Search results for "Cores"

showing 10 items of 72 documents

Examining facial emotion recognition as an intermediate phenotype for psychosis: Findings from the EUGEI study

2022

The EUGEI project was supported by the European Community’s Seventh Framework Program under grant agreement No. HEALTH-F2- 2009-241909 (Project EU-GEI). Dr. Arango was supported by the Spanish Ministry of Science and Innovation; Instituto de Salud Carlos III (SAM16-PE07CP1, PI16/02012, PI19/024); CIBERSAM (...)

AdultMalePsychosisGENETIC RISKInterviews as Topic03 medical and health sciencesSTRUCTURED INTERVIEW0302 clinical medicinePolygenic risk scoreRisk FactorsSocial cognitionIMPUTATIONmedicineHumansPOLYGENIC RISKEmotion recognitionAssociation (psychology)Biological PsychiatryEmotionPharmacologyIntermediate phenotypebusiness.industrySiblingsUNAFFECTED SIBLINGSRegression analysisASSOCIATIONGenomicsmedicine.diseaseSocial cognition030227 psychiatrySchizotypal traitsINDIVIDUALSPolygenic risk scoresPhenotypePsychotic DisordersSchizophreniaRELIABILITYStructured interviewSchizophreniaFemalebusinessFacial Recognition030217 neurology & neurosurgeryClinical psychologyProgress in Neuro-Psychopharmacology and Biological Psychiatry
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A Prognostic Enrichment Strategy for Selection of Patients With Acute Respiratory Distress Syndrome in Clinical Trials.

2019

Incomplete or ambiguous evidence for identifying high-risk patients with acute respiratory distress syndrome for enrollment into randomized controlled trials has come at the cost of an unreasonable number of negative trials. We examined a set of selected variables early in acute respiratory distress syndrome to determine accurate prognostic predictors for selecting high-risk patients for randomized controlled trials.A training and testing study using a secondary analysis of data from four prospective, multicenter, observational studies.A network of multidisciplinary ICUs.We studied 1,200 patients with moderate-to-severe acute respiratory distress syndrome managed with lung-protective ventil…

AdultMalemedicine.medical_specialtyOrgan Dysfunction ScoresMEDLINEAcute respiratory distressCritical Care and Intensive Care Medicinelaw.inventionRandomized controlled triallawMedicineHumansProspective StudiesIntensive care medicineProspective cohort studySelection (genetic algorithm)AgedRandomized Controlled Trials as TopicRespiratory Distress Syndromebusiness.industryPatient SelectionAge FactorsMiddle AgedPrognosisClinical trialMulticenter studyObservational studyFemalebusinessCritical care medicine
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Stratification for Identification of Prognostic Categories In the Acute RESpiratory Distress Syndrome (SPIRES) Score.

2021

OBJECTIVES: To develop a scoring model for stratifying patients with acute respiratory distress syndrome into risk categories (Stratification for identification of Prognostic categories In the acute RESpiratory distress syndrome score) for early prediction of death in the ICU, independent of the underlying disease and cause of death. DESIGN: A development and validation study using clinical data from four prospective, multicenter, observational cohorts. SETTING: A network of multidisciplinary ICUs. PATIENTS: One-thousand three-hundred one patients with moderate-to-severe acute respiratory distress syndrome managed with lung-protective ventilation. INTERVENTIONS: None. MEASUREMENTS AND MAIN …

AdultMalemedicine.medical_specialtyOrgan Dysfunction ScoresPsychological interventionMEDLINECritical Care and Intensive Care MedicineLogistic regressionSeverity of Illness IndexstratificationInternal medicinemedicineHumansProspective StudiesCause of deathAPACHEclinical trialsRespiratory Distress SyndromeReceiver operating characteristicbusiness.industryphenotypesscoring systemacute respiratory distress syndromeMiddle AgedPrognosisRespiration ArtificialIntensive Care UnitsROC CurveSpainArea Under CurveCohortBreathingoutcomeObservational studyFemalebusinessCritical care medicine
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Duration of untreated psychosis in first-episode psychosis is not associated with common genetic variants for major psychiatric conditions: results f…

2021

The EU-GEI Project is funded by the European Community’s Seventh Framework Programme under grant agreement No. HEALTH-F2-2010–241909 (Project EU-GEI).

