Search results for "Cover"
showing 10 items of 5959 documents
Opportunity Discovery and Creation in Cloud Computing
2013
Cloud computing provides opportunities for firms selling or using cloud services. However, little is known about how entrepreneurs discover or create these opportunities for cloud computing. In this study, we found that the opportunities discovered in cloud computing were related to the development of software for a particular need. By contrast, created opportunities were developed under conditions of technological uncertainty, at a time when the market did not yet exist. It appears that created opportunities, if successful, bring long-term competitive advantages, whereas discovered opportunities are more easily copied and exploited by competitors. peerReviewed
El impacto del cambio climático en la movilidad humana : las migraciones climáticas en el contexto internacional y europeo
2021
For decades, the migration phenomenon has been one of the thorniest regulatory issues in the European Union (EU) policy. In addition, today, the fight against climate change in all regions of the world makes the situation worse for the new ?climate refugees? or ?environmental displaced people?, whose legal status is not yet covered by the ancient 1951 Refugee Convention.
The transformation of a building of the 1970s into a contemporary sustainable building in the Mediterranean Basin
2008
The paper shows the design strategies adopted by a group of graduands of the Faculty of Building Engineering at the University of Palermo involved in a research project aimed to analyse the problems related to the renovation of modern buildings and to solve them by using sustainable approach. In particular, the aim of the research is to investigate these problems in the context of the Mediterranean Basin by adopting, when possible, design criteria inherited by the traditional architecture where sustainable design strategies were used unconsciously. The graduands thesis consists in the transformation of Mazara City Hall into the new "Satiro Danzante Museum" by using natural ventilation syste…
Thiazole Analogues of the Marine Alkaloid Nortopsentin as Inhibitors of Bacterial Biofilm Formation
2020
Anti-virulence strategy is currently considered a promising approach to overcome the global threat of the antibiotic resistance. Among different bacterial virulence factors, the biofilm formation is recognized as one of the most relevant. Considering the high and growing percentage of multi-drug resistant infections that are biofilm-mediated, new therapeutic agents capable of counteracting the formation of biofilms are urgently required. In this scenario, a new series of 18 thiazole derivatives was efficiently synthesized and evaluated for its ability to inhibit biofilm formation against the Gram-positive bacterial reference strains Staphylococcus aureus ATCC 25923 and S. aureus ATCC 6538 a…
Synthesis, antiproliferative activity, and in silico insights of new 3-benzoylamino-benzo[ b ]thiophene derivatives
2014
A new series of 3-benzoylamino-5-imidazol-5-yl-benzo[b]thiophenes and the parent amino derivatives were synthesized and screened as antitumor agents. All tested compounds showed concentration-dependent antiproliferative activity profile against HeLa cell line, exhibiting GI50 values in the low micromolar range. The most active compounds were tested in cell cycle perturbation experiments. A rapid accumulation of cells in the G2/M phase, with a concomitant reduction of cells in both the S and G0/G1 phases, was observed, suggesting that cell exposure to selected derivatives produces mitotic failure. To rationalize the biological results, the 3-benzoylamino-benzo[b]thiophenes were analyzed thro…
Evolutionary advantage conferred by an eukaryote-to-eukaryote gene transfer event in wine yeasts
2015
Although an increasing number of horizontal gene transfers have been reported in eukaryotes, experimental evidence for their adaptive value is lacking. Here, we report the recent transfer of a 158-kb genomic region between Torulaspora microellipsoides and Saccharomyces cerevisiae wine yeasts or closely related strains. This genomic region has undergone several rearrangements in S. cerevisiae strains, including gene loss and gene conversion between two tandemly duplicated FOT genes encoding oligopeptide transporters. We show that FOT genes confer a strong competitive advantage during grape must fermentation by increasing the number and diversity of oligopeptides that yeast can utilize as a s…
Minimizing fleet operating costs for a container transportation company
2006
Abstract This paper focuses on a fleet management problem that arises in container trucking industry. From the container transportation company perspective, the present and future operating costs to minimize can be divided in three components: the routing costs, the resource (i.e., driver and truck) assignment costs and the container repositioning costs (i.e., the costs of restoring a given container fleet distribution over the serviced territory, as requested by the shippers that own the containers). This real-world problem has been modeled as an integer programming problem. The proposed solution approach is based on the decomposition of this problem in three simpler sub-problems associate…
Dipeptidyl Enoates As Potent Rhodesain Inhibitors That Display a Dual Mode of Action
2015
Dipeptidyl enoates were prepared through a high-yielding two-step synthetic route. They have a dipeptidic structure with a 4-oxoenoate moiety as a warhead with multiple reactive sites. Dipeptidyl enoates were screened against rhodesain and human cathepsins B and L, and were found to be potent and selective inhibitors of rhodesain. Among them (S,E)-ethyl 5-((S)-2-{[(benzyloxy)carbonyl]amino}-3-phenylpropanamido)-7-methyl-4-oxooct-2-enoate (6) was the most potent, with an IC50 value of 16.4 nm and kinact/Ki=1.6×106 m−1 s−1 against rhodesain. These dipeptidyl enoates display a reversible mode of inhibition at very low concentrations and an irreversible mode at higher concentrations. Inhibition…
An evaluation of cool season turfgrassess in order to identify the species and varieties most suitable for the Mediterranean environment
2004
The cultivars of cool season Graminae species diffusely used to establish turfgrasses, are grown in northern areas of Europe. The aim of the research described in this paper was to identify the turfgrass species and cultivars most suitable for the Mediterranean environment. The trial was carried out in 1999 and 2000 at the experimental farm “Parco d’Orleans” belonging to the Department A.C.E.P. of University of Palermo. During the trial sixty different cultivars of cool season turf species were compared – 20 cultivars of Festuca arundinacea Schreb., 20 cultivars of Poa pratensis L., and 20 cultivars of Lulium perenne L. The main biometric and qualitative parameters examined were ground cove…
Experimental Evolution Reveals a Genetic Basis for Membrane-Associated Virus Release
2021
Many animal viruses replicate and are released from cells in close association to membranes. However, whether this is a passive process or is controlled by the virus remains poorly understood. Importantly, the genetic basis and evolvability of membrane-associated viral shedding have not been investigated. To address this, we performed a directed evolution experiment using coxsackievirus B3, a model enterovirus, in which we repeatedly selected the free-virion or the fast-sedimenting membrane-associated viral subpopulations. The virus responded to this selection regime by reproducibly fixing a series of mutations that altered the extent of membrane-associated viral shedding, as revealed by fu…