Search results for "Cyclin"
showing 10 items of 1021 documents
R-Rescovitine (Seliciclib) inhibits DNA damage-induced Cyclin A1 up-regulation and hinders non-homologous end joining: a rationale for therapeutic co…
2011
Shigella sonnei biotype g carrying class 2 integrons in southern Italy: a retrospective typing study by pulsed field gel electrophoresis
2006
Abstract Background Emergence and global dissemination of multiresistant strains of enteric pathogens is a very concerning problem from both epidemiological and Public Health points of view. Shigella sonnei is the serogroup of Shigella most frequently responsible for sporadic and epidemic enteritis in developed countries. The dissemination is associated most often to human to human transmission, but foodborne episodes have also been described. In recent years the circulation of multiresistant strains of S. sonnei biotype g carrying a class 2 integron has been reported in many countries worldwide. In southern Italy a strain with similar properties has been responsible for a large community o…
Racing with superior and inferior team-members: an experimental test of effort changes in a cycling team sprint
2020
The study purpose was to investigate the effect of ability on effort within a sport-specific conjunctive task. The hypothesis was that, compared to working alone, inferior team members would increa...
Shifts in microbial diversity through land use intensity as drivers of carbon mineralization in soil
2015
10 pages; International audience; Land use practices alter the biomass and structure of soil microbial communities. However, the impact of land management intensity on soil microbial diversity (i.e. richness and evenness) and consequences for functioning is still poorly understood. Here, we addressed this question by coupling molecular characterization of microbial diversity with measurements of carbon (C) mineralization in soils obtained from three locations across Europe, each representing a gradient of land management intensity under different soil and environmental conditions. Bacterial and fungal diversity were characterized by high throughput sequencing of ribosomal genes. Carbon cycl…
Nano- to Global-Scale Uncertainties in Terrestrial Enhanced Weathering.
2022
Enhanced weathering (EW) is one of the most promising negative emissions technologies urgently needed to limit global warming to at least below 2 °C, a goal recently reaffirmed at the UN Global Climate Change conference (i.e., COP26). EW relies on the accelerated dissolution of crushed silicate rocks applied to soils and is considered a sustainable solution requiring limited technology. While EW has a high theoretical potential of sequestering CO2, research is still needed to provide accurate estimates of carbon (C) sequestration when applying different silicate materials across distinct climates and major soil types in combination with a variety of plants. Here we elaborate on fundamental …
Lightweight Alloys Recycling and Processing through Innovative Friction Based Direct Technologies
In the last decades, the use of lightweight alloys has been spreading in almost any industrial field thanks to the relevant weight reduction allowed by the use of such materials. On the other hand, aluminium alloys are characterized by high-energy demands primary production cycles that are responsible for a relevant share of the global CO2 emissions. In order to limit and reverse such phenomenon, putting in place strategies to keep the material in the circle over multiple life cycles is mandatory and the concepts of circular economy, closed loop society and industrial symbiosis are progressively gathering more and more pace. Nevertheless, metal scraps are often mainly composed of chips resu…
Progresses in multi-materials billet manufacturing out of metal scraps through friction stir consolidation
2023
Abstract. The evolution of Friction Stir Consolidation (FSC) from recycling towards upcycling technique proved to be one of the excellent solid-state methods for manufacturing functionally graded billets. Multi-material Functional Graded Materials (FGMs) represent a novel class of materials characterized by a gradual change in properties and functions which can be tailored to enhance components performance. Manufacturing techniques play a critical role in achieving the designed compositional and microstructural distribution. Specifically, FSC allows the manufacturing of FGM billets out of metallic chips; the mixing of different metallic chips offers mutually exclusive mechanical properties …
A statistical design of experiments for optimizing the MALDI-TOF-MS sample preparation of polymers. An application in the assessment of the thermo-me…
2011
[EN] The sample preparation procedure for MALDI-TOF MS of polymers is addressed in this study by the application of a statistical Design of Experiments (DoE). Industrial poly (ethylene terephthalate) (PET) was chosen as model polymer. Different experimental settings (levels) for matrixes, analyte/matrix proportions and concentrations of cationization agent were considered. The quality parameters used for the analysis were signal-to-noise ratio and resolution. A closer inspection of the statistical results provided the study not only with the best combination of factors for the MALDI sample preparation, but also with a better understanding of the influence of the different factors, individua…
Assessing the MALDI-TOF MS sample preparation procedure to analyze the influence of thermo-oxidative ageing and thermo-mechanical degradation on poly…
2011
[EN] Multiple processing by means of successive injection cycles was used to simulate the thermo-mechanical degradation effects on the oligomeric distribution of PLA under mechanical recycling. Likewise, an accelerated thermal ageing over PLA glass transition was performed in order to simulate its service life. MALDI-TOF MS was used for the analysis and the sample preparation procedure was assessed by means of a statistical Design of Experiments (DoE). The quality effects in use for the analysis were signal-to-noise ratio and Resolution. Different matrixes, analyte/matrix proportions and the use of NaTFA as cationization agent were considered. A deep inspection of the statistical results pr…
Thermal and pressure-induced spin crossover in a novel three-dimensional Hoffman-like clathrate complex
2011
The synthesis and crystal structure of the interpenetrated metal–organic framework material Fe(bpac)2[Ag(CN)2]2 (bpac = 4,4′-bis(pyridyl)acetylene) are reported along with the characterization of its spin crossover properties by variable temperature magnetometry and Mossbauer spectroscopy. The complex presents an incomplete stepped spin transition as a function of temperature that is modified upon successive thermal cycling. The pressure-induced transition has also been investigated by means of high pressure Raman spectroscopy using a diamond anvil cell. The results show that it is possible to reach the thermally-inaccessible fully low spin state at room temperature by applying hydrostatic …