Search results for "CRO"
showing 10 items of 40106 documents
Évaluation ergonomique du serveur intranet Bull
1997
Rapport de contrat Bull INRIA; Évaluation par inspection du serveur intranet Bull
Annales des travaux des auditeurs de l'IHEDN 2006 : "Les évolutions récentes en Chine"
2006
CD rom; International audience
Recurrencia postquirúrgica en la Enfermedad de Crohn. Análisis de la variabilidad intra e interobservador del índice de Rutgeerts
2020
La cirugía continúa siendo un tratamiento disponible en la enfermedad de Crohn ileocólica, sin embargo, no es curativa y las lesiones reaparecen en la propia anastomosis o en el neoíleon en la mayoría de los pacientes, lo que se conoce como recurrencia postquirúrgica. Actualmente la colonoscopia es la técnica de elección para valorarla y el índice de Rutgeerts la única herramienta endoscópica disponible para graduar la actividad inflamatoria en cinco categorías (i0 sin lesiones hasta i4 lesiones graves). Debido a la heterogeneidad de las lesiones incluidas en la categoría i2 y a su pronóstico a largo plazo, se desarrolló el índice de Rutgeerts modificado que únicamente subdividió la categor…
Sialometaplasia Necrotizante: Presentación de cinco casos clínicos
2004
La sialometaplasia necrotizante (SN) es una afección inflamatoria, autoresolutiva, que afecta a las glándulas salivales, más frecuentemente a las menores. Si bien su etiopatogenia permanece aún desconocida, diversos autores sugieren que una agresión fisico-química o biológica sobre los vasos sanguíneos produciría isquemia, la cual conduciría al infarto de la glándula y su posterior necrosis. Su aspecto clínico e histológico tiene apariencias de malignidad. Clínicamente puede presentarse como una úlcera de bordes irregulares, ligeramente elevados y lecho necrótico, mientras que histopatológicamente se caracteriza por presentar metaplasia escamosa de conductos y acinos e hiperplasia pseudoepi…
Rubefacientu (mentola un niacīna) izraisīto mikrocirkulācijas reakciju novērtējums ādas dažādos dziļumos
2017
Ādai ir lokāla neiro-imuno-endokrīnā sistēma, kas lielā mērā atspoguļo organisma norises, kalpojot par sava veida „veselības indikatoru”. Īpaši pievilcīga un relatīvi pieejama ir ādas mikrocirkulācijas funkciju novērtēšana, ko var neinvazīvi veikt ar optiskām metodēm. Parasti praksē šādu reakciju novērtēšanai tiek lietoti standartizēti provokācijas testi, kā, piemēram, lokālas sildīšanas tests, vai acetilholīna jontoforēze. Taču bieži vien ādas sarežģītā mikrocirkulācija un liela regulācijas mehānismu daudzveidība apgrūtina rezultātu viennozīmīgu interpretāciju. Šajā kontekstā daudzsološa šķiet bispektrālā attēlveides fotopletizmogrāfija - optiska metode ar kuras palīdzību, izmantojot atšķi…
New polysaccharide-polyaminoacid hydrogels: a suitable strategy for colon-specific drug delivery
2007
The aim of this study was to prepare and characterize novel hydrogels with polysaccharide–polyaminoacid structure, able to undergo an enzymatic hydrolysis in the colon and potentially useful for treating inflammatory bowel diseases (IBD). Starting materials were methacrylated dextran (DEX-MA) and methacrylated α,β-poly(N-2-hydroxyethyl)-DL-aspartamide (PHM). These polymers were photocrosslinked by exposure of their aqueous solutions at 313 nm without photoinitiators. Different samples, shaped as microparticles, were obtained as a function of polymer concentration and irradiation time. FT-IR analysis confirmed the occurrence of a co-crosslinking between DEX-MA and PHM in all experimental con…
αβ defensin antimicrobial peptide (BPDEF) from the invasive red sea mussel Brachidontes pharaonis (P. Fischer, 1870)
2015
The immune system that plays a major role in determining host fitness in the wild, i.e. under the constraints imposed by ecology and life history. Permanent conflict interactions with the environment are the natural situation for a living creature. To partially resolve this, the immune system evolved and is characterized by an enormous variety of mechanisms and effectors, including the AMPs, although their specificity is poor. In fact, AMPs are universal and extremely successful in dealing with a huge range of pathogens, including bacteria, fungi, protozoa and viruses Amps are oligopeptides composed of varying number of amino acids with a broad spectrum of targeted organisms ranging from vi…
Photoluminescence properties of S2 molecule trapped in Melanophlogite
2015
We studied the photoluminescence properties of a sample of SiO2-clathrate Melanophlogite, a crystalline microporous material which is found in nature as a rare mineral. Upon β irradiation, the material displays an intense light emission under near-UV illumination. We studied in detail this optical activity by steady-state and time-resolved photoluminescence measurements as a function of temperature. The spectroscopic properties we find can be ascribed to a population of quasi-free molecules trapped within each of the two different types of cage available in the structure of this clathrate, although the spectroscopic properties of the guest molecules are affected by their interactions with t…
Characterization and antimicrobial activity of the volatile components of the flowers of Magydaris tomentosa (Desf.) DC. collected in Sicily and Alge…
2014
The essential oils of the flowers of Magydaris tomentosa (Desf.) DC. (Apiaceae) collected in Sicily (MSi) and Algeria (MAl), respectively, were obtained by hydrodistillation, and their compositions were analysed. The analyses allowed the identification and quantification of 23 components in MSi and 60 compounds in MAl, respectively, showing a very different profile in the composition of the two populations. The main components of MSi were cembrene (28.2%), α-springene (17.5%) and β-springene (14.8%), also present in MAl but in lesser amount (0.4%, 1.8% and 0.9%, respectively), whereas the principal constituents of MAl were (E)-nerolidol (35.4%), α-costol (13.3%) and β-costol (6.8%). Both MS…
Search for the Decay of the Higgs Boson to Charm Quarks with the ATLAS Experiment
2018
A direct search for the standard model Higgs boson decaying to a pair of charm quarks is presented. Associated production of the Higgs and Z bosons, in the decay mode ZH→ℓ+ℓ−c¯c is studied. A data set with an integrated luminosity of 36.1 fb−1 of pp collisions at √s=13TeV recorded by the ATLAS experiment at the LHC is used. The H→c¯c signature is identified using charm-tagging algorithms. The observed (expected) upper limit on σ(pp→ZH)×B(H→c¯c) is 2.7 (3.9+2.1−1.1) pb at the 95% confidence level for a Higgs boson mass of 125 GeV, while the standard model value is 26 fb.