Search results for "Complex."
showing 10 items of 5824 documents
Multilayered cultural identity and the perception of the self
2012
This qualitative study examines the reciprocal relationship between a person’s multilayered cultural identity (MCI) and the concept of self (CoS), that is presented purely on a theoretical level and encompasses various theories. Nowadays, in an increasingly globalising world, it is not enough to merely look at a national, ethnic or other type of identity. It is important to realise that there are different layers in an identity that one can view themselves through. The ways an individual perceives themselves through their multicultural background can also be different. This thesis helps identify the ways a person can see themselves. The thesis also attempts to explain the varied nature of o…
The Complex System Theory for the Analysis of Inter-Firm Networks: A Literature Overview and Theoretic Framework
2011
In this paper we discuss the body of knowledge known as complex system theory and its relevance to the analysis of inter-firm networks. We start by addressing the development of systems thinking. Through a literature overview, we point out the main elements for the development of systemic thought from its beginning, through its application in business sciences, to the birth of Complex Systems Theory (CST). With these initial annotations we provide an introduction to the concepts of the complex systems theory. We will underscore those aspects of CST that can be useful to analyze inter-firm networks, in order to highlight the evolutionary dynamics of the networks and to clarify the logical li…
Tucupentol, a novel mono-tetrahydrofuranic acetogenin from Annona montana, as a potent inhibitor of mitochondrial complex I.
2009
Ten acetogenins, one of them new, were isolated from leaves and twigs of a Bolivian collection of Annona montana. The new compound that we named tucupentol (1) is a mono-tetrahydrofuranpentahydroxy-acetogenin. The inhibitory potency of tucupentol (1) on the mitochondrial complex I was evaluated, and this activity was compared with that of the known acetogenins, annonacin-A, cisannonacin-10-one, aromin, and gigantetronenin, also isolated from this plant material. The mentioned acetogenins acted as selective inhibitors of mitochondrial complex I in the 0.8-5.4-nM range. Fil: Álvarez Colom, Olga. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química …
Precīzie kvantu algoritmi, izmantojot 1-kvantu-vaicājuma izsaukumus
2018
Darbā ir analizēti zināmi unikāli precīzie kvantu algoritmi, kuru īpašības ir atšķirīgas no citiem literatūrā atrodamiem algoritmiem, un uzsākts pētīt iespējas vispārināt šajos algoritmos esošos paņēmienus. Darbā ir noformulēts jauns skaitļošanas modelis, kas ir saistīts ar precīzo kvantu vaicājumu modeli. Veikti skaitliski aprēķini, lai palīdzētu saprast jaunā modeļa iespējas un ierobežojumus. Izteiktas hipotēzes un virzieni, kādos turpināt analīzi un pētījumu.
Comparative study of a whole-cell pertussis vaccine and a recombinant acellular pertussis vaccine.
1994
The safety and immunogenicity of an acellular pertussis vaccine containing the genetically detoxified pertussis toxin PT-9K/129C, filamentous hemagglutinin, and pertactin, together with diphtheria and tetanus toxoids, were compared with those of a whole-cell pertussis component-diphtheria-tetanus vaccine. Four hundred eighty infants were enrolled into this prospective, multicenter, double-blind study. Each infant was randomly given three doses of one of the two vaccines at 2, 4, and 6 months of age. Both local and systemic adverse reactions, reported within 48 hours and 7 days of each injection, were less frequent after the acellular vaccine than after the whole-cell vaccine. The enzyme-lin…
Development of peptidomimetic boronates as proteasome inhibitors.
2013
Abstract Proteasome inhibition has emerged over the past decade as an effective therapeutic approach for the treatment of hematologic malignancies. It is a multicatalytic complex, whose proteolytic activity relies in three types of subunits: chymotrypsin-like (β5), trypsin-like (β2) and caspase-like (β1). Most important for the development of effective antitumor agents is the inhibition of the β5 subunits. In this context, the dipeptide boronate bortezomib (Velcade ® ) represents the first proteasome inhibitor approved by the FDA and the lead compound in drug discovery. This paper describes the synthesis and biological evaluation of a series of conformationally constrained pseudopeptide bor…
First bodipy–DOTA derivatives as probes for bimodal imaging
2010
The synthesis and the photophysical studies of the first bodipy-DOTA and its In(III), Ga(III) and Cu(II) complexes are reported. The introduction of an isothiocyanate handle generates a new bimodal imaging agent capable of both optical and nuclear imaging.
Chromo-fluorogenic BODIPY-complexes for selective detection of V-type nerve agent surrogates
2014
Two new Eu3+ and Au3+ BODIPY-complexes capable of chromofluorogenically detecting micromolar concentrations of V-type nerve agent surrogates by a simple displacement assay are described
Near-infrared emitting fluorescent homobimetallic gold(I) complexes displaying promising in vitro and in vivo therapeutic properties
2021
International audience; Boron neutron capture therapy (BNCT) has the potential to specifically destroy tumor cells without damaging the tissues infiltrated by the tumor. BNCT is a binary treatment method based on the combination of two agents that have no effect when applied individually: 10B and thermal neutrons. Exclusively, the combination of both produces an effect, whose extent depends on the amount of 10B in the tumor but also on the organs at risk. It is not yet possible to determine the 10B concentration in a specific tissue using non-invasive methods. At present, it is only possible to measure the 10B concentration in blood and to estimate the boron concentration in tissues based o…
BODIPY-phosphane as a versatile tool for easy access to new metal-based theranostics
2012
A new BODIPY-phosphane was synthesized and proved to be a versatile tool for imaging organometallic complexes. It also led to easy access to a new family of theranostics, featuring gold, ruthenium and osmium complexes. The compounds' cytotoxicity was tested on cancer cells, and their cell uptake was followed by fluorescence microscopy in vitro.