Bipolar DisorderTime FactorsIntelligenceGenome-wide association studyDETERMINANTSpsychosi0302 clinical medicineInterquartile rangeSettore MED/48 -Scienze Infermierist. e Tecn. Neuro-Psichiatriche e Riabilitat.IMPUTATIONpolygenic scorepsychosis0303 health sciencesConfoundingEuropePsychiatry and Mental healthgenome-wide association studieSchizophreniaMajor depressive disorderlipids (amino acids peptides and proteins)Case-Control Studieduration of untreated psychosisBrazilHumanAdultPsychosismedicine.medical_specialtycongenital hereditary and neonatal diseases and abnormalitiesTime FactorAcademicSubjects/MED00810DISORDERS1ST EPISODEILLNESSPsychotic Disorderduration of untreated psychosi03 medical and health sciencesInternal medicinemedicineHumansBipolar disorderGENOME-WIDE ASSOCIATIONSettore MED/25 - PsichiatriaMETAANALYSIS030304 developmental biologyDepressive Disorder Majorbusiness.industryCOMPONENTSTREATMENT DELAYmedicine.diseaseTRANSTORNO BIPOLARschizophreniapolygenic scoresPsychotic DisordersCase-Control Studiesdupgenome-wide association studiesbusiness030217 neurology & neurosurgeryRegular ArticlesGenome-Wide Association Study
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Spanish Adaptation of the Inventory Brief Child Abuse Potential and the Protective Factors Survey

2021

Child maltreatment is a public health problem with different consequences depending on the form of abuse. Measuring risk and protective factors has been a fertile ground for research, without involving instruments with sufficient evidence of validity. The aim of the study was to gather evidence of validity and reliability of the Inventory Brief Child Abuse Potential (IBCAP) and Protective Factors Survey (PFS) in the Mexican population. The instruments were translated into Spanish. In a non-probabilistic sample of 200 participants, the 7-factor model for the IBCAP [comparative fit index (CFI) = 0.984; root mean square error of approximation (RMSEA) = 0.067] and the 4-factor model for the PFS…

Child abusemedicine.medical_specialtyreliabilitychild abusePublic health05 social sciencesDiscriminant validityValidity050109 social psychologySample (statistics)norms and interpretation of tests scoresStructural equation modelingBF1-990validity evidencesmedicinePsychologyprotective and risk factors0501 psychology and cognitive sciencesPsychologyGeneral PsychologyReliability (statistics)Original Research050104 developmental & child psychologyInterpretabilityClinical psychologyFrontiers in Psychology
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Diagnosis of familial hypercholesterolemia in a large cohort of Italian genotyped hypercholesterolemic patients

2022

Background and aims: Familial hypercholesterolemia (FH) is the most relevant genetic cause of early cardiovascular disease (CVD). FH is suspected when low density lipoprotein cholesterol (LDL-C) levels exceed the 95th percentile of the population distribution. Different diagnostic scoring systems have been developed, as the Dutch Lipid Clinic Network (DLCN) score, used worldwide. The aim of the study is to describe the characteristics of FH patients of a large cohort of more than eight hundred genotyped subjects enrolled in an Italian Lipid Clinic, and evaluate the DLCN score performance applied retrospectively to the case study. Methods: 836 hypercholesterolemic patients with LDL-C > 4.…

Cohort StudiesHyperlipoproteinemia Type IIHeterozygoteSettore MED/09 - Medicina InternaSettore BIO/12 - Biochimica Clinica E Biologia Molecolare ClinicaGeneticPredictive scoresFamilial hypercholesterolemiaHumansCholesterol LDLLipidCardiology and Cardiovascular MedicineRetrospective StudiesAtherosclerosis
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Assessment of the Current for a Non-Linear Power Inductor Including Temperature in DC-DC Converters

2023

A method for estimating the current flowing through a non-linear power inductor operating in a DC/DC converter is proposed. The knowledge of such current, that cannot be calculated in closed form as for the linear inductor, is crucial for the design of the converter. The proposed method is based on a third-order polynomial model of the inductor, already developed by the authors; it is exploited to solve the differential equation of the inductor and to implement a flux model in a circuit simulator. The method allows the estimation of the current up to saturation, intended as the point at which the differential inductance is reduced to half of its maximum value. The current profile depends al…

Computer Networks and Communicationsinductorsmagnetic coresnonlinear circuitsnonlinear network analysialgorithmsinductorSettore ING-INF/01 - ElettronicaAlgorithmmagnetic corenumerical simulationsferriteHardware and ArchitectureControl and Systems Engineeringnonlinear network analysisSignal ProcessingElectrical and Electronic Engineeringnonlinear circuitferritesElectronics
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Cores for parabolic operators with unbounded coefficients

