Search results for "Cripto"
showing 10 items of 863 documents
SeqEditor: an application for primer design and sequence analysis with or without GTF/GFF files
2021
[Motivation]: Sequence analyses oriented to investigate specific features, patterns and functions of protein and DNA/RNA sequences usually require tools based on graphic interfaces whose main characteristic is their intuitiveness and interactivity with the user’s expertise, especially when curation or primer design tasks are required. However, interface-based tools usually pose certain computational limitations when managing large sequences or complex datasets, such as genome and transcriptome assemblies. Having these requirments in mind we have developed SeqEditor an interactive software tool for nucleotide and protein sequences’ analysis.
DRUDIT: Web-based DRUgs DIscovery Tools to design small molecules as modulators of biological targets
2019
Abstract Motivation New in silico tools to predict biological affinities for input structures are presented. The tools are implemented in the DRUDIT (DRUgs DIscovery Tools) web service. The DRUDIT biological finder module is based on molecular descriptors that are calculated by the MOLDESTO (MOLecular DEScriptors TOol) software module developed by the same authors, which is able to calculate more than one thousand molecular descriptors. At this stage, DRUDIT includes 250 biological targets, but new external targets can be added. This feature extends the application scope of DRUDIT to several fields. Moreover, two more functions are implemented: the multi- and on/off-target tasks. These tool…
Efficient differentiation of embryonic stem cells into mesodermal precursors by BMP, retinoic acid and Notch signalling
2012
The ability to direct differentiation of mouse embryonic stem (ES) cells into specific lineages not only provides new insights into the pathways that regulate lineage selection but also has translational applications, for example in drug discovery. We set out to develop a method of differentiating ES cells into mesodermal cells at high efficiency without first having to induce embryoid body formation. ES cells were plated on a feeder layer of PA6 cells, which have membrane-associated stromal-derived inducing activity (SDIA), the molecular basis of which is currently unknown. Stimulation of ES/PA6 co-cultures with Bone Morphogenetic Protein 4 (BMP4) both favoured self-renewal of ES cells and…
Comparison of leaf surface roughness analysis methods by sensitivity to noise analysis
2015
International audience; Surface roughness is of great interest in agricultural spraying because it is used to characterise leaf surface wettability to predict the behaviour of droplets on a leaf surface. In recent years, the use of texture analysis to estimate surface roughness has emerged. In this paper we propose to estimate leaf surface roughness by using an optimisation of the Generalized Fourier Descriptors method. This approach is then compared with two other standard methods in the literature, one based on grey level intensity variation and the other on wavelet decomposition. Since roughness has many definitions and each method is calculated differently, we propose a new approach to …
MODOMICS: a database of RNA modification pathways—2013 update
2012
MODOMICS is a database of RNA modifications that provides comprehensive information concerning the chemical structures of modified ribonucleosides, their biosynthetic pathways, RNA-modifying enzymes and location of modified residues in RNA sequences. In the current database version, accessible at http://modomics.genesilico.pl, we included new features: a census of human and yeast snoRNAs involved in RNA-guided RNA modification, a new section covering the 5′-end capping process, and a catalogue of ‘building blocks’ for chemical synthesis of a large variety of modified nucleosides. The MODOMICS collections of RNA modifications, RNA-modifying enzymes and modified RNAs have been also updated. A…
Targeted NGS for species level phylogenomics: “made to measure” or “one size fits all”?
2017
Targeted high-throughput sequencing using hybrid-enrichment offers a promising source of data for inferring multiple, meaningfully resolved, independent gene trees suitable to address challenging phylogenetic problems in species complexes and rapid radiations. The targets in question can either be adopted directly from more or less universal tools, or custom made for particular clades at considerably greater effort. We applied custom made scripts to select sets of homologous sequence markers from transcriptome and WGS data for use in the flowering plant genus Erica (Ericaceae). We compared the resulting targets to those that would be selected both using different available tools (Hyb-Seq; M…
Il dottorato di ricerca sull’ambiente costruito: criticità e prospettive a partire dall’esperienza OSDOTTA 2010 / The PhD on the built environment: c…
2011
L’esperienza del Seminario in OSDOTTA 2010 si è svolta in uno scenario di profonde trasformazioni dell’assetto generale dell’Università. Il testo sviluppa i seguenti paragrafi: Impatto sul dottorato di alcuni provvedimenti governativi e ministeriali di recente emanazione; 2. I dati sull’inserimento professionale dei dottori di ricerca; 3. I corsi di dottorato in Tecnologia dell’Architettura e l’accorpamento dei Settori Scientifico-disciplinari; 4. Esiti a lungo termine dei corsi di dottorato: le competenze acquisite; 5. Esiti a breve termine dei corsi di dottorato: le tesi; 6. Il tema Permanenze e innovazioni nell’architettura del Mediterraneo in OSDOTTA 2010. The OSDOTTA 2010 workshop took…
Ripensare il curricolo a partire dai learning outcomes. Un’indagine esplorativa nel CdS-L19 dell’Università di Catania per sostenere processi di camb…
2021
Il presente contributo descrive l’indagine esplorativa avviata a seguito dell’analisi dei dati emersi dalla sperimentazione TECO-D/ Pedagogia alla quale ha partecipato il CdS L-19 dell’Università di Catania. I risultati della somministrazione dei test agli studenti hanno indotto le Autrici a operare una riflessione sul contributo che le discipline del curricolo della L-19 forniscono al raggiungimento dei contenuti core definiti dalla sperimentazione. Grazie a uno strumento di rilevazione appositamente creato, è stato chiesto a tutti i docenti del CdS di operare una riflessione sul contributo che l ’ i n s e g n a m e n t o p r o f e s s a t o o f f r e a l raggiungimento degli obiettivi for…
Análisis criptopaleontológico del lapidario de Teofrasto (s. III a.C.)
2013
The work “Perì líthon” or Teofrasto’s “Treatise of stones” has been considered the oldest text still available about minerals and rocks, even though it has remained incomplete. In this paper, the study of its contents shows that eleven of the stones called by geographic or cryptic names are either fossils from plants or vertebrates or chemical fossils. Therefore, the “Perì líthon” should also be considered as the oldest known treatise about palaeontology, because in addition to the fossils mentioned, it refers specifically to the fossilisation process.La obra “Perì líthon” o “Tratado de Piedras” de Teofrasto, es considerado el texto más antiguo conservado sobre minerales y rocas, aunque hay…
Qualità della didattica universitaria e sviluppo della capacità decisionale. Il modello ADVP per garantire i passaggi da L-19 a LM-85bis.
2020
Il presente contributo intende offrire una riflessione sulle competenze attese individuate attraverso la formulazione dei descrittori di Dublino dei CdS in Scienze dell’Educazione (L-19) e Scienze della Formazione Primaria (LM-85bis) istituiti presso l’Ateneo di Palermo e nello stesso tempo proporre un modello per lo sviluppo della maturità professional e necessaria a garantire scelte consapevoli, mature e responsabili. L’analisi condotta ci ha permesso, in una seconda fase di individuare gli obiettivi formativi finali scelti seguendo il modello proposto dalle Linee Guida dell ’Anvur, e di scegliere il modello dell’Activaction du Developpement Vocationnel et Personnel quale strumento per lo…