Search results for "Combined"
showing 10 items of 1205 documents
SAHA/TRAIL combination induces detachment and anoikis of MDA-MB231 and MCF-7 breast cancer cells
2012
Abstract SAHA, an inhibitor of histone deacetylase activity, has been shown to sensitize tumor cells to apoptosis induced by TRAIL, a member of TNF-family. In this paper we investigated the effect of SAHA/TRAIL combination in two breast cancer cell lines, the ERα−positive MCF-7 and the ERα−negative MDA-MB231. Treatment of MDA-MB231 and MCF-7 cells with SAHA in combination with TRAIL caused detachment of cells followed by anoikis, a form of apoptosis which occurs after cell detachment, while treatment with SAHA or TRAIL alone did not produce these effects. The effects were more evident in MDA-MB231 cells, which were chosen for ascertaining the mechanism of SAHA/TRAIL action. Our results show…
The actual management of colorectal liver metastases
2020
Colorectal cancer is one of the most frequent cancers in the world and between 50% and 60% of patients will develop colorectal liver metastases (CRLM) during the disease. There have been great improvements in the management of CRLM during the last decades. The combination of modern chemotherapeutic and biological systemic treatments with aggressive surgical resection strategies is currently the base for the treatment of patients considered unresectable until few years ago. Furthermore, several new treatments for the local control of CRLM have been developed and are now part of the arsenal of multidisciplinary teams for the treatment of these complex patients. The aim of this review was to s…
Two Treatments for Fear of Flying Compared: Cognitive Behavioral Therapy Combined with Systematic Desensitization or Eye Movement Desensitization and…
2011
This study aimed to test a combined treatment with eye movement desensitization and reprocessing (EMDR) and cognitive behavioral therapy (CBT), compared with CBT integrated with systematic desensitization, in reducing fear of flying. Participants were patients with aerophobia, who were randomly assigned to two experimental groups in a before- and after-treatment research design. The Flight Anxiety Situations Questionnaire (FAS) and the Flight Anxiety Modality Questionnaire (FAM) were used. The efficacy of each program was evaluated comparing the pre- and post-treatment levels of fear of flying within subjects. A comparison of the post-treatment scores between subjects was also conducted. R…
Risk stratification for invasive fungal infections in patients with hematological malignancies: SEIFEM recommendations
2016
Invasive fungal infections (IFIs) are an important cause of morbidity and mortality in immunocompromised patients. Patients with hematological malignancies undergoing conventional chemotherapy, autologous or allogeneic hematopoietic stem cell transplantation are considered at high risk, and Aspergillus spp. represents the most frequently isolated micro-organisms. In the last years, attention has also been focused on other rare molds (e.g., Zygomycetes, Fusarium spp.) responsible for devastating clinical manifestations. The extensive use of antifungal prophylaxis has reduced the infections from yeasts (e.g., candidemia) even though they are still associated with high mortality rates. This pa…
Infections caused by Pseudomonas aeruginosa: relatively frequent isolation of serogroup 12 from clinical specimens.
1985
Serological typing of P. aeruginosa is the most simple and reliable procedure recommended for ≪ in-house ≫ investigations and for studies of suspected outbreaks of infection by this microorganism. It is also a useful procedure in order to know serotype prevalence in a definite geografical area and to obtain indications about the more appropriate composition of polivalent anti-Pseudomonas vaccines. In the present report, we describe the relatively high frequency of isolation of serogroup 12 from patients in Palermo, Italy. Serogroup 12 is very rare in north-Europe and in the USA, and, as a consequence, it is not included in some vaccine preparations. In Palermo, strains belonging to this ser…
MULTIPLE SCLEROSIS: PHYSICAL ACTIVITY AND WELL-BEING
2017
Multiple sclerosis (MS) is a chronic disease that affects central nervous system (CNS) – coexists in brain, spinal cord and optic nerves. It can process in three different courses: remitting, progressive and progressive-relapsing. Although there is still no cure for MS, effective strategies are available to modify the disease course, reduce number of relapses, rate of progressions and development of new lesions. Nowadays, moderate physical performance is strongly recommended: besides having positive effects on the body, it can have a positive effect on the psychophysical wellbeing. Essentially there are 3 types of training protocols: aerobic (endurance training), strength training (resistan…
A CCHP system fed by low enthalpy sources in Mediterranean area
2018
Climate change and energy consumption increasingly call for a better use of energy sources. Renewable sources are still growing in the power production of many countries, so leading to the reduction of CO2 emissions. Further restrictions will be applied to the use of fossil fuels with a lot of consequences; for example, some German cities are all contemplating bans related to diesel pollution, and on the other hand some of the biggest car producers are planning to stop the diesel engines production in a few years. At the same time, some restrictions are applied also to many refrigerating fluids, in order of limiting the ODP and GWP values. This restriction leads to research new fluids and/o…
A CCHP system fed by low enthalpy sources in Mediterranean area
2018
Climate change and energy consumption increasingly call for a better use of energy sources. Renewable sources are still growing in the power production of many countries, so leading to the reduction of CO2 emissions. Further restrictions will be applied to the use of fossil fuels with a lot of consequences; for example, major German cities such as Stuttgart, Dusseldorf and Hamburg are all contemplating bans related to diesel pollution, and on the other hand some of the biggest car producers - FCA, Toyota, etc. - are planning to stop the diesel engines production in a few years. At the same time, some restrictions are applied also to many refrigerating fluids, in order of firstly limiting th…
Influence of the distance between rivets in self-piercing riveting bonded joints made of carbon fiber panels and AA2024 blanks
2012
Abstract The increasing use of new materials alternative to steel in manufacturing industry has led to a greater emphasis on the improvement and the development of specific joining approaches allowing to get effective mechanical properties even when different materials are joined together. It should be observed that often the traditional welding techniques show several limitations as aluminum or magnesium alloys are used, and, what is more, they are not compatible with composite materials. The development of structures made of these materials has renewed the use of mechanical fastening operations. The present paper investigates the influence of the distance between rivets in self-piercing r…
An Embedded System for the integration of a Combined Photovoltaic Solar (CPS) system into a ZigBee Home Area Network
2011
In this paper is reported the design and implementation of an electronic system capable of communicating over a standard ZigBee network in order to let a residential gateway collector, named agent, gain access to the parameters of a Combined Photovoltaic and Solar thermal (CPS) plant, thus realizing a networked energy production appliance . The system is made of three parts: a PV metering device, a boiler metering device also capable of controlling a heating resistor embedded within the boiler tank, and a data collector acting as a ZigBee node. The data collector device periodically retrieves the following parameters from the metering devices: instantaneous photovoltaic power production, ac…