Search results for "Carn"
showing 10 items of 371 documents
Paracrine Activation of Hepatic CB1 Receptors by Stellate Cell-Derived Endocannabinoids Mediates Alcoholic Fatty Liver
2008
SummaryAlcohol-induced fatty liver, a major cause of morbidity, has been attributed to enhanced hepatic lipogenesis and decreased fat clearance of unknown mechanism. Here we report that the steatosis induced in mice by a low-fat, liquid ethanol diet is attenuated by concurrent blockade of cannabinoid CB1 receptors. Global or hepatocyte-specific CB1 knockout mice are resistant to ethanol-induced steatosis and increases in lipogenic gene expression and have increased carnitine palmitoyltransferase 1 activity, which, unlike in controls, is not reduced by ethanol treatment. Ethanol feeding increases the hepatic expression of CB1 receptors and upregulates the endocannabinoid 2-arachidonoylglycer…
Rats with congenital hydronephrosis show increased susceptibility to renal ischemia‐reperfusion injury
2020
Abstract Many drug candidates have shown significant renoprotective effects in preclinical models; however, there is no clinically used effective pharmacotherapy for acute kidney injury. The failure to translate from bench to bedside could be due to misleading results from experimental animals with undetected congenital kidney defects. This study was performed to assess the effects of congenital hydronephrosis on the functional capacity of tubular renal transporters as well as kidney sensitivity to ischemia‐reperfusion (I‐R)‐induced injury in male Wistar rats. Ultrasonography was used to distinguish healthy control rats from rats with hydronephrosis. L‐carnitine or furosemide was administer…
Effect of inhibiting carnitine biosynthesis on male rat sexual performance.
2008
l-carnitine has a documented role as a cofactor in cellular energy metabolism and fatty acid beta-oxidation pathways and it has also been considered to function in reproductive biology. We investigated whether decreasing concentrations of L-carnitine using an inhibitor of its biosynthesis, mildronate (3-(2,2,2-trimethylhydrazinium)-propionate), would influence the sexual behavior or sperm quality in male rats. Mildronate treatment induced a significant decrease in carnitine concentration and an increase in gamma-butyrobetaine (GBB) concentration in both plasma and testes extracts. However, the expression of carnitine palmitoyltransferase I in testes and testosterone concentration in plasma …
Regulation of lipid flux between liver and adipose tissue during transient hepatic steatosis in carnitine-depleted rats
2007
Rats with carnitine deficiency due to trimethylhydrazinium propionate (mildronate) administered at 80 mg/100 g body weight per day for 10 days developed liver steatosis only upon fasting. This study aimed to determine whether the transient steatosis resulted from triglyceride accumulation due to the amount of fatty acids preserved through impaired fatty acid oxidation and/or from up-regulation of lipid exchange between liver and adipose tissue. In liver, mildronate decreased the carnitine content by approximately 13-fold and, in fasted rats, lowered the palmitate oxidation rate by 50% in the perfused organ, increased 9-fold the triglyceride content, and doubled the hepatic very low density …
Enhancement of activities relative to fatty acid oxidation in the liver of rats depleted of l-carnitine by d-carnitine and a γ-butyrobetaine hydroxyl…
1995
Abstract This study was designed to examine whether the depletion of l -carnitine may induce compensatory mechanisms allowing higher fatty acid oxidative activities in liver, particularly with regard to mitochondrial carnitine palmitoyltransferase I activity and peroxisomal fatty acid oxidation. Wistar rats received d -carnitine for 2 days and 3-(2,2,2-trimethylhydrazinium)propionate (mildronate), a non-competitive inhibitor of γ-butyrobetaine hydroxylase, for 10 days. They were starved for 20 hr before being sacrificed. A dramatic reduction in carnitine concentration was observed in heart, skeletal muscles and kidneys, and to a lesser extent, in liver. Triacylglycerol content was found to …
Breu, 1791, 05, 24
Com a tít. el començament del text In festo Beatae Mariae ab Incarnatione monialis conversae professae Ordinis Carmelitarum Excalceatarum, ejusdem Ordinis in Galliis Fundatricis = Oraciones para la Misa del dia de la fiesta de la Beata Maria de la Encarnacion, religiosa lega professa de la Orden de Carmelitas Descalzas, y Fundadora de la misma Orden en Francia, p. [5-6]. Decretum Parisien. seu Rothomagen. = Decreto causa de Paris o de Roan, p. [6-7 Precedeix al tít., esc. xil. del Papa Pius VI, flaquejat per grav. xil. de Sant Pere i Sant Pau Bandes, filets Text a 2 col Sign.: *4
Mascheramenti festivi in Sicilia
2022
I mascheramenti cerimoniali, che vanno dal semplice occultamento del viso al rivestimento del corpo con specifici indumenti e attributi, ricorrono più diffusamente, in Sicilia come altrove, nel periodo carnevalesco. A cortei e performances di mascherati si accompagnano comportamenti tesi a segnalare la temporanea sospensione o il rivolgimento delle norme sociali e culturali: i giuochi licenziosi, le danze pubbliche e i balli domestici, le questue e lo smodato consumo di peculiari cibi e di bevande, la produzione di rumori e di schiamazzi, le tenzoni, il dileggio delle autorità, i motteggi e gli scherzi d’ogni sorta. Tra le performances carnascialesche che meritano di essere ricordate: la pa…
Máscaras de Sicilia. Fotografías de Attilio Russo y Giuseppe Muccio
2022
I mascheramenti, al pari degli altri simboli rituali caratterizzanti le celebrazioni carnascialesche siciliane, paiono tutti riconducibili alla sintassi propria delle feste di chiusura e apertura di un ciclo ossia di rifondazione ciclica del tempo, e finiscono con il proporre l’istituto carnevalesco, nel suo complesso, come “modello esemplare” delle cerimonie di Capodanno. Una festa cioè che attraverso parole, immagini, gesti riesce a restituire la realtà attraverso la ricostituzione per simulazione del cerchio del tempo, cioè a garantire che il tempo continui ad esserci, simulandone e ripetendone la morte e la rinascita. Las mascaradas, al igual que los demás símbolos rituales que caracter…
On the phylogeny and zoogeography of the leptarctines (Carnivora, Mammalia)
1982
A restudy of the skull and mandible ofLeptarctus neimenguensis Zhai from the Middle Miocene of China and the preparation of its auditory region led to the recognition of new features. The most important among them is the presence of a small suprameatal fossa partly hidden in the bony mastoid process corresponding to the structure described inPlesiogale andParagale (Schmidt-Kittler 1981) and representing the most primitive type of the mustelid middle ear.
The Nature of Our Becoming: Genealogical Perspectives
2020
In the light of Philipp Sarasin's work in 'Darwin und Foucault: Genealogie und Geschichte im Zeitalter der Biologie', the article delineates a genealogically articulated naturally produced culture and a cultured nature and discusses the genealogical implications of a carnal, becoming self in a world that could rightly be justified "as an aesthetical phenomenon." The article demonstrates the historicity and processual materiality as a conceptual platform for a combination of the notions of experienced carnality and a socially constructed body, demonstrating such a historically embedded carnal body as a binding agent for the "social constructivist" and "biologist" approaches in sciences. Thus…