Search results for "Cell adhesion"

The Role of Lectins in Finfish: A Review

2019

The immune system of vertebrates involves both innate and acquired immune responses. The innate immunity is more generalized with robust response whereas the other has a highly specific response to infectious pathogens. Because of the lack of specialized lymphatic organs, innate immunity is an important mode of defense in fishes. The less specific innate immune system acts mainly through complement pathway which depends on pattern-based recognition of “self” and “non-self” targets by host lectins and associated proteins. This ultimately results in the clearance of target cells. Lectins are glycoproteins which possess at least one carbohydrate recognition domain (CRD) that specifically and r…

Control of endothelial cell adhesion to polymer surface by ion implantation

2001

The bio-compatibility of ion implanted polymers has been studied by means of in vitro attachment measurements of bovine aorta endothelial cells. The specimens used were polystyrene (PS), polyethylene (PE), polypropylene (PP) and expanded polytetrafluoroethylene (ePTFE). He+ and Ne+ ion implantation were performed at an energy of 150 keV with fluences between 1 × 1013 to 1 × 1017ions/cm2 at room temperature. Wettability was estimated by means of a sessile drop method. The chemical and physical structures of ion implanted polymers were investigated by contact angle measurements, atomic force microscopy and X-ray photoelectron spectroscopic analysis in relation to cell attachment behavior. The…

Glycopolymer Functionalization of Engineered Spider Silk Protein-based Materials for Improved Cell Adhesion

2014

Silk protein-based materials are promising biomaterials for application as tissue scaffolds, due to their processability, biocompatibility, and biodegradability. The preparation of films composed of an engineered spider silk protein (eADF4(C16)) and their functionalization with glycopolymers are described. The glycopolymers bind proteins found in the extracellular matrix, providing a biomimetic coating on the films that improves cell adhesion to the surfaces of engineered spider silk films. Such silk-based materials have potential as coatings for degradable implantable devices.

Derivatization of Plasma Polymerized Thin Films and Attachment of Biomolecules to Influence HUVEC-Cell Adhesion

2011

Biological evaluation of PLLA membranes, with different pore diameters, to stimulate cell adhesion and growth in vitro

2015

Polymeric membranes prepared via DIPS (Diffusion Induced Phase Separation) are widely studied and utilized as scaffolds for the regeneration of tissue. In this work, poly (L)-lactide membrane are prepared through a DIPS protocol starting from a ternary solution made of polymer, dioxane (solvent) and water (non-solvent). A three-dimensional, porous and mechanically stable membrane is desirable for ingrowth of human bronchial epithelial cells. Polymeric membranes prepared via DIPS (Diffusion Induced Phase Separation) are widely studied and utilized as scaffolds for the regeneration of tissue. In this work, poly (L)-lactide membrane are prepared through a DIPS protocol starting from a ternary …

Modulation Theory of Adhesion: Role of the Ectoenzymes Glycosidase and Glycosyltransferase

1986

It is amazing, but still plausible, that in all animal systems hitherto studied there is only one basic principle by which cell-cell recognition occurs. From sponges to higher eukaryotes there is only a small number of cell adhesion molecules which are involved in cell-cell adhesion. Specificities and histogenetic patterning are achieved by modulating processes acting on cell adhesion molecules. In sponges (secondary aggregation system) and in other eukaryotes, the activity and function of cell adhesion molecules are assumed to be modulated by enzymatic processes (glycosylation and deglycosylation). Strong evidence from experiments with sponges is available which indicates that modulation c…

Kultivierung humaner Zellen auf polymerbeschichteten Bioimplantaten?ein neues Konzept zur Verbesserung der Implantateigenschaften

2004

BACKGROUND AND PURPOSE Calcific degeneration with the resulting need for operative replacement remains the major drawback of bioprostheses. Previous studies have shown that cellular surface seeding decreases calcium uptake in vitro and in vivo, but complete coverage remains difficult to achieve. A new approach is presented, masking glutaraldehyde residues with a covalently bound polymer layer thus facilitating cell seeding. The aim of this study was to evaluate different polymers for their ability to promote surface cell adhesion and formation of complete monolayers. MATERIAL AND METHODS Ten ultrathin polymers, covalently bound to glass and exhibiting different physicochemical characteristi…

ChemInform Abstract: Glycopeptide Synthesis Using O-Pentafluorophenyluronium Salts as Novel Condensing Reagents.

2010

Pentafluorophenyluronium salts and related coupling reagents for the solid-phase synthesis of peptides and glycopeptides have been developed and employed in the synthesis of a glycopeptide sequence from the cell adhesion molecule E-CAD 1.

ChemInform Abstract: Synthetic Inhibitors of Cell Adhesion: A Glycopeptide from E-Selectin Ligand 1 (ESL-1) with the Arabino Sialyl Lewisx Structure.

2010

Microcirculatory Dysfunction Induced by Cigarette Smoking

2000

This review deals with the deleterious effects of cigarette smoking on the microcirculation, both in terms of morphological (i.e., vessel wall injury, capillary loss) and functional aspects. The latter concerns predominantly changes in tissue perfusion and its regulatory mechanisms (i.e., reactive hyperemia, sequestration of blood cells in the microcirculation). The mechanisms of action of cigarette smoking on the microcirculation include compromised endothelial-dependent vasorelaxation, platelet aggregation, endothelial cell dysfunction, and the activation of circulating leukocytes. Through these mechanisms, cigarette smoking elicits the aggregation and adhesion of leukocytes and/or platel…