Search results for "CTL"
showing 10 items of 521 documents
Interleukin-7 matures suppressive CD127(+) forkhead box P3 (FoxP3)(+) T cells into CD127(-) CD25(high) FoxP3(+) regulatory T cells.
2011
We have identified a novel interleukin (IL)-7-responsive T cell population [forkhead box P3 (FoxP3(+) ) CD4(+) CD25(+) CD127(+) ] that is comparably functionally suppressive to conventional FoxP3(+) CD4(+) CD25(+) regulatory T cells (T(regs) ). Although IL-2 is the most critical cytokine for thymic development of FoxP3(+) T(regs) , in the periphery other cytokines can be compensatory. CD25(+) CD127(+) T cells treated with IL-7 phenotypically 'matured' into the known 'classical' FoxP3(+) CD4(+) CD25(high) CD127(-) FoxP3(+) T(regs) . In freshly isolated splenocytes, the highest level of FoxP3 expression was found in CD127(+) CD25(+) T cells when compared with CD127(-) CD25(+) or CD127(+) CD25…
186: Superior antitumor in vitro responses of allogeneic matched sibling compared to autologous patient CD8+ T cells
2007
Allogeneic cell therapy as a means to break immunotolerance to solid tumors is increasingly used for cancer treatment. To investigate cellular alloimmune responses in a human tumor model, primary cultures were established from renal cell carcinoma (RCC) tissues of 56patients. In three patients with stable RCC line and human leukocyte antigen (HLA)-identical sibling donor available, allogeneic and autologous RCC reactivities were compared using mixed lymphocyte/ tumor cell cultures (MLTC). Responding lymphocytes were exclusively CD8 + T cells, whereas CD4 + T cells or natural killer cells were never observed. Sibling MLTC populations showed higher proliferative and cytolytic antitumor respon…
Transverse instability of periodic and generalized solitary waves for a fifth-order KP model
2017
We consider a fifth-order Kadomtsev-Petviashvili equation which arises as a two-dimensional model in the classical water-wave problem. This equation possesses a family of generalized line solitary waves which decay exponentially to periodic waves at infinity. We prove that these solitary waves are transversely spectrally unstable and that this instability is induced by the transverse instability of the periodic tails. We rely upon a detailed spectral analysis of some suitably chosen linear operators.
Inductive Power Transfer for 100W battery charging
2013
Today, Inductive Power Transfer (IPT) is widely investigated to provide wireless battery charge. Potential applications range from a few Watts of handheld devices to kWatts of automotive applications. Despite of comfort and safety options, wireless charging features relatively poor power conversion efficiency. In the literature, several solutions are proposed addressing efficiency related issues. In this paper, a 100W wireless charging station for electric bikes which improves the power conversion efficiency is proposed. The magnetic structure design is analyzed thoroughly as well as the proposed power electronics system architectures of both the power transmitter and power receiver. The ef…
The tumor suppressor CYLD controls the function of murine regulatory T cells.
2012
Abstract CYLD was originally identified as a tumor suppressor gene mutated in familial cylindromatosis, an autosomal dominant predisposition to multiple benign neoplasms of the skin known as cylindromas. The CYLD protein is a deubiquitinating enzyme that acts as a negative regulator of NF-κB and JNK signaling through its interaction with NEMO and TNFR-associated factor 2. We have previously described a novel mouse strain that expresses solely and excessively a naturally occurring splice variant of CYLD (CYLDex7/8). In this study, we demonstrate that CYLD plays a critical role in Treg development and function. T cells of CYLDex7/8 mice had a hyperactive phenotype manifested by increased prod…
A tyrosinase nonapeptide presented by HLA-B44 is recognized on a human melanoma by autologous cytolytic T lymphocytes
1996
The human tyrosinase gene has been reported previously to code for two distinct antigens recognized on HLA-A2 melanoma cells by autologous cytolytic T lymphocytes (CTL). By stimulating lymphocytes of melanoma patient MZ2 with a subclone of the tumor cell line of this patient, we obtained a CTL clone that lysed this subclone but did not lyse other subcloncs of the Same melanoma cell line. The sensitive melanoma subclone was found to express a much higher level of tyrosinase than the others, suggesting that the antigen recognized bv the CTL might be encoded by tyrosinase. Transfection of a tyrosinase cDNA demonstrated that the CTL clone indeed recognized a tyrosinase product presented by HLA-…
Fredholm operator families ?II
1984
First, we give a characterization of semi-Fredholm operators (i.e. those which are left or right invertible modulo compact operators) on Hausdorff tvs which generalizes the usual one in the context of Banach spaces. Then we consider a class of semi-Fredholm operator families on tvs which include both the "classical" semi-Fredholm operator valued functions on Banach spaces (continuous in the norm sense), and families of the form T + Kn, where Kn is a collectively compact sequence which converges strongly to O. For these families we prove a general stability theorem.
Vibrations and oscillations of tri-soliton molecules in a mode-locked fiber laser
2018
We present numerical simulations highlighting internal oscillations and vibrations within tri-soliton molecules generated by a mode-locked fiber laser. We highlight major qualitative differences as compared to two-soliton molecules.
Numerical study of blow-up in solutions to generalized Kadomtsev-Petviashvili equations
2013
We present a numerical study of solutions to the generalized Kadomtsev-Petviashvili equations with critical and supercritical nonlinearity for localized initial data with a single minimum and single maximum. In the cases with blow-up, we use a dynamic rescaling to identify the type of the singularity. We present a discussion of the observed blow-up scenarios.
Wronskian representation of solutions of NLS equation, and seventh order rogue wave.
2012
This work is a continuation of a recent paper in which we have constructed a multi-parametric family of the nonlinear Schrodinger equation in terms of wronskians. When we perform a special passage to the limit, we get a family of quasi-rational solutions expressed as a ratio of two determinants. We have already construct Peregrine breathers of orders N=4, 5, 6 in preceding works; we give here the Peregrine breather of order seven.