Search results for "D region"

2020

Background Dental professionals are subjected to higher risks for musculoskeletal disorders (MSDs) than other professional groups, especially the hand region. This study aims to investigate the prevalence of hand complaints among dentists (Ds) and dental assistants (DAs) and examines applied therapies. Methods For this purpose, an online questionnaire analysed 389 Ds (240female/149male) and 406 DAs (401female/5male) working in Germany. The self-reported data of the two occupational groups were compared with regard to the topics examined. The questionnaire was based on the Nordic Questionnaire (self-reported lifetime, 12-month and 7-day MSDs prevalence of the hand, the conducted therapy and…

Sequences in the 5′ Nontranslated Region of Hepatitis C Virus Required for RNA Replication

2001

ABSTRACT Sequences in the 5′ and 3′ termini of plus-strand RNA viruses harbor cis -acting elements important for efficient translation and replication. In case of the hepatitis C virus (HCV), a plus-strand RNA virus of the family Flaviviridae , a 341-nucleotide-long nontranslated region (NTR) is located at the 5′ end of the genome. This sequence contains an internal ribosome entry site (IRES) that is located downstream of an about 40-nucleotide-long sequence of unknown function. By using our recently developed HCV replicon system, we mapped and characterized the sequences in the 5′ NTR required for RNA replication. We show that deletions introduced into the 5′ terminal 40 nucleotides abolis…

Mutations in hepatitis C virus RNAs conferring cell culture adaptation.

2001

ABSTRACT As an initial approach to studying the molecular replication mechanisms of hepatitis C virus (HCV), a major causative agent of acute and chronic liver disease, we have recently developed selectable self-replicating RNAs. These replicons lacked the region encoding the structural proteins and instead carried the gene encoding the neomycin phosphotransferase. Although the replication levels of these RNAs within selected cells were high, the number of G418-resistant colonies was reproducibly low. In a search for the reason, we performed a detailed analysis of replicating HCV RNAs and identified several adaptive mutations enhancing the efficiency of colony formation by several orders of…

Heterogeneous nuclear ribonucleoprotein (hnRNP) F is a novel component of oligodendroglial RNA transport granules contributing to regulation of myeli…

2011

Myelin basic protein (MBP) is a major component of central nervous system (CNS) myelin. The absence of MBP results in the loss of almost all compact myelin in the CNS. MBP mRNA is sorted into RNA granules that are transported to the periphery of oligodendrocytes in a translationally inactive state. A central mediator of this transport process is the trans-acting factor heterogeneous nuclear ribonucleoprotein (hnRNP) A2 that binds to the cis-acting A2-response element in the 3′UTR of MBP mRNA. Recently, we found that activation of the Src family nonreceptor tyrosine kinase Fyn in oligodendrocytes leads to phosphorylation of hnRNP A2 and to increased translation of MBP mRNA. Here, we identify…

Espacio urbano y política de vivienda en España durante los años ochenta

1996

Il perimetro variabile dell’insindacabilità dei Consiglieri regionali: la vis politica delle decisioni “strategiche” per l’economia regionale. Nota a…

2022

La sentenza n. 90 del 2022 della Corte costituzionale risolve un conflitto di attribuzioni fra Stato e Regione Valle d’Aosta originato dalla sentenza della sezione giurisdizionale III centrale della Corte dei conti (la nr. 350 del 2021) di condanna per responsabilità da danno erariale nei confronti di diversi Consiglieri della Regione per aver deliberato un atto amministrativo concernente un’operazione di rifinanziamento del Casinò di Saint-Vincent. A differenza dei criteri precedentemente seguiti per definire l’ambito di applicazione dell’insindacabilità dei Consiglieri regionali nell’ipotesi di deliberazioni consiliari relative ad atti non legislativi (cfr. spec. Corte cost. nn. 69 e 70 d…

Three (marginal?) questions regarding convergence

2004

This paper focuses on three (marginal?) questions surrounding the analysis of economic convergence and uses Spanish provinces as a means of illustration. The three questions in hand are the following: (i) given that the geographical units of analysis are usually quite different in economic size, is the weighting of economic units relevant in convergence analysis? (ii) the average per capita income of a given region, or country, is the first moment in the distribution of income, but what about the second moment, inequality? Have we converged in inequality? and (iii) an aggregate welfare index must take into account, at least, the evolution of the first two moments of the distribution of inco…

Total Factor Productivity Convergence Amongst Italian Regions: Some Evidence from Panel Unit Root Tests

2009

Byrne J. P., Fazio G. and Piacentino D. Total factor productivity convergence among Italian regions: some evidence from panel unit root tests. Regional Studies. This paper employs panel unit root tests to investigate convergence in total factor productivity (TFP) among Italian regions. These tests provide an inference valid in the presence of heterogeneity and cross-sectional dependence, and when the cross-sectional dimension is smaller than the time dimension, allowing the investigation of convergence among different subsets of regions. The results add a further dimension to the conventional view on growth dynamics in the Italian peninsula depicting a lack of regional TFP convergence not o…

Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications

2021

The highly infectious disease COVID-19 caused by the Betacoronavirus SARS-CoV-2 poses a severe threat to humanity and demands the redirection of scientific efforts and criteria to organized research projects. The international COVID19-NMR consortium seeks to provide such new approaches by gathering scientific expertise worldwide. In particular, making available viral proteins and RNAs will pave the way to understanding the SARS-CoV-2 molecular components in detail. The research in COVID19-NMR and the resources provided through the consortium are fully disclosed to accelerate access and exploitation. NMR investigations of the viral molecular components are designated to provide the essential…

Photosensitive Alternative Splicing of the Circadian Clock Gene timeless Is Population Specific in a Cold-Adapted Fly, Drosophila montana.

2018

To function properly, organisms must adjust their physiology, behavior and metabolism in response to a suite of varying environmental conditions. One of the central regulators of these changes is organisms' internal circadian clock, and recent evidence has suggested that the clock genes are also important in the regulation of seasonal adjustments. In particular, thermosensitive splicing of the core clock gene <i>timeless</i> in a cosmopolitan fly, <i>Drosophila melanogaster</i> , has implicated this gene to be involved in thermal adaptation. To further investigate this link we examined the splicing of <i>timeless</i> in a northern malt fly species, <i&…