Search results for "Computer Science Applications"
showing 10 items of 3993 documents
Role of JAK/STAT in Interstitial Lung Diseases; Molecular and Cellular Mechanisms
2021
Interstitial lung diseases (ILDs) comprise different fibrotic lung disorders characterized by cellular proliferation, interstitial inflammation, and fibrosis. The JAK/STAT molecular pathway is activated under the interaction of a broad number of profibrotic/pro-inflammatory cytokines, such as IL-6, IL-11, and IL-13, among others, which are increased in different ILDs. Similarly, several growth factors over-expressed in ILDs, such as platelet-derived growth factor (PDGF), transforming growth factor β1 (TGF-β1), and fibroblast growth factor (FGF) activate JAK/STAT by canonical or non-canonical pathways, which indicates a predominant role of JAK/STAT in ILDs. Between the different JAK/STAT iso…
The Endometrial Microbiome and Its Impact on Human Conception
2021
Changes in the female genital tract microbiome are consistently correlated to gynecological and obstetrical pathologies, and tract dysbiosis can impact reproductive outcomes during fertility treatment. Nonetheless, a consensus regarding the physiological microbiome core inside the uterine cavity has not been reached due to a myriad of study limitations, such as sample size and experimental design variations, and the influence of endometrial bacterial communities on human reproduction remains debated. Understanding the healthy endometrial microbiota and how changes in its composition affect fertility would potentially allow personalized treatment through microbiome management during assisted…
Molecular Mechanisms Leading from Periodontal Disease to Cancer
2022
Periodontitis is prevalent in half of the adult population and raises critical health concerns as it has been recently associated with an increased risk of cancer. While information about the topic remains somewhat scarce, a deeper understanding of the underlying mechanistic pathways promoting neoplasia in periodontitis patients is of fundamental importance. This manuscript presents the literature as well as a panel of tables and figures on the molecular mechanisms of Porphyromonas gingivalis and Fusobacterium nucleatum, two main oral pathogens in periodontitis pathology, involved in instigating tumorigenesis. We also present evidence for potential links between the RANKL–RANK signaling axi…
Molecular Chaperones and Thyroid Cancer
2021
Thyroid cancers are the most common of the endocrine system malignancies and progress must be made in the areas of differential diagnosis and treatment to improve patient management. Advances in the understanding of carcinogenic mechanisms have occurred in various fronts, including studies of the chaperone system (CS). Components of the CS are found to be quantitatively increased or decreased, and some correlations have been established between the quantitative changes and tumor type, prognosis, and response to treatment. These correlations provide the basis for identifying distinctive patterns useful in differential diagnosis and for planning experiments aiming at elucidating the role of t…
Trajectory robust control of autonomous quadcopters based on model decoupling and disturbance estimation
2021
In this article, a systematic procedure is given for determining a robust motion control law for autonomous quadcopters, starting from an input–output linearizable model. In particular, the suggested technique can be considered as a robust feedback linearization (FL), where the nonlinear state-feedback terms, which contain the aerodynamic forces and moments and other unknown disturbances, are estimated online by means of extended state observers. Therefore, the control system is made robust against unmodelled dynamics and endogenous as well as exogenous disturbances. The desired closed-loop dynamics is obtained by means of pole assignment. To have a feasible control action, that is, the fo…
ROS/Gazebo-Based Simulation of Quadcopter Aircrafts
2018
The main purpose of this work is to present a tutorial description on how to design and develop an observer, which is capable of estimating the position and the orientation of a drone commanded by a controller, whose shape and structure are unknown. Starting from Newton's and Euler's laws, a mathematical model describing the dynamics of a quadcopter has first been obtained. By linearizing this model it is possible to implement a Luenberger observer and validate it with simulations in a Linux environment, thanks to the use of the Ardupilot controller and the Gazebo simulator. Finally, starting from the results obtained from the simulation, it is possible to evaluate the error made in the est…
Wind gust estimation for precise quasi-hovering control of quadrotor aircraft
2021
Abstract This paper focuses on the control of quadrotor vehicles without wind sensors that are required to accurately track low-speed trajectories in the presence of moderate yet unknown wind gusts. By modeling the wind disturbance as exogenous inputs, and assuming that compensation of its effects can be achieved through quasi-static vehicle motions, this paper proposes an innovative estimation and control scheme comprising a linear dynamic filter for the estimation of such unknown inputs and requiring only position and attitude information. The filter is built upon results from Unknown Input Observer theory and allows estimation of wind and vehicle state without measurement of the wind its…
NUMERICAL IMPLEMENTATION OF A K.A.M. ALGORITHM
1993
We discuss a numerical implementation of a K.A.M. algorithm to determine invariant tori, for systems that are quadratic in the action variables. The method has the advantage that the iteration procedure does not produce higher order terms in the actions, allowing thus a systematic control of the convergence.
On the accurate determination of nonisolated solutions of nonlinear equations
1981
A simple but efficient method to obtain accurate solutions of a system of nonlinear equations with a singular Jacobian at the solution is presented. This is achieved by enlarging the system to a higher dimensional one whose solution in question is isolated. Thus it can be computed e. g. by Newton's method, which is locally at least quadratically convergent and selfcorrecting, so that high accuracy is attainable.
Governance models of coopetition and innovation: the case of Spanish firms
2016
Although numerous studies show that cooperation relates strongly to obtaining benefits in business innovation, few researchers have considered the role of competition in this relationship. Nevertheless, it is expected that firms can boost their innovation if they cooperate with competitors and with intermediaries. The aim of this study was to observe whether coopeting firms achieve high degrees of innovation. To accomplish this aim, we used a sample of innovative firms from the region of Valencia (Spain). The chosen region has specific structural characteristics, which are discussed later. Although the sampled firms compete with one another, they also collaborate with each other and with in…