Search results for "Configuration"

Chiral cyclohexane based fluorescent chemosensors for enantiomeric discrimination of aspartate

2008

Some new chiral cyclohexyl based fluorescent anion receptors have been synthesized and their absolute configuration has been determined by using circular dichroism (CD). Complexation experiments have been carried out with several dicarboxylates, and stoichiometries and complexation constants for the corresponding complexes have been determined. The chiral discrimination ability of these ligands for chiral dicarboxylates has been studied and the best results have been obtained with TMA aspartate.

Prolin-benzylester als chirale Hilfsgruppen in asymmetrischen 1,3-dipolaren Cycloadditionen mit Nitriloxiden

1990

Proline Benzyl Esters as Chiral Auxiliaries in Asymmetric 1,3-Dipolar Cycloadditions N-Acryloylproline benzyl ester (1b) reacts with nitrile oxides at temperatures from −78 to 0°C to give isoxazolines 4/5 with diastereomeric ratios of ca. 3:1 and with the (5S) isomer as the predominating. The corresponding N-methacryloylproline benzyl ester (1c) gives inferior results. The diastereoselectivity is not influenced by the temperature and the substituents of the nitrile oxides. To prove the absolute configuration of the predominating stereoisomer, a reaction sequence is developed which makes use of an enantioselective hydrolysis with pig liver esterase as the key step to generate an optically ac…

Bis[S-hexyl 3-(thiophen-2-ylmethylidene)dithiocarbazato-κ2N3,S]palladium(II)

2016

In the title complex, [Pd(C12H17N2S3)2], the PdIIatom exhibits a square-planar coordination geometry with theN,S-chelating ligands arranged in atransconfiguration. Intramolecular C—H...S hydrogen bonds are observed. In the crystal, molecules are linked by weak C—H...N hydrogen-bond interactions, forming chains parallel to thebaxis.

Dynamic properties of successful plural leadership configuration: An exploratory process-study

2023

Our article introduces an exploratory process study of successful plural leadership configuration in searching for alternative solutions to wicked problems. The study was executed within four educational organisations that solved challenging wicked problems arising from today’s changing contexts. We argue that plural leadership configuration is a dynamic process when people in diverse organisational positions, roles, and levels design profitable endeavours through their ideas and activities, bring about desirable outcomes within diverse conditions and outline the future. We searched for potential systemic patterns, characteristics, and structure within this dynamic process. To find these p…

Sustainable virtual teams: promoting well-being through affect management training and openness to experience configurations

2021

A disruptive digitalization recently occurred that led to the fast adoption of virtual teams. However, membership diversity and team virtuality threaten members’ well-being, especially if faultlines appear (i.e., subgroups). Considering the job demands–resources model and the role of group affect in shaping members’ perceptions of well-being, we test the effectiveness of a short-term affect management training for increasing members’ eudaimonic well-being. Moreover, based on the trait activation theory and the contingent configuration approach, we draw on the personality composition literature to test how different openness to experience configurations of team level and diversity together m…

Struktur-Wirkungs-Beziehungen bei Histaminanaloga, 18. Mitt. Absolute Konfiguration und histaminartige Wirkung der Enantiomere von 5-Amino-4,5,6,7-te…

1979

Es werden die Racemattrennung von 5-Amino-4,5,6,7-tetrahydro-benzimidazol (3), die Bestimmung der absoluten Konfiguration sowie die histaminartige Wirksamkeit der Enantiomere am Ileum (H1) und Atrium (H2) des Meerschweinchens beschrieben. Structure-Activity Relationship of Histamine Analogues, XVIII: Absolute Configuration and Histamine-like Activity of the Enantiomers of 5-Amino-4,5,6,7-tetrahydrobenzimidazole The resolution of 5-amino-4,5,6,7-tetrahydrobenzimidazole (3), the determination of the absolute configuration and the histamine-like activity of the enantiomers on the guinea-pig ileum (H1) and atrium (H2) are reported.

Stereoselective Synthesis of the Antiprotozoal Lactone Passifloricin A and Seven Isomers Thereof

2004

The conjugated delta-lactone passifloricin A, a natural product with antiprotozoal activity, and seven isomers thereof have been synthesized in enantiopure form. It has been shown in this way that the proposed structure for the natural compound was erroneous. The correct structure is now evidenced. Key steps of the syntheses were asymmetric Brown-type aldehyde allylations and ring-closing metatheses.

Benefits of tiotropium/olodaterol compared with tiotropium in patients receiving COPD LAMA at baseline: pooled analysis of 4 clinical trials

2020

Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study

2019

On automatic algorithm configuration of vehicle routing problem solvers

2019

Many of the algorithms for solving vehicle routing problems expose parameters that strongly influence the quality of obtained solutions and the performance of the algorithm. Finding good values for these parameters is a tedious task that requires experimentation and experience. Therefore, methods that automate the process of algorithm configuration have received growing attention. In this paper, we present a comprehensive study to critically evaluate and compare the capabilities and suitability of seven state-of-the-art methods in configuring vehicle routing metaheuristics. The configuration target is the solution quality of eight metaheuristics solving two vehicle routing problem variants.…