6533b825fe1ef96bd1281fb0
RESEARCH PRODUCT
Daily energy expenditure through the human life course
Kirsi H. PietiläinenJames P. MortonRoberto A RabinovichMarjije B. HoosEstelle V. LambertWilliam W. WongPascal BovetAnnemiek M. C. P. JoosenJennifer RoodEllen E. BlaakSumei HuSamuel S. UrlacherAnders SjödinUlf EkelundKlaas R. WesterterpCatherine HamblyMisaka KimuraPeter T. KatzmarzykEric SticeTeresa A. NicklasLene Frost AndersenXueying ZhangXueying ZhangAlberto G. BonomiGeorge S. WilsonGiulio ValentiGiulio ValentiBarry W. FudgeCornelia U LoechlIssaad BaddouAlbertine J. SchuitStéphane BlancStéphane BlancBrian M. WoodBrian M. WoodYannis P. PitsiladisAlexia J. Murphy-alfordJames C MorehenJames C MorehenEdgar A. Van MilSusan B. RacetteNader LessanKweku Bedu-addoCarlijn V. C. BoutenDale A. SchoellerErwin P. MeijerDavid A. RaichlenWilliam E. KrausRebecca M. ReynoldsJonathan C. K. WellsTerrence ForresterJamie A. CooperHerman PontzerLara R. DugasLenore ArabMarian L. NeuhouserAsmaa El HamdouchiHiroyuki SagayamaTsukasa YoshidaKitty P. KempenJack A. YanovskiEric RavussinGuy PlasquiSai Krupa DasAnine Christine MedinAnine Christine MedinMaciej S. BuchowskiPhilip N. AinslieNancy F. ButteMichael GurvenStefan G J A CampsGraeme L. CloseLudo M. Van EttenCorby K. MartinWilliam R. LeonardLiam AndersonRoss L. PrenticeRobert F. KushnerAmy LukeRichard CooperAnnelies H. C. GorisNoorjehan JoonasRobert OjiamboSusan B. RobertsSonja EntringerSonja EntringerJohn R. SpeakmanJacob Plange-rhuleYosuke Yamadasubject
MaleAging030309 nutrition & dietetics[SDV]Life Sciences [q-bio]BASAL METABOLIC-RATELONGITUDINAL ASSESSMENTCHILDRENVDP::Technology: 500::Electrotechnical disciplines: 540SDG 3 – Goede gezondheid en welzijnRC12000302 clinical medicinePregnancy80 and overGlobal healthWATER030212 general & internal medicineDEPOSITIONYoung adultChildAged 80 and over2. Zero hunger0303 health sciencesMultidisciplinaryMiddle AgedHuman development (humanity)Child PreschoolSLEEP DURATIONBody CompositionLife course approachFemaleIAEA DLW Database ConsortiumAdultAdolescentGeneral Science & TechnologyDoubly labeled waterArticleYoung Adult03 medical and health sciencesSDG 3 - Good Health and Well-beingmedicineHumansExercise physiologyPreschoolExerciseAgedNutritionPregnancyORGAN SIZEbusiness.industryBody WeightInfant NewbornInfantNewbornmedicine.diseaseCELLULAR-LEVEL APPROACHPHYSICAL-ACTIVITYBasal metabolic rateBasal MetabolismEnergy MetabolismbusinessREQUIREMENTSDemographydescription
Total daily energy expenditure (“total expenditure”, MJ/d) reflects daily energy needs and is a critical variable in human health and physiology, yet it is unclear how daily expenditure changes over the life course. Here, we analyze a large, globally diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 yr. We show that total expenditure is strongly related to fat free mass in a power-law manner and identify four distinct metabolic life stages. Fat free mass-adjusted daily expenditure accelerates rapidly in neonates (0-1yr) to ~46% above adult values at ~1 yr, declines slowly throughout childhood and adolescence (1-20 yr) to adult levels at ~20 yr, remains stable in adulthood (20-60 yr) even during pregnancy, and declines in older adults (60+ yr). These changes in total expenditure shed new light on human development and aging and should help shape nutrition and health strategies across the lifespan.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-08-13 | Science |