Search results for "Clero"
showing 10 items of 2052 documents
Metals in Scalp Hair from Relapsing-Remitting Multiple Sclerosis Patients (RRMS)
2014
We measured the concentrations of 21 chemical elements (TE) in hair of 48 Sicilian patients with RRMS compared with 51 controls (HC). MS patients showed a significantly (p<0.01) lower hair concentration of Al and Rb and higher hair concentration of U compared to HC. The percentage of MS patients showing hair elemental concentrations greater than the 95th percentile of controls was 20% for Ni, 19% for Ba and U, and 15% for Ag, Mo and Se. The ratio Zn/Cu varied from 17 to 19, with no significant differences between HC and MS groups or between individuals differentiated by gender. No significant association was found between levels of each TE and age, disease duration, Expanded Disability Stat…
Cytotoxic neo-clerodane diterpenes from Stachys aegyptiaca
2018
Abstract Two new E/Z neo-clerodane diterpene isomers, trivially named stachaegyptin D (1) and E (2), together with known compounds, stachysolon monoacetate (3) and stachysolon diacetate (4), were isolated from an organic-solvent extract of the medicinal herb Stachys aegyptiaca. Structures were elucidated by a combination of spectroscopic methods, including HREIMS, 1H, 13C, DEPT, and 2D NMR analysis, as well as, first time X-ray analysis for stachysolone (3). All isolated metabolites showed some activity against the human hepatocellular cell line, HepG2. Compound 4 was the most active with an IC50 of 59.5 μM.
Trattamento riabilitativo della sclerodermia
2011
Estudio de marcadores de inflamación en ayuno y situación postprandial en la hipercolesterolemia primaria
2017
La aterosclerosis es el resultado de un proceso inflamatorio crónico de la pared arterial en cuya patogénesis intervienen numerosas células y mediadores histoquímicos que inician, perpetúan y complican la placa de ateroma. La inflamación está presente en todo el proceso aterosclerótico, iniciándose con la secreción de moléculas de adhesión y quimiotaxis leucocitarias en respuesta a diferentes estímulos. Por otra parte, la lipemia postprandial podría constituir un factor de riesgo para la enfermedad cardiovascular. Sus mecanismos aterogénicos podrían ser a través de efectos directos mediados por lipoproteínas o bien induciendo la secreción de citoquinas proinflamatorias relacionadas con el d…
Práctica 2. Valoración clínico-funcional en afecciones cardíacas
2011
La exploración clínico-funcional aporta las claves para el diagnóstico de las afecciones cardíacas. Si bien la Anamnesis es el procedimiento diagnóstico primario, se precisan exploraciones complementarias para realizar un correcto diagnóstico diferencial. En este sentido, son necesarios los tres elementos de la exploración física cardiovascular (inspección, palpación y auscultación) y pruebas complementarias como: el registro electrocardiográfico, la toma de la tensión arterial, la radiografía de tórax, el estudio ecocardiográfico, el cateterismo cardíaco, etc. L’exploració clínico-funcional aporta les claus per al diagnòstic de les afeccions cardíaques. A més de l’Anamnesi o procediment di…
Práctica 4. Exploración clínica arterial
2011
La exploración clínico-funcional aporta las claves para el diagnóstico de la patología vascular periférica. La Anamnesis detallada y la exploración física completa constituyen los pilares básicos en su detección. A esto se le deben sumar exploraciones complementarias que permitirán establecer el diagnóstico definitivo, así como la localización exacta de la lesión. L’exploració clínico-funcional aporta les claus per al diagnòstic de la patologia vascular perifèrica. L’Anamnesi detallada i l’exploració física completa constitueixen els pilars bàsics en la seua detecció. A més, cal afegir exploracions complementàries que perpetran establir el diagnòstic definitiu, així com la localització exac…
European evidence-based recommendations for clinical assessment of upper limb in neurorehabilitation (CAULIN): data synthesis from systematic reviews…
2021
Abstract Background Technology-supported rehabilitation can help alleviate the increasing need for cost-effective rehabilitation of neurological conditions, but use in clinical practice remains limited. Agreement on a core set of reliable, valid and accessible outcome measures to assess rehabilitation outcomes is needed to generate strong evidence about effectiveness of rehabilitation approaches, including technologies. This paper collates and synthesizes a core set from multiple sources; combining existing evidence, clinical practice guidelines and expert consensus into European recommendations for Clinical Assessment of Upper Limb In Neurorehabilitation (CAULIN). Methods Data from systema…
Enzymatically modified, nonoxidized LDL induces selective adhesion and transmigration of monocytes and T-lymphocytes through human endothelial cell m…
1999
Abstract —Circulating monocytes and T lymphocytes extravasate through the endothelium at sites of developing atheromatous lesions, where they tend to accumulate and mediate the progression of the disease. We have previously demonstrated the presence of an enzymatically degraded, nonoxidized form of LDL (E-LDL) in early human fatty streaks, which possesses major biological properties of an atherogenic lipoprotein. The effects of E-LDL on human endothelial cells have now been studied with respect to adhesion and transmigration of monocytes and T lymphocytes. E-LDL induced a rapid and dose-dependent selective adhesion of monocytes and T lymphocytes to endothelial cell monolayers within 30 min…
Polymorphonuclear leukocyte membrane fluidity and cytosolic Ca2+ concentration in subjects with vascular atherosclerotic disease subdivided according…
2006
An abnormal activation state of polymorphonuclear leukocytes (PMN) plays a key role in organ injury induced by vascular atherosclerotic disease (VAD) and diabetes mellitus (DM). PMN membrane fluidity and cytosolic Ca2+ content can be considered markers of PMN activation. In this research we evaluated the PMN membrane fluidity and cytosolic Ca2+ content in VAD subjects with and without type 2 DM and examined the association between these parameters and the mono- or polyvascular localization. We enrolled 155 VAD subjects, including 92 non-diabetic (group A: mean age 63.6 +/- 9.2 years) and 63 diabetic patients (group B: mean age 65.4 +/- 7.8 years). Among group A 63 patients had monovascular …
Chapter 13 Antiphospholipid Antibodies and Vasculitis
2009
Abstract Besides the large group of primary vasculitis diseases, vasculitis in autoimmune diseases is most commonly associated with systemic lupus erythematosus (SLE), scleroderma, rheumatoid arthritis, insulin-dependent diabetes mellitus, and dermatomyositis. The antiphospholipid syndrome (APS), as a relatively recently recognized autoimmune disorder, may also present with a variety of vasculitis features. These non-typical vasculitis syndromes have to be considered very carefully in the APS, and vasculitis manifestations presenting as systemic involvement in APS patients have to be identified very early to prevent patients from rapidly developing organ damage. The aim of this review artic…