Search results for "Caliza"
showing 10 items of 656 documents
Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes
2012
One mechanism by which disease-associated DNA variation can alter disease risk is altering gene expression. However, linkage disequilibrium (LD) between variants, mostly single-nucleotide polymorphisms (SNPs), means it is not sufficient to show that a particular variant associates with both disease and expression, as there could be two distinct causal variants in LD. Here, we describe a formal statistical test of colocalization and apply it to type 1 diabetes (T1D)-associated regions identified mostly through genome-wide association studies and expression quantitative trait loci (eQTLs) discovered in a recently determined large monocyte expression data set from the Gutenberg Health Study (1…
Binaural release from masking in forward-masked intensity discrimination: Evidence for effects of selective attention
2012
In a forward-masked intensity discrimination task, we manipulated the perceived lateralization of the masker via variation of the interaural time difference (ITD). The maskers and targets were 500 Hz pure tones with a duration of 30 ms. Standards of 30 and 60 dB SPL were combined with 60 or 90 dB SPL maskers. As expected, the presentation of a forward masker perceived as lateralized to the other side of the head as the target resulted in a significantly smaller elevation of the intensity difference limen than a masker lateralized ipsilaterally. This binaural release from masking in forward-masked intensity discrimination cannot be explained by peripheral mechanisms because varying the ITD l…
Immunohistological and immunoelectron microscopic identification of TNF alpha in normal human and murine epidermis.
1992
The presence, distribution and cellular localization of tumour necrosis factor-alpha (TNF alpha) were investigated in normal human and murine epidermis using immunohistological and immunoelectron microscopic methods with monoclonal and polyclonal antibodies. The immunostaining revealed an intercellular plasma membrane and cytoplasmic labelling of the epidermal keratinocytes, but no labelling of Langerhans cells, melanocytes and Merkel cells. Large amounts of TNF alpha were regularly found in the sebaceous glands. These findings demonstrate that epidermal keratinocytes and especially sebocytes produce and release TNF alpha and that this keratinocyte-derived cytokine may be important for the …
Morphological Alterations and Stress Protein Variations in Lung Biopsies Obtained from Autopsies of COVID-19 Subjects
2021
Molecular chaperones, many of which are heat shock proteins, play a role in cell stress response and regulate the immune system in various ways, such as in inflammatory/autoimmune reactions. It would be interesting to study the involvement of these molecules in the damage done to COVID-19-infected lungs. In our study, we performed a histological analysis and an immunomorphological evaluation on lung samples from subjects who succumbed to COVID-19 and subjects who died from other causes. We also assessed Hsp60 and Hsp90 distribution in lung samples to determine their location and post-translational modifications. We found histological alterations that could be considered pathognomonic for CO…
Single-Sided Deafness: Impact of Cochlear Implantation on Speech Perception in Complex Noise and on Auditory Localization Accuracy.
2017
Objective To assess auditory localization accuracy and speech reception threshold (SRT) in complex noise conditions in adult patients with acquired single-sided deafness, after intervention with a cochlear implant (CI) in the deaf ear. Study design Nonrandomized, open, prospective patient series. Setting Tertiary referral university hospital. Patients Eleven patients with late-onset single-sided deafness (SSD) and normal hearing in the unaffected ear, who received a CI. All patients were experienced CI users. Intervention Unilateral cochlear implantation. Main outcome measures Speech perception was tested in a complex multitalker equivalent noise field consisting of multiple sound sources. …
High Pressure Processing Impact on Alternariol and Aflatoxins of Grape Juice and Fruit Juice-Milk Based Beverages.
2021
High-pressure processing (HPP) has emerged over the last 2 decades as a good alternative to traditional thermal treatment for food safety and shelf-life extension, supplying foods with similar characteristics to those of fresh products. Currently, HPP has also been proposed as a useful tool to reduce food contaminants, such as pesticides and mycotoxins. The aim of the present study is to explore the effect of HPP technology at 600 MPa during 5 min at room temperature on alternariol (AOH) and aflatoxin B1 (AFB1) mycotoxins reduction in different juice models. The effect of HPP has also been compared with a thermal treatment performed at 90 °C during 21 s. For this, different juice models, or…
A Generative Model of the Mutual Escalation of Anxiety Between Religious Groups
2018
We propose a generative agent-based model of the emergence and escalation of xenophobic anxiety in which individuals from two different religious groups encounter various hazards within an artificial society. The architecture of the model is informed by several empirically validated theories about the role of religion in intergroup conflict. Our results identify some of the conditions and mechanisms that engender the intensification of anxiety within and between religious groups. We define mutually escalating xenophobic anxiety as the increase of the average level of anxiety of the agents in both groups over time. Trace validation techniques show that the most common conditions under which …
Modeling Radicalization and Violent Extremism
2020
Given public anxiety about radicalization and violent extremism, it is not surprising that these topics have grabbed the attention of so many scholars in recent years. However, some have expressed concern over the fact that only a few studies in this relatively new field contain empirical data or systematic data analysis or develop causal models of the mechanisms generating these phenomena. We believe that computational modeling and simulation techniques can make a significant contribution to this scientific literature and eventually provide new tools for improving policy analysis. Here we briefly describe (1) an integrative theory of violent extremism proposed by Kruglanski and colleagues …
The Electronic Structure of Hexagonal BaCoO3
1999
Abstract TB–LMTO–ASA band structure calculations within the local spin density approximation have been performed to explain the magnetic and transport properties of BaCoO3. The calculations predict a magnetic and metallic ground state as energetically favored. BaCoO3 shows no long-range magnetic ordering, however, and only poor conductivity. The magnetic energy is low and the compound shows glassy susceptibility behavior at low temperatures. From the band structure we find Mott–Hubbard localization to be unlikely, and instead propose Anderson localization as a possible origin of the observed behavior. Calculations on slightly distorted structures exclude the possibility of a Peierls distort…
Polar bosons in one-dimensional disordered optical lattices
2013
We analyze the effects of disorder and quasi-disorder on the ground-state properties of ultra-cold polar bosons in optical lattices. We show that the interplay between disorder and inter-site interactions leads to rich phase diagrams. A uniform disorder leads to a Haldane-insulator phase with finite parity order, whereas the density-wave phase becomes a Bose-glass at very weak disorder. For quasi-disorder, the Haldane insulator connects with a gapped generalized incommesurate density wave without an intermediate critical region.