Search results for "Computer Science Applications"
showing 10 items of 3993 documents
Transcriptomic Analyses Reveal 2 and 4 Family Members of Cytochromes P450 (CYP) Involved in LPS Inflammatory Response in Pharynx of Ciona robusta
2021
Cytochromes P450 (CYP) are enzymes responsible for the biotransformation of most endogenous and exogenous agents. The expression of each CYP is influenced by a unique combination of mechanisms and factors including genetic polymorphisms, induction by xenobiotics, and regulation by cytokines and hormones. In recent years, Ciona robusta, one of the closest living relatives of vertebrates, has become a model in various fields of biology, in particular for studying inflammatory response. Using an in vivo LPS exposure strategy, next-generation sequencing (NGS) and qRT-PCR combined with bioinformatics and in silico analyses, compared whole pharynx transcripts from naïve and LPS-exposed C. robusta…
Time Response of Oxidative/Nitrosative Stress and Inflammation in LPS-Induced Endotoxaemia—A Comparative Study of Mice and Rats
2017
Sepsis is a severe and multifactorial disease with a high mortality rate. It represents a strong inflammatory response to an infection and is associated with vascular inflammation and oxidative/nitrosative stress. Here, we studied the underlying time responses in the widely used lipopolysaccharide (LPS)-induced endotoxaemia model in mice and rats. LPS (10 mg/kg; from Salmonella Typhosa) was intraperitoneally injected into mice and rats. Animals of every species were divided into five groups and sacrificed at specific points in time (0, 3, 6, 9, 12 h). White blood cells (WBC) decreased significantly in both species after 3 h and partially recovered with time, whereas platelet decrease did no…
Extracellular vesicles do not mediate the anti-inflammatory actions of mouse-derived adipose tissue mesenchymal stem cells secretome
2021
Este artículo se encuentra disponible en la siguiente URL: https://www.mdpi.com/1422-0067/22/3/1375 Este artículo pertenece al número especial "The Role of Mesenchymal Stem Cells on Inflammatory and Fibrotic Diseases". Adipose tissue represents an abundant source of mesenchymal stem cells (MSC) for therapeutic purposes. Previous studies have demonstrated the anti-inflammatory potential of adipose tissue-derived MSC (ASC). Extracellular vesicles (EV) present in the conditioned medium (CM) have been shown to mediate the cytoprotective effects of human ASC secretome. Nevertheless, the role of EV in the anti-inflammatory effects of mouse-derived ASC is not known. The current study has investiga…
Particle transport in recirculated liquid metal flows
2008
PurposeAims to present recent activities in numerical modeling of turbulent transport processes in induction crucible furnace.Design/methodology/approach3D large eddy simulation (LES) method was applied for fluid flow modeling in a cylindrical container and transport of 30,000 particles was investigated with Lagrangian approach.FindingsParticle accumulation near the side crucible boundary is determined mainly by the ρp/ρ ratio and according to the presented results. Particle settling velocity is of the same order as characteristic melt flow velocity. Particle concentration homogenization time depends on the internal flow regime. Separate particle tracks introduce very intensive mass exchang…
A decade of research into player communities in online games
2013
The social dynamics of player communities in online games have been the subject of much research during the last decade. Following a systematic review of empirical research publications from 2000–2010, this article synthesizes the key methods and concepts researchers have used to study and characterize player communities. It also synthesizes the key aspects and operationalizations researchers have concentrated on. The analysis shows that qualitative approaches have been more common than quantitative ones. The concepts used to characterize player communities were often not clearly defined or overlapped in meaning. Yet they revealed a prevalence of micro (groups or teams), meso (guilds or org…
Actitudes ante el aprendizaje en estudiantes universitarios excelentes y en estudiantes medios
2011
Pretendemos analizar lo que hacen los alumnos con mejor nota de entrada en la universidad que pueda explicar su rendimiento, de cara a precisar modelos eficaces de funcionamiento que se puedan generalizar y enseñar, en la medida de lo posible. Usando el cuestionario CEVAPU (Cuestionario de evaluación de las actitudes ante el aprendizaje de los estudiantes universitarios), evaluamos las actitudes ante el aprendizaje de un grupo de alumnos excelentes, seleccionados de 11 titulaciones de 9 centros de la Universidad Politécnica de Valencia, y comparamos los resultados con un grupo de N similar de alumnos medios de los mismos centros. Encontramos que los alumnos excelentes desarrollaban mejores …
Impact of LoRa Imperfect Orthogonality: Analysis of Link-Level Performance
2018
In this letter, we focus on the evaluation of link-level performance of LoRa technology, in the usual network scenario with a central gateway and high-density deployment of end-devices. LoRa technology achieves wide coverage areas, low power consumption and robustness to interference thanks to a chirp spread-spectrum modulation, in which chirps modulated with different spreading factors (SFs) are quasi-orthogonal. We focus on the performance analysis of a single receiver in presence of collisions. First, we analyze LoRa modulation numerically and show that collisions between packets modulated with different SFs can indeed cause packet loss if the interference power received is strong enough…
LoRa Technology Demystified: From Link Behavior to Cell-Level Performance
2020
In this paper we study the capability of LoRa technology in rejecting different interfering LoRa signals and the impact on the cell capacity. First, we analyze experimentally the link-level performance of LoRa and show that collisions between packets modulated with the same Spreading Factor (SF) usually lead to channel captures, while different spreading factors can indeed cause packet loss if the interference power is strong enough. Second, we model the effect of such findings to quantify the achievable capacity in a typical LoRa cell: we show that high SFs, generally seen as more robust, can be severely affected by inter-SF interference and that different criteria for deciding SF allocati…
Computer Science Outreach Workshop and Interest Development: A Longitudinal Study
2018
This longitudinal study investigates the impact of an extra-curricular programming workshop in student interest development in computer science. The workshop was targeted at 12–18-year old youngsters. A survey was sent to all previous participants with a known home address; 31.5% responded the survey (n = 197). This data was then combined with pre-workshop survey data, and analyzed with mixed methods. Positive development of interest was discovered for 57% of the respondents, of which nearly all attributed their interest increase to the workshop at least partly (92%). Qualitative inspection revealed that the workshop provided three anchors that facilitated students’ reengagement with progra…
Platelet-Rich Plasma (PRP) in Dental Extraction of Patients at Risk of Bisphosphonate-Related Osteonecrosis of the Jaws: A Two-Year Longitudinal Study
2020
: Dental extraction has often been described as the main trigger event of osteonecrosis of the jaws (ONJ). This longitudinal hospital-based study aimed to evaluate the outcome at 2 years of a standardized medical-surgical protocol for dental extraction, combined with platelet rich-plasma (PRP) application, compared with conventional protocol not combined with PRP or any other autologous platelet concentrate in cancer (ONC) and osteometabolic (OST) patients, at risk of bisphosphonate (BP)-related ONJ. Twenty patients were consecutively recruited: six received BPs for cancer skeletal-related events (34.17 ±