Search results for "Cinnamates"
showing 3 items of 23 documents
Two new diterpenoids from kencur (Kaempferia galanga): Structure elucidation and chemosystematic significance
2021
Abstract Aromatic ginger or kencur (Kaempferia galanga L.) rhizomes are ground as a spice or pickled for consumption in south-east Asian cuisines; although widely used, until recently it has been less studied chemically than white and red ginger. Hydro-distillate extracts have identified several compounds that exhibit anticancer activity against select tumor cell lines in vitro, and most recently chemical analyses have focused on rhizome metabolites present in organic extracts. Here we report on two new diterpenoids including Δ8(14),15 polyhydroxlated isopimardienes, 1α-hydroperoxy-2α,6,7-trihydroxy-isopimara-6(7),8(14),15-triene (kaemgalangol E; 1) and 1α,7β-hydroxy-isopimara-8(14),15-dien…
Cyclecondensation of 3-amino-1,2,4-triazole with substituted methyl cinnamates
1999
The reaction of 3-amino-1,2,4-triazole (1) with substituted methyl cinnamates 2a-h leads selectively to the formation of 7-aryl-6,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-ones 3a-h. The structure eluci dation of the products is based on ir, 1H and 13C nmr measurements and X-ray diffraction.
N-Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis
2015
Seven N-cinnamoyltetraketides (1−7), including the new Ztoussaintine E (2), toussaintine F (6), and toussaintine G (7), were isolated from the methanol extract of the leaves of Toussaintia orientalis using column chromatography and HPLC. The configurations of E-toussaintine E (1) and toussaintines A (3) and D (5) are revised based on single-crystal X-ray diffraction data from racemic crystals. Both the crude methanol extract and the isolated constituents exhibit antimycobacterial activities (MIC 83.3−107.7 μM) against the H37Rv strain of Mycobacterium tuberculosis. Compounds 1, 3, 4, and 5 are cytotoxic (ED50 15.3−105.7 μM) against the MDA-MB-231 triple negative aggressive breast cancer cel…