the single pot solid-phase-enhanced sample preparation (SP3) protocol, which is well suited for the processing of quantity-limited samples.
Mast cells as initiators of immunity and host defense
2001
Until recently, mast cells have been viewed primarily as harmful because of their key role as effector cells of allergic and potentially lethal anaphylactic reactions. Their contribution to human health appeared instead to be limited to the elimination of parasites. There is, however, growing evidence for additional beneficial functions of mast cells, particularly regarding the initiation of acquired immune reactions. Thus, mast cells can phagocytize diverse particles, take up antigens, and express a number of receptors, particularly MHC class I and II antigens, ICAM-1 and -3, CD43, CD80, CD86 and CD40L which allow them to interact with T and B lymphocytes. They can also secrete numerous cy…
Time structure in men’s professional doubles tennis: does team experience allow finishing the points faster?
2021
This article provides information on the time structure of the doubles game in tennis and studies the influence of team experience on this time structure. The sample consisted of 2339 points corres...
Towards multilingual competence: examining beliefs and agency in first year university students’ language learner biographies
2021
As working life across the world is increasingly multilingual, multicultural and multidisciplinary, higher education language teaching is faced with a challenge of how to prepare students for it. Many universities have recently developed multilingual pedagogies but central to their success is learners’ perceptions of these practices. To fill this gap, this article explores first year university students’ language learner biographies to gain insight into how learners construct their linguistic realities. The biographies were studied with discourse analytical methods to examine the participants’ beliefs about language learning and their sense of agency in it. The results reveal that participa…
À la recherche du lexique de la gestion hôtelière : de la magdalena de Proust a la WebQuest
2020
This paper describes the creation and design of a series of activities aimed at learning the hotel management lexicon in French within a professional context. The tool used to frame these activities is the WebQuest, based on the principles of socioconstructivism and focused on promoting learning by discovery, among other aims. Accordingly, the action research methodology and after the Webquest implementation with a group of university students taking the French for Specific Purposes subject in a professional context, the study results are presented. Finally, the following conclusions derived from the results obtained allow: (1) to verify the adequacy and effectiveness of the tool created, …
Why Digital Games Can Be Advantageous in Vocabulary Learning
2021
Vocabulary learning is an integral part of language learning; however, it is difficult. Although there are many techniques proposed for vocabulary learning and teaching, researchers still strive to find effective methods. Recently, digital games have shown potentials in enhancing vocabulary acquisition. A majority of studies in digital game-based vocabulary learning (DGBVL) literature investigate the effectiveness of DGBVL tasks. In other words, there are enough answers to what questions in DGBVL literature whereas why questions are rarely answered. Finding such answers help us learn more about the structure of the DGBVL tasks and their effects on vocabulary learning. Hence, to achieve this…
Drawing conclusions about what co-participants know: Knowledge-probing question–answer sequences in new employee orientation lectures
2019
This study aims to uncover the processes of interaction through which knowledge acquisition in new employee orientation is monitored and controlled. Using video-recordings of orientation lectures as data, the study focuses on question–answer sequences in which the lecturer’s question probes into the state of the employees’ knowledge; in particular, it looks at the third turn of the sequence, in which the lecturer comes to a conclusion concerning the participants’ knowledge. This is shown to be an unavoidably practical accomplishment, which is contingent on both the often ambivalent responses of the participants and the design of the knowledge-probing question. Also, the lecturer orients to…
The emotional journey of being and becoming bilingual
2017
This article examines the foreign language learning biographies of six Finnish English speakers who reflect on their journey towards a bilingual identity. In this article language learning is examined as a process that is intrinsically emotional as emotion connects individuals with the world as well as being a movement within oneself. The data analysis is based on dialogical and narrative approaches. Through the analysis two key story types were named: Bilingualism as striving and Bilingualism as a gift. In the striving stories English was held up as an ideal, as a way of engaging with the wider world but moreover as a way of finding a better ‘me’. In the gift stories, English was experienc…