Search results for "Cance"
showing 10 items of 12092 documents
Inflammatory response elements, glycan, and proteome profiles as salivary biomarkers for the early diagnosis of OSCC
2021
El cáncer oral, sobre todo el, carcinoma oral de células escamosas (COCE), es la neoplasia maligna más común en la cavidad oral que se caracteriza por un mal pronóstico y una baja tasa de supervivencia, cuando se diagnostica en estadios avanzados. Puede ser tratado de forma efectiva si se detecta en estadios iniciales, mejorando el pronóstico. Por tanto, tras la prevención, el diagnóstico precoz se ha convertido en el principal objetivo en el manejo del cáncer oral, dado su impacto positivo en la supervivencia y calidad de vida de estos pacientes. A menudo, los escasos síntomas iniciales pasan desapercibidos y la enfermedad se descubre en fases avanzadas, por lo que se requiere mejorar el d…
The matrix metalloproteinase and insulin-like growth factor system in oral cancer – a prospective clinical study
2017
Eik Schiegnitz,1 Peer W Kämmerer,2 Holger Schön,1 Christoph Gülle,1 Manfred Berres,3,4 Keyvan Sagheb,1 Bilal Al-Nawas5 1Department of Oral and Maxillofacial Surgery, Plastic Surgery, University Medical Center, Johannes Gutenberg University of Mainz, Mainz, 2Department of Oral and Maxillofacial Surgery, Plastic Surgery, University Medical Centre Rostock, Rostock, 3Department of Mathematics and Technology, University of Applied Sciences Koblenz, Remagen, 4Institute of Medical Biometry, Epidemiology and Informatics, Johannes Gutenberg University of Mainz, Mainz, 5Department of Oral and Maxillofacial Surgery, Plastic Surgery, University Medical Centre, Martin-Luther University Ha…
Advances in the endoscopic management of malignant biliary obstruction
2020
Biliary obstruction is common in pancreatobiliary malignancies and has a negative impact on the patient’s quality of life, postoperative complications, and survival rates. Particularly in the last decade, there has been enormous progress regarding the diagnostic and therapeutic options in patients with malignant biliary obstruction. Endoscopy has given a new insight in this direction and novel techniques have been developed for the better characterization and treatment of malignant strictures. We herein summarize the available data on the different endoscopic techniques, and clarify their role in the diagnosis and treatment of malignant biliary obstructive disease. Finally, we propose an al…
Skin surveillance attitudes and behaviors in relation to skin checks for early signs of skin cancer in a sample of secondary school students and teac…
2012
<p><strong>Background</strong>: Malignant melanoma (MM) can be readily treated in its earliest stages: survival rate, when detected early, is up to 95,0%. This justifies investigations on contributive factors and measures for precocious detection of skin tumors to improve early detection and to increase survival rates. The purpose of this survey was to collect information about knowledge, attitudes and behaviors on prevention in relation to skin checks for early signs of skin cancer on a sample of secondary school students and teachers.</p><p><strong>Methods</strong>: A sample of secondary school students and teachers from Palermo, was recruited usi…
Zachowania zdrowotne a poczucie własnej skuteczności i kontrola emocji u pacjentów z chorobami nowotworowymi
2018
Wprowadzenie. Indywidualne cechy osobowości każdego człowieka warunkują odmienną reakcję na wiadomość o chorobie nowotworowej, wpływają na wyniki jej leczenia, dalsze rokowanie, a także jakość życia chorego. W tym kontekście istotną rolę odgrywają zdolności kontroli emocji oraz poczucie własnej skuteczności, które jest siłą przekonania, że poprzez realizację określonych działań można osiągnąć wyznaczone cele. Cel. Ocena związku pomiędzy poczuciem własnej skuteczności, kontrolą emocji a zachowaniami zdrowotnymi u pacjentów cierpiących z powodu choroby nowotworowej. Materiały i metody. Badaniem objęto 148 chorych leczonych onkologicznie, którzy odpowiedzieli na pytania zawarte w metryczce ora…
ANAPLASTIC THYROID CANCER: A CASE SERIES WITH A WIDE SPECTRUM OF TREATMENT IN EMERGENCY
2019
Anaplastic thyroid carcinoma (ATC) is one of the most aggressive malignancies of the neck, and for the majority of these patients the cause of death is a compromised airway, metastatic disease, superior vena cava syndrome, asphyxiation, or exsanguination. In case of the airway being compromised, emergency treatment is mandatory but not well defined. We report 4 different kinds of acute presentation of complications. Anaplastic thyroid cancer; diagnostic, clinical and prognostic indication, evaluation of choice of treatment are discussed. The spectrum of treatment varies from observation and preservation of the airway from a tracheostomy to extensive surgery. When a potentially curative rese…
Traitements et cancer : systèmes d’informations et représentations d’un jeune public – étude comparative Stafford-Dijon
2015
Tumor-independent Detection of Inherited Mismatch Repair Deficiency for the Diagnosis of Lynch Syndrome with High Specificity and Sensitivity
2023
Lynch syndrome (LS) is the most common hereditary cancer syndrome. Early diagnosis improves prognosis and reduces health care costs, through existing cancer surveillance methods. The problem is finding and diagnosing the cancer predisposing genetic condition. The current workup involves a complex array of tests that combines family cancer history and clinical phenotypes with tumor characteristics and sequencing data, followed by a challenging task to interpret the found variant(s). On the basis of the knowledge that an inherited mismatch repair (MMR) deficiency is a hallmark of LS, we have developed and validated a functional MMR test, DiagMMR, that detects inherited MMR deficiency directly…
Dexamethasone premedication suppresses vaccine-induced immune responses against cancer
2020
ABSTRACT Glucocorticosteroids (GCS) have an established role in oncology and are administered to cancer patients in routine clinical care and in drug development trials as co-medication. Given their strong immune-suppressive activity, GCS may interfere with immune-oncology drugs. We are developing a therapeutic cancer vaccine, which is based on a liposomal formulation of tumor-antigen encoding RNA (RNA-LPX) and induces a strong T-cell response both in mice as well as in humans. In this study, we investigated in vivo in mice and in human PBMCs the effect of the commonly used long-acting GCS Dexamethasone (Dexa) on the efficacy of this vaccine format, with a particular focus on antigen-specif…
Convolutional neural networks in skin cancer detection using spatial and spectral domain
2019
Skin cancers are world wide deathly health problem, where significant life and cost savings could be achieved if detection of cancer can be done in early phase. Hypespectral imaging is prominent tool for non-invasive screening. In this study we compare how use of both spectral and spatial domain increase classification performance of convolutional neural networks. We compare five different neural network architectures for real patient data. Our models gain same or slightly better positive predictive value as clinicians. Towards more general and reliable model more data is needed and collection of training data should be systematic. peerReviewed