Search results for "Compromis"
showing 10 items of 397 documents
Growth and Osteogenic Differentiation of Discarded Gingiva-Derived Mesenchymal Stem Cells on a Commercial Scaffold
2020
Background In periodontal patients with jawbone resorption, the autologous bone graft is considered a "gold standard" procedure for the placing of dental prosthesis; however, this procedure is a costly intervention and poses the risk of clinical complications. Thanks to the use of adult mesenchymal stem cells, smart biomaterials, and active biomolecules, regenerative medicine and bone tissue engineering represent a valid alternative to the traditional procedures. Aims In the past, mesenchymal stem cells isolated from periodontally compromised gingiva were considered a biological waste and discarded during surgical procedures. This study aims to test the osteoconductive activity of FISIOGRAF…
Milker's nodule: an occupational infection and threat to the immunocompromised
2017
Milker's nodule virus, also called paravaccinia virus is a DNA virus of the parapoxvirus genus transmitted from infected cows to humans. It results from contact with cattle, cattle byproducts, or fomites. Classified as an occupational disorder, those at risk of exposure include farmers, butchers, and agricultural tourists. The viral infection begins 5-15 days after inoculation as an erythematous-purple, round nodule with a clear depressed center, and a surrounding erythematous ring. While familiar to those in farming communities, the presence of the nodule may be concerning to others, particularly the immunosuppressed. Milker's nodules are self-limited in immunocompetent individuals and hea…
Mouse models of multiple myeloma: technologic platforms and perspectives.
2018
Murine models of human multiple myeloma (MM) are key tools for the study of disease biology as well as for investigation and selection of novel candidate therapeutics for clinical translation. In the last years, a variety of pre-clinical models have been generated to recapitulate a wide spectrum of biological features of MM. These systems range from spontaneous or transgenic models of murine MM, to subcutaneous or orthothopic xenografts of human MM cell lines in immune compromised animals, to platform allowing the engraftment of primary/bone marrow-dependent MM cells within a human bone marrow milieu to fully recapitulate human disease. Selecting the right model for specific pre-clinical re…
Cytomegalovirus infection management in solid organ transplant recipients across European centers in the time of molecular diagnostics: An ESGICH sur…
2017
Background Scant information is available about how transplant centers are managing their use of quantitative molecular testing (QNAT) assays for active cytomegalovirus (CMV) infection monitoring in solid organ transplant (SOT) recipients. The current study was aimed at gathering information on current practices in the management of CMV infection across European centers in the era of molecular testing assays. Methods A questionnaire-based cross-sectional survey study was conducted by the European Study Group of Infections in Immunocompromised Hosts (ESGICH) of the Society of Clinical Microbiology and Infectious Diseases (ESCMID). The invitation and a weekly reminder with a personal link to …
Association between obesity and periodontal disease. A systematic review of epidemiological studies and controlled clinical trials.
2016
Background: Obesity is a very prevalent chronic disease worldwide and has been suggested to increase susceptibility of periodontitis. The aim of this paper was to provide a systematic review of the association between obesity and periodontal disease, and to determine the possible mechanisms underlying in this relationship. Material and Methods: A literature search was carried out in the databases PubMed-Medline and Embase. Controlled clinical trials and observational studies identifying periodontal and body composition parameters were selected. Each article was subjected to data extraction and quality assessment. Results: A total of 284 articles were identified, of which 64 were preselected…
¿Atenuación del compromiso del hablante?: el caso de los evidenciales "por lo visto" y "se ve que"
2018
espanolBuena parte de la bibliografia sobre marcadores evidenciales en espanol senala la atenuacion del compromiso (o responsabilidad) de lo dicho como uno de sus rasgos definitorios. Sin embargo, tanto la nocion de atenuacion como la de compromiso del hablante se han empleado con distintas acepciones, segun los trabajos. En primer lugar, se revisan estas acepciones y se propone, siguiendo a Cornillie/Delbecque, distinguir las nociones compromiso del hablante de implicacion del hablante, las cuales funcionan de manera inversa en algunos usos evidenciales: (i) de las evidencias reportativas a las inferenciales conjeturales hay una escala de menos a mas implicacion del hablante; (ii) en las e…
Preclinical models in oncological pharmacology: limits and advantages
2021
A wide range of experimental tumor models, each with distinct advantages and disadvantages, is nowadays available. Due to the inherent differences in their complexity and functionality, the choice of the model is usually dependent on the application. Thus, to advance specific knowledge, one has to choose and use appropriate models, which complexity is largely dependent on the hypotheses to test, that is on the objectives. Whatever the model chosen, the complexity of cancer is such that none of them will be able to fully represent it. In vitro tumor models have provided important tools for cancer research and still serve as low-cost screening platforms for drugs. The improved understanding o…
Splenic Littoral Cell Hemangioendothelioma in a Patient With Crohn's Disease Previously Treated With Immunomodulators and Anti-TNF Agents: A Rare Tum…
2011
Th e risk of malignancy in Crohn ’ s disease (CD) has been well described. Moreover, immunomodulators, uch as azathioprine (AZA) and 6-mercaptopurine (6-MP), and biological agents, such as infl iximab and adalimumab, may promote carcinogenesis ( 1 – 3 ). Splenic littoral cell tumors are recently described tumors of vascular origin composed of endothelial cells, with typical microscopic and immunohistochemical features of splenic sinus lining cells ( 4 ). Clinical findings are not specific, and outcome is unpredictable but usually benign, although a few cases with a malignant behavior have been reported ( 5,6 ). We report a 58-year-old Caucasian man with a long history of ileocolonic CD.
El rol de la cultura organizativa en la relación entre las prácticas de alto rendimiento y el compromiso afectivo
2019
Durante años el comportamiento y las actitudes de los individuos han sido el foco de análisis en la disciplina de dirección de empresas. Los hallazgos en las investigaciones han demostrado el fuerte vínculo de las denominadas prácticas de alto rendimiento con actitudes como el compromiso afectivo de los individuos hacia la organización. A pesar de que el compromiso fue incialmente analizado como un constructo unidimensional, son muchos los autores que han identificado que el compromiso está compuesto por varias dimensiones como el compromiso normativo, el compromiso de continuidad y el compromiso afectivo. Este último ha sido catalogado como el indicador real de compromiso organizativo, deb…
Profili applicativi della clausola compromissoria in ambito sportivo. Studio di diritto domestico e comparato.
2021
Lo studio della clausola compromissoria conduce gli interpreti ad esplorare uno dei settori più intriganti nei quali l?autonomia privata può spingersi a lambire i confini ordinamentali. Il sistema di giustizia sportiva rappresenta un interessante banco di prova e di confronto, alla luce delle sue peculiarità e specificità. L?esperienza comparatistica e la più attenta riflessione ermeneutica degli ultimi anni suggeriscono un drastico ripensamento delle categorie ordinanti a livello dogmatico, tradizionalmente applicate in materia arbitrale, così da aprire nuovi e inesplorati orizzonti all?operatività delle ADR nell?ordito domestico.