Search results for "Computer Science Applications"
showing 10 items of 3993 documents
Application of principal component analysis and wavelet transform to fatigue crack detection in waveguides
2010
Ultrasonic Guided Waves (UGWs) are a useful tool in structural health monitoring (SHM) applications that can benefit from built-in transduction, moderately large inspection ranges and high sensitivity to small flaws. This paper describes a SHM method based on UGWs, discrete wavelet transform (DWT), and principal component analysis (PCA) able to detect and quantify the onset and propagation of fatigue cracks in structural waveguides. The method combines the advantages of guided wave signals processed through the DWT with the outcomes of selecting defect-sensitive features to perform a multivariate diagnosis of damage. This diagnosis is based on the PCA. The framework presented in this paper …
The symmetric boundary element method for unilateral contact problems
2008
Abstract On the basis of the boundary integral equation method, in its symmetric formulation, the frictionless unilateral contact between two elastic bodies has been studied. A boundary discretization by boundary elements leads to an algebraic formulation in the form of a linear complementarity problem. In this paper the process of contact or detachment is obtained through a step by step analysis by using generalized (weighted) quantities as the check elements: the detachment or the contact phenomenon may happen when the weighted traction or the weighted displacement is greater than the weighted cohesion or weighted minimum reference gap, respectively. The applications are performed by usin…
The indirect force method
1990
Abstract It is known that the matrix force method shows some advantages over the displacement method for certain classes of problems, particularly in optimization and in the stress concentration analysis. Notwithstanding this, few efforts have been made to employ this method in engineering problems. In this paper, within the elastic analysis of frames and trusses, the indirect force method, utilizing beam-node type finite elements, is proposed. This method is based on the kinematical and mechanical study of nodes and of beams, the latter connected with the nodes by their first extremes according to a preliminary arrangement. In this formulation kinematical singularities are included, in the…
A coupled Finite Volume–Smoothed Particle Hydrodynamics method for incompressible flows
2016
Abstract An hybrid approach is proposed which allows to combine Finite Volume Method (FVM) and Smoothed Particle Hydrodynamics (SPH). The method is based on the partitioning of the computational domain into a portion discretized with a structured grid of hexahedral elements (the FVM-domain ) and a portion filled with Lagrangian particles (the SPH-domain ), separated by an interface made of triangular elements. A smooth transition between the solutions in the FVM and SPH regions is guaranteed by the introduction of a layer of grid cells in the SPH-domain and of a band of virtual particles in the FVM one (both neighboring the interface), on which the hydrodynamic variables are obtained throug…
A review of health assessment techniques for distribution transformers in smart distribution grids
2020
Due to the large number of distribution transformers in the distribution grid, the status of distribution transformers plays an important role in ensuring the safe and reliable operation of the these grids. To evaluate the distribution transformer health, many assessment techniques have been studied and developed. These tools will support the transformer operators in predicting the status of the distribution transformer and responding effectively. This paper will review the literature in the area, analyze the latest techniques as well as highlight the advantages and disadvantages of current methodologies.
Robust stabilisation of 2D state-delayed stochastic systems with randomly occurring uncertainties and nonlinearities
2013
This paper is concerned with the state feedback control problem for a class of two-dimensional (2D) discrete-time stochastic systems with time-delays, randomly occurring uncertainties and nonlinearities. Both the sector-like nonlinearities and the norm-bounded uncertainties enter into the system in random ways, and such randomly occurring uncertainties and nonlinearities obey certain mutually uncorrelated Bernoulli random binary distribution laws. Sufficient computationally tractable linear matrix inequality–based conditions are established for the 2D nonlinear stochastic time-delay systems to be asymptotically stable in the mean-square sense, and then the explicit expression of the desired…
Drivers, barriers and impacts of digitalisation in rural areas from the viewpoint of experts
2022
Abstract Context: The domain of rural areas, including rural communities, agriculture, and forestry, is going through a process of deep digital transformation. Digitalisation can have positive impacts on sustainability in terms of greater environmental control, and community prosperity. At the same time, it can also have disruptive effects, with the marginalisation of actors that cannot cope with the change. When developing a novel system for rural areas, requirements engineers should carefully consider the specific socio-economic characteristics of the domain, so that potential positive effects can be maximised, while mitigating negative impacts. Objective: The goal of this paper is to sup…
E-Learning in Pharmacology and Pharmacy
2011
Computer-based learning facilitates a shift from externally controlled to self-directed learning. Universities and other educational institutions are challenged by these developments and must react appropriately to meet the requirements of education. The term e-learning has been coined to describe a wide range of diverse learning and teaching strategies based on the use of electronic devices. Recently developed concepts in the science of education and learning provide appropriate frameworks for novel e-learning scenarios. The present review introduces strategies and concepts for the implementation of e-learning in academic and non-academic programs and gives an overview of current e-learnin…
Can NF-κB Be Considered a Valid Drug Target in Neoplastic Diseases? Our Point of View
2020
Multidrug resistance (MDR), of the innate and acquired types, is one of major problems in treating tumor diseases with a good chance of success. In this review, we examine the key role of nuclear factor-kappa B (NF-κB) to induce MDR in three tumor models characterized precisely by innate or acquired MDR, in particular triple negative breast cancer (TNBC), hepatocellular carcinoma (HCC), and acute myeloid leukemia (AML). We also present different pharmacological approaches that our group have employed to reduce the expression/activation of this transcriptional factor and thus to restore chemo-sensitivity. Finally, we examine the latest scientific evidence found by other groups, the most sign…
A multilevel object-oriented modelling methodology for physiologically-based pharmacokinetics (PBPK): Evaluation with a semi-mechanistic pharmacokine…
2019
Abstract Background and objective The aims of this study are (i) to assess the predictive reliability of the physiologically based software PhysPK versus the well-known population approach software NONMEM for the cited semi-mechanistic PK model, (ii) to determine whether these modelling approaches are interchangeable and (iii) to compare acausal with causal modelling approaches in the framework of semi-mechanistic PK models. Methods A semi-mechanistic model was proposed, which assumed oral administration of a solid dosage form with a peripheral compartment and two active metabolites. The model incorporates intestinal transit, dissolution limited by solubility, variable efflux transporter ex…