2009

Abstract Let A = ∑ i , j = 1 N q i j ( s , x ) D i j + ∑ i = 1 N b i ( s , x ) D i be a family of elliptic differential operators with unbounded coefficients defined in R N + 1 . In [M. Kunze, L. Lorenzi, A. Lunardi, Nonautonomous Kolmogorov parabolic equations with unbounded coefficients, Trans. Amer. Math. Soc., in press], under suitable assumptions, it has been proved that the operator G : = A − D s generates a semigroup of positive contractions ( T p ( t ) ) in L p ( R N + 1 , ν ) for every 1 ⩽ p + ∞ , where ν is an infinitesimally invariant measure of ( T p ( t ) ) . Here, under some additional conditions on the growth of the coefficients of A , which cover also some growths with an ex…

Discrete mathematicsSemigroupApplied MathematicsNonautonomous parabolic equationsCharacterization (mathematics)Differential operatorParabolic partial differential equationCombinatoricsOperator (computer programming)Cover (topology)Evolution operatorsGradient estimatesCoresInfinitesimal generatorInvariant measureInvariant measuresAnalysisMathematicsJournal of Differential Equations
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Relative age at school entry, school performance and long-term labour market outcomes

2015

This article examines the impact of relative age at school entry on school performance, educational attainment and labour market outcomes later in life. We find that the advantages of maturity at school entry are short-lived with relative age having no impact on the years of formal education, adulthood earnings or employment. Our findings are consistent with the view that assumes modest maturity effects in countries where formal education begins late and there are no ability-differentiated learning groups at initial grades. peerReviewed

Economics and EconometricsLabour economicsta511Earningstest scores4. Educationeducationlabour market outcomesta5142School entryMaturity (finance)Educational attainmentTerm (time)relative ageSchool performanceFormal education8. Economic growthEconomicsschool entryApplied Economics Letters
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Frailty and emergency surgery in the elderly: protocol of a prospective, multicenter study in Italy for evaluating perioperative outcome (The FRAILES…

2018

Improvements in living conditions and progress in medical management have resulted in better quality of life and longer life expectancy. Therefore, the number of older people undergoing surgery is increasing. Frailty is often described as a syndrome in aged patients where there is augmented vulnerability due to progressive loss of functional reserves. Studies suggest that frailty predisposes elderly to worsening outcome after surgery. Since emergency surgery is associated with higher mortality rates, it is paramount to have an accurate stratification of surgical risk in such patients. The aim of our study is to characterize the clinicopathological findings, management, and short-term outcom…

Elderly patient; Emergency surgery; Frailty; Geriatric; Risk assessment; Scores; Aged; Aged 80 and over; Clinical Protocols; Emergencies; Female; Frailty; Humans; Italy; Logistic Models; Male; Multivariate Analysis; Outcome Assessment Health Care; Postoperative Complications; Prognosis; Prospective Studies; ROC Curve; Risk Assessment; Frail ElderlyMaleOutcome Assessment030230 surgerylaw.invention0302 clinical medicinePostoperative ComplicationsQuality of lifeClinical ProtocolslawOutcome Assessment Health Care80 and overProspective StudiesProspective cohort studyMultivariate AnalysiAged 80 and overEmergencieFrailtyMortality rateScoreScoresPrognosisIntensive care unitElderly patient; Emergency surgery; Frailty; Geriatric; Risk assessment; Scores; Aged; Aged 80 and over; Clinical Protocols; Emergencies; Female; Frailty; Humans; Italy; Logistic Models; Male; Multivariate Analysis; Outcome Assessment (Health Care); Postoperative Complications; Prognosis; Prospective Studies; ROC Curve; Risk Assessment; Frail ElderlyItaly030220 oncology & carcinogenesiselderly patient emergency surgery frailty geriatric risk assessment scoresEmergency surgeryFemaleRisk assessmentElderly patientHumanmedicine.medical_specialtyElderly patient; Emergency surgery; Frailty; Geriatric; Risk assessment; Scores;Logistic ModelPrognosiFrail ElderlyRisk AssessmentNO03 medical and health sciencesOutcome Assessment (Health Care)medicineHumansClinical ProtocolAgedbusiness.industryPerioperativeElderly patient; Emergency surgery; Frailty; Geriatric; Risk assessment; ScoresSurgeryHealth CareProspective StudieSettore MED/18 - Chirurgia GeneraleLogistic ModelsROC CurveEmergency medicineMultivariate AnalysisLife expectancyObservational studySurgeryPostoperative ComplicationEmergenciesbusinessGeriatric
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