Search results for "Consensus"

Obesity and cardiovascular risk

2018

: Obesity is a key factor for cardiovascular diseases and complications. Obesity is associated with hypertension, dyslipidemia and type II diabetes, which are the major predictors of cardiovascular disease in the future. It predisposes for atrial fibrillation, heart failure, sudden cardiac death, renal disease and ischemic stroke that are the main causes of cardiovascular hospitalization and mortality. As obesity and the cardiovascular effects on the vessels and the heart start early in life, even from childhood, it is important for health policies to prevent obesity very early before the disease manifestation emerge. Key roles in the prevention are strategies to increase physical exercise,…

Development of a European consensus from dentists, dental hygienists and physicians on a standard for oral health care in care-dependent older people…

2020

ObjectivesThis study aimed to obtain a consensus on oral health policy, access to dental care, oral hygiene measures and training levels.BackgroundPoor oral health is widespread in care-dependent older people, but no consensus for a minimum standard of oral health care exists yet.MethodsThe e-Delphi approach was applied to a selected panel of interdisciplinary experts. Data analysis was based on three measurements: (a) ≥70% of experts’ opinion fall into category “agree or strongly agree,” (b) median score on the 5-point Likert scale ≥4, (c) interquartile range ≤1.ResultsA total of 31 experts from 17 European countries participated in this survey. Agreement was achieved for a compulsory dent…

Italian consensus guidelines for chronic pancreatitis

2010

Computational cluster validation for microarray data analysis: experimental assessment of Clest, Consensus Clustering, Figure of Merit, Gap Statistic…

2008

Abstract Background Inferring cluster structure in microarray datasets is a fundamental task for the so-called -omic sciences. It is also a fundamental question in Statistics, Data Analysis and Classification, in particular with regard to the prediction of the number of clusters in a dataset, usually established via internal validation measures. Despite the wealth of internal measures available in the literature, new ones have been recently proposed, some of them specifically for microarray data. Results We consider five such measures: Clest, Consensus (Consensus Clustering), FOM (Figure of Merit), Gap (Gap Statistics) and ME (Model Explorer), in addition to the classic WCSS (Within Cluster…

Musculoskeletal ultrasound in hemophilia: Results and recommendations from a global survey and consensus meeting

2021

Abstract Introduction For persons with hemophilia, optimization of joint outcomes is an important unmet need. The aim of this initiative was to determine use of ultrasound in evaluating arthropathy in persons with hemophilia, and to move toward consensus among hemophilia care providers regarding the preferred ultrasound protocols for global adaptation. Methods A global survey of hemophilia treatment centers was conducted that focused on understanding how and why ultrasound was being used and endeavored to move toward consensus definitions of both point‐of‐care musculoskeletal ultrasound (POC‐MSKUS) and full diagnostic ultrasound, terminology to describe structures being assessed by ultrasou…

Mihi cane et populo: Cicerone e l’autorappresentazione del successo oratorio. La questione del consenso popolare (Cic. Brut. 183–200)

2022

Come si rappresenta il proprio successo? La tradizione poetica greca e latina conosce straordinarie immagini di consacrazioni delle virtù di poeta, elaborate con ricche e ornate costruzioni, la cui persistenza nella memoria letteraria ne assicura la vitalità. A fronte di tali esibizioni virtuosistiche, che dichiarano l’orgoglio del successo, ve ne sono altre, costruite altrettanto finemente ma dall’architettura più complessa, perché fondata su una più mediata strategia. Su una di queste, proveniente da un testo in prosa, ma da un autore quale Cicerone che ambiva non a caso anche al riconoscimento come poeta, vorrei provare a riflettere. Il passo in questione è un’ampia sequenza del Brutus (…

Improving Docking Performance Using Negative Image-Based Rescoring

2018

Despite the large computational costs of molecular docking, the default scoring functions are often unable to recognize the active hits from the inactive molecules in large-scale virtual screening experiments. Thus, even though a correct binding pose might be sampled during the docking, the active compound or its biologically relevant pose is not necessarily given high enough score to arouse the attention. Various rescoring and post-processing approaches have emerged for improving the docking performance. Here, it is shown that the very early enrichment (number of actives scored higher than 1% of the highest ranked decoys) can be improved on average 2.5-fold or even 8.7-fold by comparing th…

CONTRAHERE E ANIMUS CONTRAHENDI IN SALVIO GIULIANO

2022

The paper deals with the category of negotium in Salvius Iulianus. The author rejects the thesis according to which the jurist would have developed a concept of negotium as an objective relationship between two distinct assets. From the examination of Iul. 15 dig. D. 18.5.5 and Iul. 18 dig. D. 12.1.20 has rather taken shape the image of a jurist attentive to the will of the contracting parties, in the determination of id quod actum est.

LPV model identification for gain scheduling control: An application to rotating stall and surge control problem

2006

Abstract We approach the problem of identifying a nonlinear plant by parameterizing its dynamics as a linear parameter varying (LPV) model. The system under consideration is the Moore–Greitzer model which captures surge and stall phenomena in compressors. The control task is formulated as a problem of output regulation at various set points (stable and unstable) of the system under inputs and states constraints. We assume that inputs, outputs and scheduling parameters are measurable. It is worth pointing out that the adopted technique allows for identification of an LPV model's coefficients without the requirements of slow variations amongst set points. An example of combined identification…

Management of metabolic adverse events of targeted therapies and immune checkpoint inhibitors in cancer patients: an Associazione Italiana Oncologia …

2020

The growing insights in the next-generation immunotherapy and the state-of-the-art advancement in targeted-agents significantly improved clinical outcome of cancer patients by pointing towards a unexplored Achilles' heel. Novel toxicity profiles have been uncovered, representing unmet medical needs. Thus, a panel of expert provide comprehensive pharmacological and clinical evidence, to provide a patient-tailored approach to metabolic adverse events associated with novel anti-cancer treatments. Prompted by the need of a multidisciplinary cooperation, a working group of Associazione Italiana Oncologia Medica (AIOM), Associazione Medici Diabetologi (AMD) and Societa Italiana Farmacologia (SIF)…