Search results for "CTL"
showing 10 items of 521 documents
Processing and MHC class I presentation of human cytomegalovirus pp65-derived peptides persist despite gpUS2–11-mediated immune evasion
2007
Immune control of human cytomegalovirus (HCMV) infection can be mediated by CD8+cytolytic T lymphocytes (CTL). Adoptive transfer of antiviral CTL confers protection against HCMV reactivation and disease. The tegument protein pp65 and the immediate-early 1 protein (IE1) are recognized to be major CTL targets, even though during productive infection the viral immunoevasion proteins gpUS2–11 act to suppress major histocompatibility complex (MHC) class I-restricted antigen presentation. Thus it was not clear how infected cells could be labelled with antigenic peptides in the face of immunoevasion. We show here that the immunodominant peptide pp65NLVwas presented by MHC class I in cells infected…
Analytical modelling of force transmission in axially loaded RC columns with indirectly loaded jackets
2019
Abstract Concrete and steel jacketing are common strengthening techniques for reinforced concrete (RC) columns subjected to axial loads. In the most of cases the external jacket is made leaving gaps between the strengthening layer and the slabs, avoiding to carry directly a portion of the load. In this way, the external jacket induces a confinement pressure on the inner column, and its beneficial effect is due to the increase of strength and ductility. However, shear stresses develop on the interface between the column and consequently, the external jacket can be considered indirectly loaded. It sustains a portion of the axial load, which depends by the value of the axial shortening, relati…
A numerical approach to Blow-up issues for dispersive perturbations of Burgers' equation
2014
We provide a detailed numerical study of various issues pertaining to the dynamics of the Burgers equation perturbed by a weak dispersive term: blow-up in finite time versus global existence, nature of the blow-up, existence for "long" times, and the decomposition of the initial data into solitary waves plus radiation. We numerically construct solitons for fractionary Korteweg-de Vries equations.
Numerical Study of breakup in generalized Korteweg-de Vries and Kawahara equations
2010
This article is concerned with a conjecture by one of the authors on the formation of dispersive shocks in a class of Hamiltonian dispersive regularizations of the quasilinear transport equation. The regularizations are characterized by two arbitrary functions of one variable, where the condition of integrability implies that one of these functions must not vanish. It is shown numerically for a large class of equations that the local behaviour of their solution near the point of gradient catastrophe for the transport equation is described locally by a special solution of a Painlev\'e-type equation. This local description holds also for solutions to equations where blow up can occur in finit…
Deformations of semisimple Poisson pencils of hydrodynamic type are unobstructed
2015
We prove that the bihamiltonian cohomology of a semisimple pencil of Poisson brackets of hydrodynamic type vanishes for almost all degrees. This implies the existence of a full dispersive deformation of a semisimple bihamiltonian structure of hydrodynamic type starting from any infinitesimal deformation.
Nonlinear hyperbolic equations in surface theory: integrable discretizations and approximation results
2006
A numerical scheme is developed for solution of the Goursat problem for a class of nonlinear hyperbolic systems with an arbitrary number of independent variables. Convergence results are proved for this difference scheme. These results are applied to hyperbolic systems of differential-geometric origin, like the sine-Gordon equation describing the surfaces of the constant negative Gaussian curvature (K-surfaces). In particular, we prove the convergence of discrete K--surfaces and their Backlund transformations to their continuous counterparts. This puts on a firm basis the generally accepted belief (which however remained unproved untill this work) that the classical differential geometry of…
Numerical study of the transverse stability of the Peregrine solution
2020
We generalise a previously published approach based on a multi-domain spectral method on the whole real line in two ways: firstly, a fully explicit 4th order method for the time integration, based on a splitting scheme and an implicit Runge--Kutta method for the linear part, is presented. Secondly, the 1D code is combined with a Fourier spectral method in the transverse variable both for elliptic and hyperbolic NLS equations. As an example we study the transverse stability of the Peregrine solution, an exact solution to the one dimensional nonlinear Schr\"odinger (NLS) equation and thus a $y$-independent solution to the 2D NLS. It is shown that the Peregrine solution is unstable against all…
Numerical study of shock formation in the dispersionless Kadomtsev-Petviashvili equation and dispersive regularizations
2013
The formation of singularities in solutions to the dispersionless Kadomtsev-Petviashvili (dKP) equation is studied numerically for different classes of initial data. The asymptotic behavior of the Fourier coefficients is used to quantitatively identify the critical time and location and the type of the singularity. The approach is first tested in detail in 1+1 dimensions for the known case of the Hopf equation, where it is shown that the break-up of the solution can be identified with prescribed accuracy. For dissipative regularizations of this shock formation as the Burgers' equation and for dispersive regularizations as the Korteweg-de Vries equation, the Fourier coefficients indicate as …
Combinatorics of generalized Bethe equations
2012
A generalization of the Bethe ansatz equations is studied, where a scalar two-particle S-matrix has several zeroes and poles in the complex plane, as opposed to the ordinary single pole/zero case. For the repulsive case (no complex roots), the main result is the enumeration of all distinct solutions to the Bethe equations in terms of the Fuss-Catalan numbers. Two new combinatorial interpretations of the Fuss-Catalan and related numbers are obtained. On the one hand, they count regular orbits of the permutation group in certain factor modules over \({\mathbb{Z}^M}\), and on the other hand, they count integer points in certain M-dimensional polytopes.
Geometry of spaces of compact operators
2008
We introduce the notion of compactly locally reflexive Banach spaces and show that a Banach space X is compactly locally reflexive if and only if $\mathcal{K}(Y,X^{**})\subseteq\mathcal{K}(Y,X)^{**}$ for all reflexive Banach spaces Y. We show that X * has the approximation property if and only if X has the approximation property and is compactly locally reflexive. The weak metric approximation property was recently introduced by Lima and Oja. We study two natural weak compact versions of this property. If X is compactly locally reflexive then these two properties coincide. We also show how these properties are related to the compact approximation property and the compact approximation prope…