Search results for "Compromise"
showing 10 items of 220 documents
Enhancerless Cytomegalovirus Is Capable of Establishing a Low-Level Maintenance Infection in Severely Immunodeficient Host Tissues but Fails in Expon…
2010
ABSTRACT Major immediate-early transcriptional enhancers are genetic control elements that act, through docking with host transcription factors, as a decisive regulatory unit for efficient initiation of the productive virus cycle. Animal models are required for studying the function of enhancers paradigmatically in host organs. Here, we have sought to quantitatively assess the establishment, maintenance, and level of in vivo growth of enhancerless mutants of murine cytomegalovirus in comparison with those of an enhancer-bearing counterpart in models of the immunocompromised or immunologically immature host. Evidence is presented showing that enhancerless viruses are capable of forming restr…
Frings, Theodor (1886–1968)
2006
Theodor Frings, late professor of German language and literature at the university of Leipzig, dealt with the dynamics of language in history, with the contact of German with neighbouring languages, such as, Dutch, Romance (“Germania Romana”) and Slavic languages. To Frings, the explanation of language change was the ‘external’ history. His description of the regional basis of Standard German, namely, the compromise language caused by dialect mixture in east Germany, was well accepted.
Fatigue assessment questionnaire: standardization of a cancer-specific instrument based on the general population.
2005
<i>Objectives:</i> Fatigue has become a major issue of concern in the care of cancer patients, as it has been shown to compromise their quality of life in a significant and lasting way. However, there is a lack of economic and specific measures. The Fatigue Assessment Questionnaire (FAQ) has been developed based on thorough interviews and tested on a large mixed sample of cancer patients. The purposes of this paper are to test the psychometric properties of the FAQ and to provide norms for the German population. <i>Methods:</i> The FAQ was administered to a representative sample of the German population (1,340 female and 1,101 male participants) along with standardiz…
Prophylaxis and treatment of hepatitis B in immunocompromised patients.
2007
The literature on hepatitis B virus (HBV) in immunocompromised patients is heterogeneous and referred mainly to the pre-antivirals era. Today a rational approach to the problem of hepatitis B in these patients provides for: (a) the evaluation of HBV markers and of liver condition in all subjects starting immunosuppressive therapies (baseline), (b) the treatment with antivirals (therapy) of active carriers, (c) the pre-emptive use of antivirals (prophylaxis) in inactive carriers, especially if they are undergoing immunosuppressive therapies judged to be at high risk, (d) the biochemical and hepatitis B surface antigen (HBsAg) monitoring (or universal prophylaxis, in case of high risk immunos…
Knowledge of bisphosphonate-related osteonecrosis of the Jawsamong Mexican dentists
2017
Background Bisphosphonate-related osteonecrosis is an infrequent but potentially serious complication. Its treatment remains complex, and in some cases can be mutilating. Prevention, a correct diagnosis and opportune management are crucial. Material and Methods A cross-sectional study was made, interviewing 410 dentists with the aim of assessing their knowledge of the subject. Results Practically all of the dental professionals (99.7%) were found to lack sufficient knowledge of the prevention, diagnosis and management of bisphosphonate-related osteonecrosis. Conclusions Actions including increased diffusion in the professional media and inclusion of the subject in training programs are need…
Making Bishops in the Malta of the Knights, 1530-1798
2015
During the early modern age the appointment of Maltese bishops involved conflicts in the management of ecclesiastical patronage, jurisdictional issues and international diplomacy. The procedure for appointment, established by Charles v in 1530 when he granted Malta to the Order of St John, was the result of a compromise: safeguarding rights of royal patronage without undermining the independence of an international military order. It is important, however, to underline the reforming activity conducted by bishops appointed in such political ways, especially through the application of some institutions provided by the Council of Trent, such as diocesan synods.
Dante en la cultura Catalana a l'entorn del casal de Barcelona (1381-1410/12)
2016
This article analyzes in a historical context the earliest evidences of Dante’s influence on Catalan culture during the reigns of Kings Peter IV, John I and Martin of Aragon, until the interregnum (1410-12) and the change of dynasty resulting from the Compromise of Caspe (1412). French courts, Avignon papal curia and the close personal, political and dynastic ties between the kingdoms of Sicily and Aragon constitute the background on which this paper studies the many echoes of Dante —from the Commedia, from the commentaries on Dante and from the so-called silloge boccaccesca— to be found around the chancellery and the court of Aragon: specifically, in Bernat Metge’s Llibre de Fortuna e Prud…
Cytomegalovirus and varicella–zoster virus vaccines in hematopoietic stem cell transplantation
2009
Impairment of cellular immunity upon hematopoietic stem cell transplantation (HSCT) may lead to serious clinical manifestations induced by human cytomegalovirus (HCMV) and varicella-zoster virus (VZV) infections. Although the clinical presentations, preferential organ involvement and clinical courses are different, infections with both herpesviruses are similar with respect to many pathophysiological aspects and the therapeutic strategies that are employed to combat them. Antiviral drug prophylaxis and therapy are successfully used to limit the risk of reactivated HCMV and VZV infections, but are unable to absolutely prevent episodes of virus disease in long-term follow-up after HSCT. Contr…
Human cytomegalovirus glycoprotein B genotypes in immunocompetent, immunocompromised, and congenitally infected Italian populations
2003
Human cytomegalovirus (HCMV) strains, obtained from immunocompetent and immunocompromised Italian hosts, were typed with glycoprotein B (gB) gene restriction analysis. A predominant circulation of HCMV strains with gB type 2 and 3 was detected in both the immunocompetent host with a primary HCMV infection and the immunocompromised host with or without HCMV disease. No association between gB types and subjects with different risks of developing HCMV disease was found. All four gB genotypes were capable of causing congenital infection in Italian babies, with gB type 1 accounting for 50% of the strains examined in symptomatic infants and a remarkable incidence of gB type 4 viruses.
INFEZIONE POLMONARE DA BLASTOSCHIZOMICES CAPITATUS
2005
Geotrichum capitatum, now known as Blastoschizomyces capitatus, can be responsible for several opportunistic infections (systemic infection or localized at lungs, liver, kidney, encephalitis or meningitis) in an immunocompromised host, especially in those patients affected by leukaemia or under immunosuppressive therapies. A 66-year-old woman with polimyosite under steroid and immunosuppressant therapy was hospitalized in ICU for an acute respiratory distress with moderate hypoxaemia and normocapnia. Pulmonary X-ray revealed a bilateral pneumonia. Hypoxaemia became severe 48 hours later and the patient underwent mechanical ventilation and empirical antibiotic therapy. Blood cultures, urine …