Search results for "Cni"
showing 10 items of 3680 documents
Messing Up the Cancer Stem Cell Chemoresistance Mechanisms Supported by Tumor Microenvironment
2021
Despite the recent advances in cancer patient management and in the development of targeted therapies, systemic chemotherapy is currently used as a first-line treatment for many cancer types. After an initial partial response, patients become refractory to standard therapy fostering rapid tumor progression. Compelling evidence highlights that the resistance to chemotherapeutic regimens is a peculiarity of a subpopulation of cancer cells within tumor mass, known as cancer stem cells (CSCs). This cellular compartment is endowed with tumor-initiating and metastasis formation capabilities. CSC chemoresistance is sustained by a plethora of grow factors and cytokines released by neighboring tumor…
Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevance.
2016
Cancer stem cells (CSCs) have been identified in several solid malignancies and are now emerging as a plausible target for drug discovery. Beside the questionable existence of CSCs specific markers, the expression of CD133 was reported to be responsible for conferring CSC aggressiveness. Here, we identified two G-rich sequences localized within the introns 3 and 7 of the CD133 gene able to form G-quadruplex (G4) structures, bound and stabilized by small molecules. We further showed that treatment of patient-derived colon CSCs with G4-interacting agents triggers alternative splicing that dramatically impairs the expression of CD133. Interestingly, this is strongly associated with a loss of C…
Metabolic Escape Routes of Cancer Stem Cells and Therapeutic Opportunities
2020
Although improvement in early diagnosis and treatment ameliorated life expectancy of cancer patients, metastatic disease still lacks effective therapeutic approaches. Resistance to anticancer therapies stems from the refractoriness of a subpopulation of cancer cells—termed cancer stem cells (CSCs)—which is endowed with tumor initiation and metastasis formation potential. CSCs are heterogeneous and diverge by phenotypic, functional and metabolic perspectives. Intrinsic as well as extrinsic stimuli dictated by the tumor microenvironment (TME)have critical roles in determining cell metabolic reprogramming from glycolytic toward an oxidative phenotype and vice versa, allowing cancer cells to th…
Dual Inhibition of Myc Transcription and PI3K Activity Effectively Targets Colorectal Cancer Stem Cells
2022
Despite advances in the curative approach, the survival rate of advanced colorectal cancer (CRC) patients is still poor, which is likely due to the emergence of cancer cell clones resistant to the available therapeutic options. We have already shown that CD44v6-positive CRC stem cells (CR-CSCs) are refractory toward standard anti-tumor therapeutic agents due to the activation of the PI3K pathway together with high HER2 expression levels. Tumor microenvironmental cytokines confer resistance to CR-CSCs against HER2/PI3K targeting by enhancing activation of the MAPK pathway. Here, we show that the CSC compartment, spared by BRAF inhibitor-based targeted therapy, is associated with increased ex…
Dissecting the Mechanism of Action of Spiperone—A Candidate for Drug Repurposing for Colorectal Cancer
2022
Approximately 50% of colorectal cancer (CRC) patients still die from recurrence and metastatic disease, highlighting the need for novel therapeutic strategies. Drug repurposing is attracting increasing attention because, compared to traditional de novo drug discovery processes, it may reduce drug development periods and costs. Epidemiological and preclinical evidence support the antitumor activity of antipsychotic drugs. Herein, we dissect the mechanism of action of the typical antipsychotic spiperone in CRC. Spiperone can reduce the clonogenic potential of stem-like CRC cells (CRC-SCs) and induce cell cycle arrest and apoptosis, in both differentiated and CRC-SCs, at clinically relevant co…
Targeting of the Peritumoral Adipose Tissue Microenvironment as an Innovative Antitumor Therapeutic Strategy
2022
The tumor microenvironment (TME) plays a key role in promoting and sustaining cancer growth. Adipose tissue (AT), due to its anatomical distribution, is a prevalent component of TME, and contributes to cancer development and progression. Cancer-associated adipocytes (CAAs), reprogrammed by cancer stem cells (CSCs), drive cancer progression by releasing metabolites and inflammatory adipokines. In this review, we highlight the mechanisms underlying the bidirectional crosstalk among CAAs, CSCs, and stromal cells. Moreover, we focus on the recent advances in the therapeutic targeting of adipocyte-released factors as an innovative strategy to counteract cancer progression.
Le proprietà nutrizionali e salutistiche del formaggio in funzione della stagione di pascolamento
2022
Il consumo alimentare si è notevolmente modificato negli ultimi anni. L’alimento, oltre a rappresentare una fonte di nutrienti, è diventato anche espressione dello stile di vita ed un mezzo di interazione e distinzione tra le persone. Il consumatore moderno, in risposta ai modelli alimentari che nei paesi industrializzati hanno generato gravi problemi di salute (obesità, malattie cardiovascolari, tumori), tende ad essere più informato, critico ed esigente sotto il profilo salutistico. Inoltre, cresce nel consumatore l'interesse per il cibo sostenibile proveniente da sistemi che, contribuendo alla mitigazione delle emissioni di CO2 e limitando lo sfruttamento delle risorse naturali, producon…
Energy and environmental impacts of energy related products: the case study of a device for reducing natural gas consumption in the production of san…
2015
The European Commission identified the Energy related Products (ErP) as products that account for a large share of the European energy and natural resources consumption. In order to reduce the energy and environmental impacts of ErP, the European Commission published the Directive 2009/125/EC, which establishes a framework for setting the eco-design requirements for these products. The above Directive represents a key component of the European policy for improving the energy and environmental performance of products on the market. In this context, it is of paramount importance to develop scientific researches aimed to assess the energy and environmental performances of the current products …
The use of energy in the Mediterranean fishing catching sector. A Sicilian perspective
2010
This article address an issue of paramount importance in the Mediterranean area, that is the efficient use of energy and sustainability of fishing sector. A recent study concerning the situation of Fishery and Aquaculture in Sicily highlighted that the Sicilian fishing system requires a bigger amount of energy than the typical Italian or European situation, in order of getting the product available to the market. On the other hand this involves an higher level of environmental pollution, for a given quantity of catch. One of the main findings is that there is a need for a clear, scientifically-founded panorama of the situation and that further studies should be undertaken to provide fishing…
L'analogia physis-techne in Aristotele (Fisica B, 3-9) e la teoria interventistica della causalità
2015
Ho diviso la lettura dei capitoli 3-9 del libro B della Fisica di Aristotele in due momenti: nei capitoli 3-7 viene data la definizione delle quattro cause e si pone il problema se caso e fortuna sono cause del divenire, nei capitoli 8-9 si risolve tale aporia in senso teleologico e si traggono le conclusioni sulla relazione physis-techne. La concezione interventistica della causalità sostiene che c’è uno stretto legame fra causalità e intervento umano in natura: l’idea di una relazione causale fra due eventi (uno che causa e l’altro che è causato) ha come presupposto il concetto di azione intenzionale e nasce dalla riflessione dell’uomo sul proprio operare finalizzato nella realtà. Sebbene…