Search results for "Clos"

The closure of Nastola care home: A longitudinal study on deinstitutionalisation

2009

The Nastola Care Home, an institution housing 95 people with intellectual disability, was closed in 1989, with residents moving out into small community group homes of five people each. An intensive process of reorganization, including unitisation and staff training, occurred within the institution before its closure. The adaptive behaviour of 66 residents was measured a total of seven times, with the first phase beginning two and half years before the move, and the second phase extending to two years after the move. The results indicated an increase in adaptive skills of the residents in both phases. Challenging behaviour of the residents decreased before the move, but not afterwards. Comm…

2015

Since the percentage of single adults is steadily increasing, the reasons for this development have become a matter of growing interest. Hereby, an individual’s attachment style has come under close scrutiny in the context of its possible association to the partnership status. In the current study, a comparison of an individual’s attachment style, gender, age, education, and income was carried out in regard to the partnership status. Furthermore, an analysis of variance was computed to compare the attachment style within different groups. A sample of 1,676 representative participants between 18 and 60 years was investigated (M = 41.0, SD = 12.3); 54% were female, and 40% were single. Attach…

The Role of Education in Self–Employment Success in Finland

2002

This paper analyzes the effect of self–employed persons’ education on the success of their firms during the economic downturn and upturn of the 1990's. It is found that the business cycle affects the relative closure rates of firms run by self–employed with any level of education. Exit probability is lower for the highly educated during bust, but higher in boom. This is accounted for by two facts. First, running a small firm is argued to be a less attractive choice to wage work, particularly for the highly educated, due to lower earning prospects, less stable stream of earnings, and the cultural tradition of working in large corporations. Second, the highly educated faced a higher outside d…

Genetic rearrangements in the pathogenicity locus of Clostridium difficile strain 8864 – implications for transcription, expression and enzymatic act…

1998

The pathogenicity locus (PaLoc) of Clostridium difficile isolate 8864 was investigated to locate genetic rearrangements that would explain the exceptional pathogenicity of this particular isolate. Two major changes were defined: an insertion of 1.1 kb between the two genes tcdA and tcdE, coding for the enterotoxin and an accessory protein of unknown function, respectively, and a deletion of 5.9 kb encompassing the 3' ends of tcdA and tcdC. Transcription of the tcdA-E genes is severely affected by both rearrangements, explaining the demonstrated complete lack of TcdA polypeptide. We present a model of coordinate, growth-related transcription of the tcdA-E genes that confirms our previous fin…

The second component of human complement: Use of glycosidases and glucosylation to distinguish the two forms

1988

Abstract The two forms of human plasma C2 that were described in the preceding report (1) were investigated for their functional and biochemical differences. Incubation with the neuraminidase (NAN'dase) of Clostridium perfringens at 37°C resulted in a four- to fivefold increase in the hemolytic activity of both forms. The increase in activity was different than the increase caused by treatment with iodine. The mechanism of increased activity of NAN'dase-treated C2 was the generation of increased molecules of activated C3 (C3b), resulting in more molecules of C5 binding to (C4b, 2a, 3b)n. Removal of N-acetyl-neuraminate from C2 did not alter its binding to a cationic exchanger. Nonenzymatic …

A novel cytotoxin from Clostridium difficile serogroup F is a functional hybrid between two other large clostridial cytotoxins.

1999

Abstract The large clostridial cytotoxins (LCTs) constitute a group of high molecular weight clostridial cytotoxins that inactivate cellular small GTP-binding proteins. We demonstrate that a novel LCT (TcdB-1470) from Clostridium difficile strain 1470 is a functional hybrid between “reference” TcdB-10463 andClostridium sordellii TcsL-1522. It bound to the same specific receptor as TcdB-10463 but glucosylated the same GTP-binding proteins as TcsL-1522. All three toxins had equal enzymatic potencies but were equally cytotoxic only when microinjected. When applied extracellularly TcdB-1470 and TcdB-10463 were considerably more potent cytotoxins than TcsL-1522. The small GTP-binding protein R-R…

Analysis of good corporate governance at Indonesian telecom industry after privatization: case study at PT Telekom an PT Indosat

2006

Masteroppgave i økonomi og administrasjon, Høgskolen i Agder, Kristiansand The objective of this research is to examine whether there are differences of implementation of good corporate governance of company which privatized using different methods. This is relevant with the change of privatization pattern conducted by the government of Indonesia toward its state-owned companies, from Public Offering to Strategic Sale. One of important decisions taken by the government after the economic crisis is privatization of state-owned companies. It is done because the government finds difficulties to financing its national development programs and economic recovery. From company side, the change of …

Fatigue crack propagation from a cold-worked hole

2007

Abstract The cold expansion process is widely used to enhance the fatigue life of structures with fastener holes. Various studies assert that the cold expansion improves the fatigue strength of fastener holes; however, the improvement of fatigue life is difficult to quantify. Therefore, the influence on fatigue life of cold-worked process was studied by numerical and experimental tests. Then, a parametric study on material hardening behavior and Bauschinger’s parameter was performed for several loading conditions in order to determine their effect on crack growth propagation. The results of the numerical tests have exhibited a good prediction of the fatigue life of the component.

Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejection.

1991

Leflunomide has been shown to be very effective in preventing and curing several autoimmune animal diseases. Further, this agent is as effective as cyclosporin A in preventing the rejection of skin and kidney transplants in rats. Preliminary results from patients suffering from severe cases of rheumatoid arthritis demonstrated that clinical and immunological parameters could be improved with leflunomide therapy. Mode of action studies revealed that this substance antagonizes the proliferation inducing activity of several cytokines and is cytostatic for certain cell types. In this light, we could show that tyrosine phosphorylation of the RR-SRC peptide substrate and the autophosphorylation o…

A NONHEALING ULCER DIAGNOSED AS EXTRAMEDULLARY PLASMOCYTOMA OF THE LIMB EIGHT YEARS AFTER CARDIAC TRANSPLANTATION

1999

A 63-year-old man was hospitalized for a nonhealing ulcer of the left lower leg that appeared 8 years after orthotopic cardiac transplantation under immunosuppressive therapy including cyclosporine. Serum protein electrophoresis, immunofixation, and urinalysis revealed a monoclonal gammopathy IgG kappa. The final diagnosis of an extramedullary plasmocytoma was made by biopsy of the ulcer, which showed formations of plasmablastic cells. We report a rare case of extramedullary plasmocytoma as a posttransplantational malignancy.