Search results for "Course"
showing 10 items of 1744 documents
a1D-Adrenoceptors are responsible for the high sensitivity and the slow time-course of noradrenaline-mediated contraction in conductance arteries.
2013
The objective of this study was to determine whether the different time-course characteristics of α1-adrenoceptor-mediated contraction in arteries can be related to the subtypes involved. Contractile responses to noradrenaline (NA) were compared with inositol phosphate accumulation and extracellular signal-regulated kinase (ERK)1/2 phosphorylation after α1-agonist stimuli in the same vessels in the presence or absence of α1-antagonists in rat or in α1-subtype knockout (KO) mice. Aorta, where α1D-AR is the main functional subtype, had higher sensitivity to NA (in respect of inositol phosphate [IP], pERK1/2, and contractile response) than tail artery, where the α1A-adrenoceptor subtype is pre…
“Sexuality does not belong to the game” : Discourses in Overwatch Community and the Privilege of Belonging
2022
Players can experience a sense of belonging to videogames and the transmedial worlds surrounding them. There nevertheless exist ongoing negotiations over who has the right to belong to these spaces. Multiple works addressing related issues have highlighted that white heterosexual men still maintain the position of power in the majority of game communities (e.g., Consalvo, 2012; Paul, 2018). This position can translate into an ease of belonging while others can find themselves struggling for the right to belong. We examine the transmedial world of Overwatch, an online game, as a place of belonging and non-belonging. Since the game’s launch, two characters have been revealed as queer. In cont…
Temperature affects the ontogeny of sexually dimorphic cuticular hydrocarbons inDrosophila melanogaster
2002
0022-0949 (Print) Journal Article Research Support, Non-U.S. Gov't; Hydrocarbons on the cuticle of mature Drosophila melanogaster flies play a crucial role in mate recognition, and protect against dehydration. We measured the effect of temperature on mature cuticular hydrocarbons (CHs) by (i) rearing two control strains at different temperatures, (ii) shifting the temperature after metamorphosis and (iii) inducing a single heat-shock pulse in control and heat-sensitive transgenic strains, over a period of 3 days following adult eclosion. This study describes the time course of the events involved in the production of male- and female-predominant CHs. We also found that 'immature' CHs, sexua…
Locus of control as a mediator of the association between attachment and children’s mental health
2019
Locus of control-the expectation that one is in control of one's outcomes in life-is linked to well-being. The authors explored one of the possible antecedents of locus of control such as secure children's attachment. The hypothesis was that locus of control acts as a mediator of the association between children's attachment and their mental health, in terms of depression, anxiety (internalizing problems), and aggression (externalizing problems). Participants were 206 children with ages ranging from 8 to 14 years. The authors obtained data from teachers as well as by self-report. Structural equations modelling yielded significant results for both a direct path from insecure attachment to in…
The Impact of Abuse and Learning Difficulties on Emotion Understanding in Late Childhood and Early Adolescence
2014
Children's affective experiences and cognitive abilities have an impact on emotion understanding. However, their relative contribution, as well as the possibility of an interaction between them, has rarely been examined. The aim of the present study was to evaluate the influence of severe abuse and learning difficulties on simple and complex components of emotion understanding in late childhood and early adolescence. A total of 28 older children and young adolescents were selected for the study. Half of the participants had suffered from severe abuse, and half of these abused children additionally had learning disabilities. The remaining half of the sample had no history of abuse but were m…
The Prevalence of sexual abuse in institutions : Results from a representative population-based sample in Germany
2018
The lifetime prevalence of sexual abuse in institutional settings in Germany was examined in a sample representative of the general adult population (N = 2,437). Participants completed a survey on whether they had ever experienced such abuse, its nature (contact, noncontact, forced sexual, intercourse), the type of institution (e.g. school, club), and the relationship of perpetrator to victim (peer, caregiver, staff member). Overall, 3.1% of adult respondents (women: 4.8%, men: 0.8%) reported having experienced some type of sexual abuse in institutions. Adult women reported higher rates of all types than did men, with rates of 3.9% versus 0.8% for contact sexual abuse, 1.2% versus 0.3% for …
Daily energy expenditure through the human life course
2021
Total daily energy expenditure (“total expenditure”, MJ/d) reflects daily energy needs and is a critical variable in human health and physiology, yet it is unclear how daily expenditure changes over the life course. Here, we analyze a large, globally diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 yr. We show that total expenditure is strongly related to fat free mass in a power-law manner and identify four distinct metabolic life stages. Fat free mass-adjusted daily expenditure accelerates rapidly in neonates (0-1yr) to ~46% above adult values at ~1 yr, declines slowly throughout childhood and adolescence (1-20 yr) t…
Infant and childhood growth and frailty in old age : the Helsinki Birth Cohort Study
2018
BackgroundEvidence from life course studies highlights the importance of infant and childhood growth as risk factors for adulthood chronic diseases.MethodsIn this sub-study of the Helsinki Birth Cohort Study, we studied 1078 individuals who had both information on body size from birth to 12 years of age and who were assessed for frailty according to the Fried criteria at the mean age of 71 years.ResultsGreater BMI gain between 2 and 11 years in boys was associated with frailty in old age (age-adjusted RRR 2.36, 95% CI 1.21, 4.63). No similar associations were observed in girls.ConclusionsMen who were frail in old age experienced accelerated BMI gain in childhood compared with those men who …
Midlife Cardiovascular Status and Old Age Physical Functioning Trajectories in Older Businessmen
2019
Objectives The associations between cardiovascular disease (CVD) risk and later physical functioning have been observed, but only a few studies with follow-up into old age are available. We investigated the association between cardiovascular status in midlife and physical functioning trajectories in old age. Design Prospective cohort study. Setting Helsinki Businessmen Study. Participants We studied white men born between 1919 and 1934 in the Helsinki Businessmen Study (HBS, initial n = 3490). Measurements Three CVD status groups were formed based on clinical measurements carried out in 1974: signs of CVD (diagnosed clinically or with changes in ECG, chronic disease present or used medicati…
The relationship between parenting and the economic orientation and behavior of Norwegian adolescents.
2013
Little is known about the economic socialization of children and adolescents and the role of parents in this process. The authors' purpose was to explore the role of parenting in the intergenerational transfer of economic orientation and economic behavior. More specifically, they studied the link between four parenting dimensions (parental warmth-responsiveness, behavioral control, psychological control, autonomy granting), three parenting styles (authoritative, authoritarian, and neglectful) and adolescents' conscientiousness, future time perspective, and present hedonistic orientation. The authors also studied the relationships between these dispositions and the adolescents' spending pref…