Search results for "Cutaneous"

Suppression of extinction with TMS in humans: from healthy controls to patients.

2006

We review a series of studies exemplifying some applications of single-pulse and paired-transcranial magnetic stimulation (TMS) in the study of spatial attention and of its deficits. We will focus primarily on sensory extinction, the failure to consciously perceive a contralesional sensory stimulus only during bilateral stimulation of homologous surfaces. TMS studies in healthy controls show that it is possible either to interfere or modulate the excitability of the parietal cortex during sensory (i.e. tactile and visual) attentional tasks, thus reproducing a condition of virtual extinction. TMS studies in patients with unilateral (mainly right) brain damage show that the modulation of the …

Mosaic activating mutations in GNA11 and GNAQ are associated with phakomatosis pigmentovascularis and extensive dermal melanocytosis

2016

Common birthmarks can be an indicator of underlying genetic disease but are often overlooked. Mongolian blue spots (dermal melanocytosis) are usually localized and transient, but they can be extensive, permanent, and associated with extracutaneous abnormalities. Co-occurrence with vascular birthmarks defines a subtype of phakomatosis pigmentovascularis, a group of syndromes associated with neurovascular, ophthalmological, overgrowth, and malignant complications. Here, we discover that extensive dermal melanocytosis and phakomatosis pigmentovascularis are associated with activating mutations in GNA11 and GNAQ, genes that encode Gα subunits of heterotrimeric G proteins. The mutations were det…

The waiting time for prostate cancer treatment in Italy: analysis from the PROS-IT CNR Study.

2022

Background Prostate cancer (PCa) is the second most common neoplasm in male patients. To date, there's no certain indication about the maximum waiting time (WT) acceptable for treatment beginning and the impact on oncological and functional outcomes has not been well established. Methods Data from the National Research Council PCa monitoring multicenter project in Italy (Pros-IT CNR) were prospectively collected and analyzed. WT was defined as the time from the bioptical diagnosis of PCa to the first treatment received. Patients were divided in two groups, using a time frame of 90 days. Quality of life was measured through the Italian version of the University of California Los Angeles-Pros…

Genomic characterization of mosaic cutaneous pigmentary disorders

2019

Ntroduction: Mosaic cutaneous dyschromia is strongly evocative of an underlying genetic mosaicism. These post-zygotic events are challenging for conventional diagnostic tools. Thus, genetic basis of mosaic cutaneous dyschromia still remained poorly understood. Materials and Methods: The M.U.S.T.A.R.D. cohort gathers DNA from skin biopsies of patients with mosaic cutaneous dyschromia. After a specialised phenotype analysis, they are referred to either trio exome sequencing (ES) at 200X, or targeted ultra-deep sequencing (60,000X) of candidate genes. Data are analysed with a tailored pipeline, allowing detection of both low-rate nucleotidic variations or chromosomal events. Results: From 2013…

Anatomy of nerves of the lower extremities in the context of the treatment for varicose veins

2019

Injury of nerves of the lower extremity is the most prevalent complication associated with invasive treatment of varicose veins. These adverse events are particularly frequent after traditional surgical stripping and thermal ablative procedures. The most frequently injured nerves comprise the saphenous nerve, the sural nerve, and the anterior cutaneous branch of the femoral nerve. The high rate of injury to these nerves is primarily related to their close anatomical relationship with major trunks of the superficial venous system. The great saphenous vein is accompanied by two groups of sensory nerves. In its proximal part it runs along the anterior cutaneous branch of the femoral nerve. In …

Chronic Total Coronary Artery Occlusion Recanalisation with Percutaneous Coronary Intervention — Single Centre 10-Year Experience

2018

Abstract Coronary artery chronic total occlusions (CTO) are common — approximately one-third of patients with significant coronary artery disease on angiography have at least 1 CTO. Invasive treatment of these lesions still remain a major challenge for interventional cardiology due to their complexity. Historically, success rates have improved to about 60–70% by using only the traditional antegrade approach. The results have dramatically improved during the last decade after more widespread application of new retrograde techniques. The aim of our study was to review and analyse single hospital experience in CTO invasive treatment and to evaluate the long-term results. A total of 519 patient…

Cutaneous Leishmania infection: progress in pathogenesis research and experimental therapy.

2007

Studies in murine experimental Leishmania major infection have helped to understand the requirements for efficient development of T helper (Th)1/cytotoxic T (Tc)1-mediated protection against the parasite. As such they have revealed that Fc gamma receptor (Fc gamma R)I and Fc gamma RIII-mediated uptake of L. major amastigotes by dendritic cells (DC) is an important prerequisite for Th1 development. In addition, DC-derived cytokines contribute to adequate T-cell education. DC-based vaccines may thus provide an important tool for both the development of a prophylactic vaccine against leishmaniasis and - together with leishmanicidal drugs - for eliciting immune-deviating functions towards prote…

P2575Comparison of deep sedation with general anesthesia in patients undergoing percutaneous mitral valve repair (PMVR)

2018

Psychophysical response to electrocutaneous stimulation.

1984

A method is presented to determine a reliable stimulus-sensation relationship particularly suitable for electrocutaneous stimulation. An experimental intensity-discrimination curve was obtained through simple psychophysical comparison tasks, and sensory response was inferred from integration of a JND's density function. The psychophysical response resembles a power law, although departures cannot be described in terms of a unique exponent. An estimate of binary information capacity per electrode is also given as a feature of a stimulation procedure that preserves a low value of the size-intensity product.

Mucocutaneous Leishmaniasis Mimicking Squamous Cell Carcinoma

2019

Leishmaniasis is a parasitic infectious disease caused by protozoan species belonging to the [...]