Search results for "Cardiac"
showing 10 items of 1495 documents
Comparative Analysis of Tagging and Feature-Tracking Cardiac MRI Techniques for the Evaluation of Cardiac Deformation
2020
[EN] Currently, there is a high prevalence of cardiovascular diseases, being the leading cause of mortality worldwide. Thus, a rapid and effective evaluation of the heart is increasingly relevant to diagnose the patient early and achieve appropriate treatment. For this reason, this study aims to compare myocardial deformation parameters such as circumferential strain (segmental, base, mid, apical and global) and global torsion values by the CMR tissue tagging reference technique in SPAMM cine images and the promising feature-tracking technique in b-SSFP cine images, in 31 healthy subjects and 35 patients diagnosed with infarct. The results obtained showed that there is a high agreement in t…
What are the benefits of a minimally invasive approach in frail octogenarian patients undergoing aortic valve replacement?
2016
Not available
Reduction of Cardiac Fibrosis by Interference With YAP-Dependent Transactivation
2022
Background: Conversion of cardiac stromal cells into myofibroblasts is typically associated with hypoxia conditions, metabolic insults, and/or inflammation, all of which are predisposing factors to cardiac fibrosis and heart failure. We hypothesized that this conversion could be also mediated by response of these cells to mechanical cues through activation of the Hippo transcriptional pathway. The objective of the present study was to assess the role of cellular/nuclear straining forces acting in myofibroblast differentiation of cardiac stromal cells under the control of YAP (yes-associated protein) transcription factor and to validate this finding using a pharmacological agent that interf…
Análisis de la microestructura del sistema de conducción cardíaco basado en histología y análisis de imagen. Descripción en el humano y otras especie…
2021
El sistema de conducción cardíaca es una estructura ramificada que permite el inicio y la rápida propagación de impulsos eléctricos que desencadenan la despolarización eléctrica del tejido miocárdico. Los nodos cardíacos son la fuente del impulso eléctrico que se transmite al corazón y la función principal del sistema de conducción ventricular es la activación eléctrica rápida de los ventrículos. El objetivo de este trabajo fue estudiar las características histológicas y morfométricas de los diferentes componentes del sistema de conducción cardiaco en humanos, cerdos, caballos y perros, así como sus posibles variaciones. Se utilizó un grupo de diez corazones de humanos, diez de cerdo, diez …
Tratamiento quirúrgico de la insuficiencia tricúspide tardia tras cirugía mitral previa: identificación de factores de riesgo de morbimortalidad peri…
2022
Introducción. La insuficiencia tricúspide (IT) tardía, tras la corrección previa de lesiones valvulares izquierdas, ha presentado históricamente una elevada mortalidad quirúrgica que varia, según publicaciones, entre el 14.6% y el 32%. En el inicio de la cirugía valvular apenas se realizaban reparaciones tricúspides concomitantes por la creencia generalizada de que esta IT mejoraba al corregir las lesiones valvulares izquierdas. Estudios posteriores han demostrado que, hasta en el 50% de estos pacientes a los que no se les realizaba ningún procedimiento sobre la válvula tricúspide (TRC), su IT residual progresaba hacia una IT moderada-severa. Debido a los malos resultados postoperatorios en…
Efectos de un programa de entrenamiento funcional sobre la variabilidad de la frecuencia cardiaca, la función ejecutiva y la capacidad condicional en…
2014
Efectos de un programa de entrenamiento funcional sobre la variabilidad de la frecuencia cardiaca, la función ejecutiva y la capacidad condicional en adultos mayores.
Tranexamic acid in cardiac surgery: Are low doses enough?
2020
OBJECTIVES Tranexamic acid is used to prevent hyperfibrinolysis and reduce postoperative bleeding and blood transfusions in on-pump cardiac surgery. We evaluate the efficacy of low or high dose tranexamic acid in a prospective cohort study conducted in Valencia. MATERIALS AND METHODS A total of 427 patients were recruited between January 2019 and January 2020, 207 in the Hospital General Universitario (low dose [LD]) and 220 in the Hospital Universitario y Politecnico La Fe (high dose [HD] and intermediate dose [ID]). We recorded the presence of hyperfibrinolysis on rotational thromboelastometry, intra- and postoperative administration of blood products, chest tube output within the first 1…
VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart
2014
Abstract Angiogenic growth factors have recently been linked to tissue metabolism. We have used genetic gain‐ and loss‐of function models to elucidate the effects and mechanisms of action of vascular endothelial growth factor‐B (VEGF‐B) in the heart. A cardiomyocyte‐specific VEGF‐B transgene induced an expanded coronary arterial tree and reprogramming of cardiomyocyte metabolism. This was associated with protection against myocardial infarction and preservation of mitochondrial complex I function upon ischemia‐reperfusion. VEGF‐B increased VEGF signals via VEGF receptor‐2 to activate Erk1/2, which resulted in vascular growth. Akt and mTORC1 pathways were upregulated and AMPK downregulated, …
VALORE PROGNOSTICO E DECISIONALE DEL VO2 DI PICCO PER L'INDICAZIONE AL TRAPIANTO DI CUORE IN PAZIENTI CON SCOMPENSO CARDIACO CRONICO E TERAPIA BETABL…
2008
METODI DI STUDIO DELLA VARIABILITA’ DELLA FREQUENZA CARDIACA
2010
La frequenza cardiaca (FC) è controllata dal sistema nervoso vegetativo. Il nodo senoatriale (SA) ha una frequenza propria di depolarizzazione spontanea conosciuta come “frequenza intrinseca” che rappresenta la frequenza misurata in assenza di impulsi simpatici o parasimpatici come si può ottenere con la denervazione o il blocco farmacologico. Nei soggetti normali la frequenza intrinseca è di circa 100 bpm e dipende dal sesso e dall’età ed è influenzata dall’esercizio fisico, l’ipossia e le variazioni di temperatura. I soggetti allenati a sport di resistenza hanno una frequenza intrinseca minore. Gli effetti del sistema simpatico e parasimpatico influenzano in maniera predominante la FC int…